Nanoreinforcement of Poly(propylene fumarate)-Based Networks with Surface Modified Alumoxane Nanoparticles for Bone Tissue Engineering

2004 ◽  
Vol 5 (5) ◽  
pp. 1990-1998 ◽  
Author(s):  
R. Adam Horch ◽  
Naureen Shahid ◽  
Amit S. Mistry ◽  
Mark D. Timmer ◽  
Antonios G. Mikos ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Surface Modified ◽  
Poly Propylene

scholarly journals THREE-DIMENSIONAL NANOCOMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING: FROM DESIGN TO APPLICATION

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250005 ◽  
Author(s):  
BIN DUAN ◽  
MIN WANG ◽  
WILLIAM W. LU
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Rabbit Model ◽  
Bone Morphogenetic Protein 2 ◽  
Human Umbilical Cord ◽  
Porous Structures ◽  
Tissue Engineering Scaffolds ◽  
Surface Modified ◽  
Nanocomposite Scaffolds

Selective laser sintering (SLS), a rapid prototyping technology, was investigated for producing bone tissue engineering scaffolds. Completely biodegradable osteoconductive calcium phosphate (Ca-P)/poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) scaffolds were successfully fabricated via SLS using Ca-P/PHBV nanocomposite microspheres. In the SLS manufacturing route, the architecture of tissue engineering scaffolds (pore shape, size, interconnectivity, etc.) can be designed and the sintering process can be optimized for obtaining scaffolds with desirable porous structures and mechanical properties. SLS was also shown to be very effective in producing highly complex porous structures using nanocomposite microspheres. To render SLS-formed Ca-P/PHBV scaffolds osteoinductive, recombinant human bone morphogenetic protein-2 (rhBMP-2) could be loaded onto the scaffolds. For achieving a controlled release of rhBMP-2 from scaffolds, surface modification of Ca-P/PHBV scaffolds by gelatin entrapment and heparin immobilization was needed. The immobilized heparin provided binding affinity for rhBMP-2. Surface modified Ca-P/PHBV nanocomposite scaffolds loaded with rhBMP-2 enhanced the proliferation of human umbilical cord derived mesenchymal stem cells (hUCMSCs) and also their alkaline phosphatase activity. In in vivo experiments using a rabbit model, surface modified Ca-P/PHBV nanocomposite scaffolds loaded with rhBMP-2 promoted ectopic bone formation, exhibiting their osteoinductivity. The strategy of combining advanced scaffold fabrication, nanocomposite material, and controlled growth factor delivery is promising for bone tissue regeneration.

scholarly journals Mesoporous Silica Based Nanostructures for Bone Tissue Regeneration

2021 ◽  
Vol 8 ◽  
Author(s):  
Sougata Ghosh ◽  
Thomas J. Webster
Keyword(s):  
Tissue Engineering ◽  
Mesoporous Silica ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Mesoporous Silica Nanoparticles ◽  
Fluorescein Isothiocyanate ◽  
Bone Tissue Regeneration ◽  
Surface Modified ◽  
Remarkable Progress

Porous nano-scaffolds provide for better opportunities to restore, maintain, and improve functions of damaged tissues and organs by facilitating tissue regeneration. Various nanohybrids composed of mesoporous silica nanoparticles (MSNs) are being widely explored for tissue engineering. Since biological activity is enhanced by several orders of magnitude in multicomponent scaffolds, remarkable progress has been observed in this field, which has aimed to develop the controlled synthesis of multifunctional MSNs with tuneable pore size, efficient delivering capacity of bioactive factors, as well as enhanced biocompatibility and biodegradability. In this review, we aim to provide a broad survey of the synthesis of multifunctional MSN based nanostructures with exotic shapes and sizes. Further, their promise as a novel nanomedicine is also elaborated with respect to their role in bone tissue engineering. Also, recent progress in surface modification and functionalization with various polymers like poly (l-lactic acid)/poly (ε-caprolactone), polylysine-modified polyethylenimine, poly (lactic-co-glycolic acid), and poly (citrate-siloxane) and biological polymers like alginate, chitosan, and gelatine are also covered. Several attempts for conjugating drugs like dexamethasone and β–estradiol, antibiotics like vancomycin and levofloxaci, and imaging agents like fluorescein isothiocyanate and gadolinium, on the surface modified MSNs are also covered. Finally, the scope of developing orthopaedic implants and potential trends in 3D bioprinting applications of MSNs are also discussed. Hence, MSNs based nanomaterials may serve as improved candidate biotemplates or scaffolds for numerous bone tissue engineering, drug delivery and imaging applications deserving our full attention now.

In vitro degradation and bioactivity of poly(propylene fumarate)/bioactive glass sintered microsphere scaffolds for bone tissue engineering

2016 ◽  
Vol 23 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Sima Shahabi ◽  
Yashar Rezaei ◽  
Fathollah Moztarzadeh ◽  
Farhood Najafi
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
P Uptake ◽  
Surface Reactivity ◽  
Ion Concentration ◽  
Composite Scaffolds ◽  
Poly Propylene

AbstractWe developed degradable poly(propylene fumarate)/bioactive glass (PPF/BG) composite scaffolds based on a sintered microsphere technique and investigated the effects of BG content on the characteristics of these composite scaffolds. Immersion in a simulated body fluid (SBF) was used to evaluate the surface reactivity of composite scaffolds. The surface of composite scaffolds was covered with hydroxycarbonate apatite layer after 7 days of immersion. Ion concentration analyses revealed a decrease in P concentration and an increase in Si, Ca, and Sr concentrations in SBF immersed with composite scaffolds during the 3-week period. The Ca and P uptake rates decreased after 4 days of incubation. This coincided with the decrease of the Si release rate. These data lend support to the suggestion that the Si released from the BG content of scaffolds present in the polymer matrix was involved in the formation of the Ca-P layer. The evaluation of the in vitro degradation of composite microspheres revealed that the weight of scaffolds remained relatively constant during the first 3 weeks and then started to decrease slowly, losing 10.5% of their initial mass by week 12. Our results support the concept that these new bioactive, degradable composite scaffolds may be used for bone tissue engineering applications.

PEGylated boron nitride nanotube-reinforced poly(propylene fumarate) nanocomposite biomaterials

RSC Advances ◽  
2016 ◽  
Vol 6 (83) ◽  
pp. 79507-79519 ◽  
Author(s):  
Ana M. Díez-Pascual ◽  
Angel L. Díez-Vicente
Keyword(s):  
Tissue Engineering ◽  
Boron Nitride ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Boron Nitride Nanotube ◽  
Poly Propylene

Novel PPF/PEG-g-BNNTs nanocomposites were synthesized and characterized. These antibacterial and non-toxic biomaterials are suitable for bone tissue engineering.

scholarly journals Poly(propylene fumarate) reinforced dicalcium phosphate dihydrate cement composites for bone tissue engineering

2012 ◽  
Vol 100A (7) ◽  
pp. 1792-1802 ◽  
Author(s):  
Daniel L. Alge ◽  
Jeffrey Bennett ◽  
Trevor Treasure ◽  
Sherry Voytik-Harbin ◽  
W. Scott Goebel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Dicalcium Phosphate ◽  
Cement Composites ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Poly Propylene

Poly(propylene fumarate) Bone Tissue Engineering Scaffold Fabrication Using Stereolithography:  Effects of Resin Formulations and Laser Parameters

2007 ◽  
Vol 8 (4) ◽  
pp. 1077-1084 ◽  
Author(s):  
Kee-Won Lee ◽  
Shanfeng Wang ◽  
Bradley C. Fox ◽  
Erik L. Ritman ◽  
Michael J. Yaszemski ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffold ◽  
Scaffold Fabrication ◽  
Laser Parameters ◽  
Poly Propylene

scholarly journals Surface-modified 3D starch-based scaffold for improved endothelialization for bone tissue engineering

2009 ◽  
Vol 19 (24) ◽  
pp. 4091 ◽  
Author(s):  
M. I. Santos ◽  
I. Pashkuleva ◽  
C. M. Alves ◽  
M. E. Gomes ◽  
S. Fuchs ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Surface Modified
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