Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation

2016 ◽  
Vol 68 (8) ◽  
pp. 1010-1020 ◽  
Author(s):  
Burçin Yavuz ◽  
Sibel Bozdağ Pehlivan ◽  
Burcu Sümer Bolu ◽  
Rana Nomak Sanyal ◽  
İmran Vural ◽  
...  
Keyword(s):  
Pamam Dendrimer ◽  
In Vivo Evaluation ◽  
Dendrimer Conjugates

scholarly journals Injectable PAMAM Dendrimer–PEG Hydrogels for the Treatment of Genital Infections: Formulation and in Vitro and in Vivo Evaluation

2011 ◽  
Vol 8 (4) ◽  
pp. 1209-1223 ◽  
Author(s):  
Raghavendra S. Navath ◽  
Anupa R. Menjoge ◽  
Hui Dai ◽  
Roberto Romero ◽  
Sujatha Kannan ◽  
...  
Keyword(s):  
Pamam Dendrimer ◽  
In Vivo Evaluation ◽  
Genital Infections ◽  
Peg Hydrogels

Polyamidoamine dendrimer and dextran conjugates: preparation, characterization, and in vitro and in vivo evaluation

2010 ◽  
Vol 64 (5) ◽  
Author(s):  
Prabhat Shrivastava ◽  
Royana Singh ◽  
Sushant Shrivastava
Keyword(s):  
Phosphate Buffer Solution ◽  
Pamam Dendrimer ◽  
Simulated Gastric Fluid ◽  
Ulcer Index ◽  
Buffer Solution ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Dextran 40

AbstractAmide and ester conjugates of aceclofenac with polyamidoamine (PAMAM-G0) dendrimer zero generation and dextran (40 kDa) polymeric carrier, respectively, are presented. The prepared conjugates were characterized by UV, TLC, HPLC, IR, and 1H NMR spectroscopy. The average degrees of substitution of amide and ester conjugates were determined and found to be (12.5 ± 0.24) % and (7.5 ± 0.25) %, respectively. The in vitro hydrolysis studies showed that dextran ester conjugate hydrolyzed faster in a phosphate buffer solution of pH 9.0 as compared to PAMAM dendrimer G0 amide conjugate, and followed the first order kinetics. No amount of the drug was regenerated at pH 1.2 in simulated gastric fluid. The dextran conjugate showed short half-life as compared to the PAMAM dendrimer conjugate. Anti-inflammatory and analgesic activities of the dendrimer conjugate were found to be similar to those of the standard drug. Results of chronic ulceroginic activity showed deep ulceration and high ulcer index for aceclofenac, whereas lower ulcer index was found for the PAMAM dendrimer and dextran (40 kDa) conjugates. Experimental data suggest that PAMAM dendrimer and dextran (40 kDa) can be used as carriers for the sustained delivery of aceclofenac along with a remarkable reduction in gastrointestinal toxicity.

In Vitro/In Vivo Evaluation of Dexamethasone—PAMAM Dendrimer Complexes for Retinal Drug Delivery

2015 ◽  
Vol 104 (11) ◽  
pp. 3814-3823 ◽  
Author(s):  
Burçin Yavuz ◽  
Sibel Bozdagğ Pehlivan ◽  
İmran Vural ◽  
Nurşen Ünlü
Keyword(s):  
Drug Delivery ◽  
Pamam Dendrimer ◽  
In Vivo Evaluation

Radiolabelling and in vivo evaluation of [11C]GSK215083 as potential PET radioligand for the 5-HT6 receptor in the porcine brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S598-S598 ◽  
Author(s):  
Laurent Martarello ◽  
Vincent J Cunningham ◽  
Julian C Matthews ◽  
Eugenii Rabiner ◽  
Steen Jakobsen ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porcine Brain

In vivo evaluation of [11C]CNS-5161 as a use-dependent ligand for the NMDA glutamate receptor channel

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S595-S595 ◽  
Author(s):  
Wynne K Schiffer ◽  
Deborah Pareto-Onghena ◽  
HaiTao Wu ◽  
Kuo-Shyan Lin ◽  
Andrew R Gibbs ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
In Vivo Evaluation ◽  
Nmda Glutamate Receptor ◽  
Receptor Channel

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory
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