Synthesis of CpM(CO)3-DAB and -PAMAM Dendrimer Conjugates and Preliminary Evaluation of Their Biological Activity

2015 ◽  
Vol 2015 (9) ◽  
pp. 1505-1510 ◽  
Author(s):  
Wanning Hu ◽  
Jan Hoyer ◽  
Ines Neundorf ◽  
Preshendren Govender ◽  
Gregory S. Smith ◽  
...  
Keyword(s):  
Biological Activity ◽  
Pamam Dendrimer ◽  
Preliminary Evaluation ◽  
Dendrimer Conjugates

scholarly journals Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1422 ◽  
Author(s):  
Marcinkowska ◽  
Stanczyk ◽  
Janaszewska ◽  
Gajek ◽  
Ksiezak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Pamam Dendrimer ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Action ◽  
Her 2 ◽  
The Impact ◽  
Dendrimer Conjugates

Taxanes are considered fundamental drugs in the treatment of breast cancer, but despite the similarities, docetaxel (doc) and paclitaxel (ptx) work differently. For this reason, it is interesting to identify mechanisms of antitumor activity of PAMAM dendrimer conjugates that carry docetaxel or paclitaxel and monoclonal antibody trastuzumab, specifically targeted to cells which overexpressed HER-2. For this purpose, the impact on the level of reactive oxygen species, the mitochondrial membrane potential, cell cycle distribution and the activity of caspases-3/7, -8 and -9 of PAMAM-doc-trastuzumab and PAMAM-ptx-trastuzumab conjugates was determined and compared with free docetaxel and paclitaxel toward HER-2-positive (SKBR-3) and negative (MCF-7) human breast cancer cell lines. Moreover, apoptosis and necrosis were studied using flow cytometry and confocal microscopy, respectively. Our studies show the complexity of the potential mechanism of cytotoxic action of PAMAM-drug-trastuzumab conjugates that should be sought as a resultant of oxidative stress, mitochondrial activation of the caspase cascade and the HER-2 receptor blockade.

Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio

2012 ◽  
Vol 13 (4) ◽  
pp. 982-991 ◽  
Author(s):  
Hong Zong ◽  
Thommey P. Thomas ◽  
Kyung-Hoon Lee ◽  
Ankur M. Desai ◽  
Ming-hsin Li ◽  
...  
Keyword(s):  
Folic Acid ◽  
Pamam Dendrimer ◽  
Dendrimer Conjugates

scholarly journals A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties

2016 ◽  
Vol 14 (46) ◽  
pp. 10787-10798 ◽  
Author(s):  
David Mangan ◽  
Neasa McNabola ◽  
Emily H. Clark ◽  
Isabel Bermudez ◽  
Susan Wonnacott ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Evaluation ◽  
New Synthesis

A new synthesis of mecamylamine allowed the preparation of analogues to probe biological activity.

Adenoviral Vectors Coated with PAMAM Dendrimer Conjugates Allow CAR Independent Virus Uptake and Targeting to the EGF Receptor

2013 ◽  
Vol 10 (2) ◽  
pp. 606-618 ◽  
Author(s):  
Alexandra Vetter ◽  
Kulpreet S. Virdi ◽  
Sigrid Espenlaub ◽  
Wolfgang Rödl ◽  
Ernst Wagner ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Pamam Dendrimer ◽  
Adenoviral Vectors ◽  
Dendrimer Conjugates

scholarly journals Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA

Sensors ◽  
2009 ◽  
Vol 9 (8) ◽  
pp. 6346-6361 ◽  
Author(s):  
Hidetoshi Arima ◽  
Keiichi Motoyama
Keyword(s):  
Pamam Dendrimer ◽  
Dna And Rna ◽  
Dendrimer Conjugates

scholarly journals Synthesis and Preliminary Evaluation of Biological Activity of Glycoconjugates Analogues of Acyclic Uridine Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2017 ◽  
Author(s):  
Roman Komor ◽  
Gabriela Pastuch-Gawolek ◽  
Ewelina Krol ◽  
Wieslaw Szeja
Keyword(s):  
Biological Activity ◽  
Bovine Milk ◽  
Nucleoside Analogues ◽  
Preliminary Evaluation ◽  
Synthetic Compounds ◽  
Enzyme Action ◽  
Enzyme Substrates ◽  
Donor Type ◽  
Natural Enzyme ◽  
Activity Of Enzymes

Herein we present the methodology for obtaining glycosyltransferase inhibitors, analogues of natural enzyme substrates of donor-type: UDP-glucose and UDP-galactose. The synthesis concerned glycoconjugates, nucleoside analogues containing an acyclic ribose mimetic linked to a uracil moiety in their structure. The biological activity of the synthesised compounds was determined on the basis of their ability to inhibit the model enzyme action of β-1,4-galactosyltransferase from bovine milk. The obtained results allowed to expand and supplement the existing library of synthetic compounds that are able to regulate the biological activity of enzymes from the GT class.

Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity

2016 ◽  
Vol 2016 (34) ◽  
pp. 5667-5677
Author(s):  
Koichi Narita ◽  
Yuya Katoh ◽  
Ken-ichi Ojima ◽  
Singo Dan ◽  
Takao Yamori ◽  
...  
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Preliminary Evaluation

scholarly journals Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A3Adenosine Receptor and Coactivation of the P2Y14Receptor by a Tethered Nucleotide

2010 ◽  
Vol 21 (2) ◽  
pp. 372-384 ◽  
Author(s):  
Dilip K. Tosh ◽  
Lena S. Yoo ◽  
Moshe Chinn ◽  
Kunlun Hong ◽  
S. Michael Kilbey ◽  
...  
Keyword(s):  
Pamam Dendrimer ◽  
Dendrimer Conjugates
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