Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio

2012 ◽  
Vol 13 (4) ◽  
pp. 982-991 ◽  
Author(s):  
Hong Zong ◽  
Thommey P. Thomas ◽  
Kyung-Hoon Lee ◽  
Ankur M. Desai ◽  
Ming-hsin Li ◽  
...  
Keyword(s):  
Folic Acid ◽  
Pamam Dendrimer ◽  
Dendrimer Conjugates

Synthesis of CpM(CO)3-DAB and -PAMAM Dendrimer Conjugates and Preliminary Evaluation of Their Biological Activity

2015 ◽  
Vol 2015 (9) ◽  
pp. 1505-1510 ◽  
Author(s):  
Wanning Hu ◽  
Jan Hoyer ◽  
Ines Neundorf ◽  
Preshendren Govender ◽  
Gregory S. Smith ◽  
...  
Keyword(s):  
Biological Activity ◽  
Pamam Dendrimer ◽  
Preliminary Evaluation ◽  
Dendrimer Conjugates

scholarly journals Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1422 ◽  
Author(s):  
Marcinkowska ◽  
Stanczyk ◽  
Janaszewska ◽  
Gajek ◽  
Ksiezak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Pamam Dendrimer ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Action ◽  
Her 2 ◽  
The Impact ◽  
Dendrimer Conjugates

Taxanes are considered fundamental drugs in the treatment of breast cancer, but despite the similarities, docetaxel (doc) and paclitaxel (ptx) work differently. For this reason, it is interesting to identify mechanisms of antitumor activity of PAMAM dendrimer conjugates that carry docetaxel or paclitaxel and monoclonal antibody trastuzumab, specifically targeted to cells which overexpressed HER-2. For this purpose, the impact on the level of reactive oxygen species, the mitochondrial membrane potential, cell cycle distribution and the activity of caspases-3/7, -8 and -9 of PAMAM-doc-trastuzumab and PAMAM-ptx-trastuzumab conjugates was determined and compared with free docetaxel and paclitaxel toward HER-2-positive (SKBR-3) and negative (MCF-7) human breast cancer cell lines. Moreover, apoptosis and necrosis were studied using flow cytometry and confocal microscopy, respectively. Our studies show the complexity of the potential mechanism of cytotoxic action of PAMAM-drug-trastuzumab conjugates that should be sought as a resultant of oxidative stress, mitochondrial activation of the caspase cascade and the HER-2 receptor blockade.

Adenoviral Vectors Coated with PAMAM Dendrimer Conjugates Allow CAR Independent Virus Uptake and Targeting to the EGF Receptor

2013 ◽  
Vol 10 (2) ◽  
pp. 606-618 ◽  
Author(s):  
Alexandra Vetter ◽  
Kulpreet S. Virdi ◽  
Sigrid Espenlaub ◽  
Wolfgang Rödl ◽  
Ernst Wagner ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Pamam Dendrimer ◽  
Adenoviral Vectors ◽  
Dendrimer Conjugates

scholarly journals Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA

Sensors ◽  
2009 ◽  
Vol 9 (8) ◽  
pp. 6346-6361 ◽  
Author(s):  
Hidetoshi Arima ◽  
Keiichi Motoyama
Keyword(s):  
Pamam Dendrimer ◽  
Dna And Rna ◽  
Dendrimer Conjugates

scholarly journals Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A3Adenosine Receptor and Coactivation of the P2Y14Receptor by a Tethered Nucleotide

2010 ◽  
Vol 21 (2) ◽  
pp. 372-384 ◽  
Author(s):  
Dilip K. Tosh ◽  
Lena S. Yoo ◽  
Moshe Chinn ◽  
Kunlun Hong ◽  
S. Michael Kilbey ◽  
...  
Keyword(s):  
Pamam Dendrimer ◽  
Dendrimer Conjugates

Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation

2016 ◽  
Vol 68 (8) ◽  
pp. 1010-1020 ◽  
Author(s):  
Burçin Yavuz ◽  
Sibel Bozdağ Pehlivan ◽  
Burcu Sümer Bolu ◽  
Rana Nomak Sanyal ◽  
İmran Vural ◽  
...  
Keyword(s):  
Pamam Dendrimer ◽  
In Vivo Evaluation ◽  
Dendrimer Conjugates

scholarly journals Improved Methodology for Monitoring Poly(amidoamine) Dendrimers Surface Transformations and Product Quality by Ultra Performance Liquid Chromatography

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Chevelle A. Cason ◽  
Stuart A. Oehrle ◽  
Thomas A. Fabré ◽  
Craig D. Girten ◽  
Keith A. Walters ◽  
...  
Keyword(s):  
Surface Modification ◽  
Liquid Chromatography ◽  
Product Quality ◽  
High Performance ◽  
Ultra Performance Liquid Chromatography ◽  
Pamam Dendrimer ◽  
Enhanced Sensitivity ◽  
First Time ◽  
Dendrimer Conjugates

Ultra performance liquid chromatography (UPLC) analysis was utilized for the first time as a methodology for monitoring poly(amidoamine) (PAMAM) dendrimer surface transformations and product quality. Results were compared to high-performance liquid chromatography (HPLC) and were found to provide a vastly improved analytical method for the characterization of dendrimer polydispersity and variance in a typical surface modification. The application of UPLC increased the average number of theoretical plates by a factor of 7 and reduced retention times of analytes by 36%, while improving the resolution capability to discriminate surface variances in dendrimers. The new UPLC procedures were used to monitor surface modification of [core: ethylenediamine]; (G = 4);dendri-poly(amidoamine)-(NH2)64(i.e., [EDA]; (G4);dendri-PAMAM-(NH2)64) to produce biotinylated dendrimer conjugates. The enhanced sensitivity and efficiency of the UPLC analyses allowed resolution of biotin substituent levels and a better characterization of the targeted dendrimer conjugates compared to traditional HPLC methodology.

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