Degradation and biocompatibility of a poly(propylene fumarate)-based/alumoxane nanocomposite for bone tissue engineering

2007 ◽  
Vol 83A (4) ◽  
pp. 940-953 ◽  
Author(s):  
A.S. Mistry ◽  
A.G. Mikos ◽  
J.A. Jansen
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Poly Propylene

In vitro degradation and bioactivity of poly(propylene fumarate)/bioactive glass sintered microsphere scaffolds for bone tissue engineering

2016 ◽  
Vol 23 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Sima Shahabi ◽  
Yashar Rezaei ◽  
Fathollah Moztarzadeh ◽  
Farhood Najafi
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
P Uptake ◽  
Surface Reactivity ◽  
Ion Concentration ◽  
Composite Scaffolds ◽  
Poly Propylene

AbstractWe developed degradable poly(propylene fumarate)/bioactive glass (PPF/BG) composite scaffolds based on a sintered microsphere technique and investigated the effects of BG content on the characteristics of these composite scaffolds. Immersion in a simulated body fluid (SBF) was used to evaluate the surface reactivity of composite scaffolds. The surface of composite scaffolds was covered with hydroxycarbonate apatite layer after 7 days of immersion. Ion concentration analyses revealed a decrease in P concentration and an increase in Si, Ca, and Sr concentrations in SBF immersed with composite scaffolds during the 3-week period. The Ca and P uptake rates decreased after 4 days of incubation. This coincided with the decrease of the Si release rate. These data lend support to the suggestion that the Si released from the BG content of scaffolds present in the polymer matrix was involved in the formation of the Ca-P layer. The evaluation of the in vitro degradation of composite microspheres revealed that the weight of scaffolds remained relatively constant during the first 3 weeks and then started to decrease slowly, losing 10.5% of their initial mass by week 12. Our results support the concept that these new bioactive, degradable composite scaffolds may be used for bone tissue engineering applications.

Nanoreinforcement of Poly(propylene fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering

2004 ◽  
Vol 5 (5) ◽  
pp. 1990-1998 ◽  
Author(s):  
R. Adam Horch ◽  
Naureen Shahid ◽  
Amit S. Mistry ◽  
Mark D. Timmer ◽  
Antonios G. Mikos ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Surface Modified ◽  
Poly Propylene

PEGylated boron nitride nanotube-reinforced poly(propylene fumarate) nanocomposite biomaterials

RSC Advances ◽  
2016 ◽  
Vol 6 (83) ◽  
pp. 79507-79519 ◽  
Author(s):  
Ana M. Díez-Pascual ◽  
Angel L. Díez-Vicente
Keyword(s):  
Tissue Engineering ◽  
Boron Nitride ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Boron Nitride Nanotube ◽  
Poly Propylene

Novel PPF/PEG-g-BNNTs nanocomposites were synthesized and characterized. These antibacterial and non-toxic biomaterials are suitable for bone tissue engineering.

scholarly journals Poly(propylene fumarate) reinforced dicalcium phosphate dihydrate cement composites for bone tissue engineering

2012 ◽  
Vol 100A (7) ◽  
pp. 1792-1802 ◽  
Author(s):  
Daniel L. Alge ◽  
Jeffrey Bennett ◽  
Trevor Treasure ◽  
Sherry Voytik-Harbin ◽  
W. Scott Goebel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Dicalcium Phosphate ◽  
Cement Composites ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Poly Propylene

Poly(propylene fumarate) Bone Tissue Engineering Scaffold Fabrication Using Stereolithography:  Effects of Resin Formulations and Laser Parameters

2007 ◽  
Vol 8 (4) ◽  
pp. 1077-1084 ◽  
Author(s):  
Kee-Won Lee ◽  
Shanfeng Wang ◽  
Bradley C. Fox ◽  
Erik L. Ritman ◽  
Michael J. Yaszemski ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffold ◽  
Scaffold Fabrication ◽  
Laser Parameters ◽  
Poly Propylene

Bone Tissue Engineering Incorporating Poly(Propylene Fumarate) Composites: A Mini Review

Nano LIFE ◽  
2016 ◽  
Vol 06 (03n04) ◽  
pp. 1642011 ◽  
Author(s):  
Emily G. Westbrook
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Chemical Properties ◽  
Living Cells ◽  
Physical And Chemical Properties ◽  
Significant Research ◽  
Poly Propylene ◽  
Physical And Chemical ◽  
And Chemical Properties

Tissue engineering is intended to manipulate living cells to help develop substitutes for native tissues or remodel tissue. Bioartificial tissues are commonly explored in various tissue engineering ventures to overcome the disadvantages of working with native tissue. Poly(propylene fumarate) is a potential biomaterial for bioartificial bone grafts. The polymer’s many desirable physical and chemical properties have drawn significant research interest. This miniature review is intended to cover a small portion of the investigations of poly(propylene fumarate) as a bone tissue engineering biomaterial.

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

PLGA+HA/βTCP scaffold incorporating simvastatin: a promising biomaterial for bone tissue engineering

2020 ◽  
Author(s):  
Mariane Beatriz Sordi ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Águedo Aragones ◽  
Mabel Mariela Rodríguez Cordeiro ◽  
Ricardo de Souza Magini
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Thermal Analyses ◽  
Chemical Properties ◽  
Biological Properties ◽  
Scanning Calorimetry ◽  
Evaporation Technique ◽  
Porosity Analysis ◽  
Biphasic Ceramic

The aim of this study was to synthesize, characterize, and evaluate degradation and biocompatibility of poly(lactic-co-glycolic acid) + hydroxyapatite / β-tricalcium phosphate (PLGA+HA/βTCP) scaffolds incorporating simvastatin (SIM) to verify if this biomaterial might be promising for bone tissue engineering. Samples were obtained by the solvent evaporation technique. Biphasic ceramic particles (70% HA, 30% βTCP) were added to PLGA in a ratio of 1:1. Samples with SIM received 1% (m:m) of this medication. Scaffolds were synthesized in a cylindric-shape and sterilized by ethylene oxide. For degradation analysis, samples were immersed in PBS at 37 °C under constant stirring for 7, 14, 21, and 28 days. Non-degraded samples were taken as reference. Mass variation, scanning electron microscopy, porosity analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry were performed to evaluate physico-chemical properties. Wettability and cytotoxicity tests were conducted to evaluate the biocompatibility. Microscopic images revealed the presence of macro, meso, and micropores in the polymer structure with HA/βTCP particles homogeneously dispersed. Chemical and thermal analyses presented very similar results for both PLGA+HA/βTCP and PLGA+HA/βTCP+SIM. The incorporation of simvastatin improved the hydrophilicity of scaffolds. Additionally, PLGA+HA/βTCP and PLGA+HA/βTCP+SIM scaffolds were biocompatible for osteoblasts and mesenchymal stem cells. In summary, PLGA+HA/βTCP scaffolds incorporating simvastatin presented adequate structural, chemical, thermal, and biological properties for bone tissue engineering.

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