scholarly journals Bone-Tissue-Engineering Material Poly(propylene fumarate):  Correlation between Molecular Weight, Chain Dimensions, and Physical Properties

2006 ◽  
Vol 7 (6) ◽  
pp. 1976-1982 ◽  
Author(s):  
Shanfeng Wang ◽  
Lichun Lu ◽  
Michael J. Yaszemski
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Physical Properties ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Material ◽  
Poly Propylene

In vitro degradation and bioactivity of poly(propylene fumarate)/bioactive glass sintered microsphere scaffolds for bone tissue engineering

2016 ◽  
Vol 23 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Sima Shahabi ◽  
Yashar Rezaei ◽  
Fathollah Moztarzadeh ◽  
Farhood Najafi
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
P Uptake ◽  
Surface Reactivity ◽  
Ion Concentration ◽  
Composite Scaffolds ◽  
Poly Propylene

AbstractWe developed degradable poly(propylene fumarate)/bioactive glass (PPF/BG) composite scaffolds based on a sintered microsphere technique and investigated the effects of BG content on the characteristics of these composite scaffolds. Immersion in a simulated body fluid (SBF) was used to evaluate the surface reactivity of composite scaffolds. The surface of composite scaffolds was covered with hydroxycarbonate apatite layer after 7 days of immersion. Ion concentration analyses revealed a decrease in P concentration and an increase in Si, Ca, and Sr concentrations in SBF immersed with composite scaffolds during the 3-week period. The Ca and P uptake rates decreased after 4 days of incubation. This coincided with the decrease of the Si release rate. These data lend support to the suggestion that the Si released from the BG content of scaffolds present in the polymer matrix was involved in the formation of the Ca-P layer. The evaluation of the in vitro degradation of composite microspheres revealed that the weight of scaffolds remained relatively constant during the first 3 weeks and then started to decrease slowly, losing 10.5% of their initial mass by week 12. Our results support the concept that these new bioactive, degradable composite scaffolds may be used for bone tissue engineering applications.

Nanoreinforcement of Poly(propylene fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering

2004 ◽  
Vol 5 (5) ◽  
pp. 1990-1998 ◽  
Author(s):  
R. Adam Horch ◽  
Naureen Shahid ◽  
Amit S. Mistry ◽  
Mark D. Timmer ◽  
Antonios G. Mikos ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Surface Modified ◽  
Poly Propylene

scholarly journals Physical Properties and Biocompatibility of a Core-Sheath Structure Composite Scaffold for Bone Tissue Engineering In Vitro

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Chuangjian Wang ◽  
Guolin Meng ◽  
Laquan Zhang ◽  
Zuo Xiong ◽  
Jian Liu
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Control Group ◽  
The Novel ◽  
Novel Scaffold ◽  
Sheath Structure

Scaffolds play a critical role in the practical realization of bone tissue engineering. The purpose of this study was to assess whether a core-sheath structure composite scaffold possesses admirable physical properties and biocompatibility in vitro. A novel scaffold composed of poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PLGA/β-TCP) skeleton wrapped with Type I collagen via low-temperature deposition manufacturing (LDM) was prepared, and bone mesenchymal stem cells (BMSCs) were used to evaluate cell behavior on the scaffold. PLGA/β-TCP skeleton was chosen as the control group. Physical properties were evaluated by pority ratio, compressive strength, and Young’s modulus. Scanning electron microscope (SEM) was used to study morphology of cells. Hydrophilicity was evaluated by water absorption ratio. Cell proliferation was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (MTT). Osteogenic differentiation of BMSCs was evaluated by alkaline phosphates activity (ALP). The results indicated that physical properties of the novel scaffold were as good as those of the control group, hydrophilicity was observably better (P<0.01) than that of control group, and abilities of proliferation and osteogenic differentiation of BMSCs on novel scaffold were significantly greater (P<0.05) than those of control group, which suggests that the novel scaffold possesses preferable characteristics and have high value in bone tissue engineering.

PEGylated boron nitride nanotube-reinforced poly(propylene fumarate) nanocomposite biomaterials

RSC Advances ◽  
2016 ◽  
Vol 6 (83) ◽  
pp. 79507-79519 ◽  
Author(s):  
Ana M. Díez-Pascual ◽  
Angel L. Díez-Vicente
Keyword(s):  
Tissue Engineering ◽  
Boron Nitride ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Boron Nitride Nanotube ◽  
Poly Propylene

Novel PPF/PEG-g-BNNTs nanocomposites were synthesized and characterized. These antibacterial and non-toxic biomaterials are suitable for bone tissue engineering.

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