Hydrolytic and Enzymatic Degradation of Nanoparticles Based on Amphiphilic Poly(γ-glutamic acid)-graft-l-Phenylalanine Copolymers

2006 ◽  
Vol 7 (1) ◽  
pp. 297-303 ◽  
Author(s):  
Takami Akagi ◽  
Mariko Higashi ◽  
Tatsuo Kaneko ◽  
Toshiyuki Kida ◽  
Mitsuru Akashi
Keyword(s):  
Glutamic Acid ◽  
Enzymatic Degradation

Enzymatic degradation of synthetic poly(.ALPHA.-amino acid) fibers. [1]. Poly(L-glutamic acid) fiber.

1987 ◽  
Vol 43 (9) ◽  
pp. 462-470 ◽  
Author(s):  
Toshio Hayashi ◽  
Juzo Takahashi ◽  
Akio Nakajima
Keyword(s):  
Amino Acid ◽  
Glutamic Acid ◽  
Enzymatic Degradation ◽  
Alpha Amino Acid

Nachweis und Bestimmung eines Hyaluronat-Protein-Komplexes in der Peritonealflüssigkeit von Ratten nach Injektion von Phytohämagglutinin / Occurence and Estimation of a Hyaluronate Protein Complex in the Peritoneal Fluid of Rats after Injection of Phytohemagglutinin

1972 ◽  
Vol 27 (4) ◽  
pp. 414-419 ◽  
Author(s):  
H. Greiling ◽  
W. Mohr ◽  
G. Beneke
Keyword(s):  
Amino Acids ◽  
Glutamic Acid ◽  
Aspartic Acid ◽  
Protein Complex ◽  
Intraperitoneal Injection ◽  
Peritoneal Fluid ◽  
Enzymatic Degradation ◽  
Cetylpyridinium Chloride ◽  
Maximum Amount

In the peritoneal fluid of rats hyaluronate is produced after intraperitoneal injection of phytohemagglutinin.The hyaluronate concentration was quantitated spectrophotometrically after enzymatic degradation by hyaluronatlyase and a maximum amount of 90 mg% hyaluronate was found after intraperitoneal injection. The production of hyaluronate after phytohemagglutinin injection is dependent on the time and concentration of the phytohemagglutinin. Maximum hyaluronate synthesis is about 48 h after phytohemagglutinin, after this time the hyaluronate concentration is decreased.After phytohemagglutinin stimulation we isolated a hyaluronate protein complex from the peritoneal fluid by cetylpyridinium chloride precipitation followed by chromatography on Biogel P-150. The dominating amino acids were aspartic acid and glutamic acid.

In vitro Enzymatic Degradation of Nanoparticles Prepared from Hydrophobically-Modified Poly(γ-glutamic acid)

2005 ◽  
Vol 5 (7) ◽  
pp. 598-602 ◽  
Author(s):  
Takami Akagi ◽  
Mariko Higashi ◽  
Tatsuo Kaneko ◽  
Toshiyuki Kida ◽  
Mitsuru Akashi
Keyword(s):  
Glutamic Acid ◽  
Enzymatic Degradation ◽  
Hydrophobically Modified

Role of the exosporial membrane in attachment and germination of C. sporogenes

1993 ◽  
Vol 51 ◽  
pp. 38-39
Author(s):  
B.J. Panessa-Warren ◽  
G.T. Tortora ◽  
J.B. Warren
Keyword(s):  
Enzymatic Degradation ◽  
Light Transmission ◽  
Extended Period ◽  
Growth Conditions ◽  
Clostridium Sporogenes ◽  
Radiation Chemical ◽  
Physical Trauma ◽  
Extended Contact ◽  
Cold Pressure

Some bacteria are capable of forming highly resistant spores when environmental conditions are not adequate for growth. Depending on the genus and species of the bacterium, these endospores are resistant in varying degrees to heat, cold, pressure, enzymatic degradation, ionizing radiation, chemical sterilants,physical trauma and organic solvents. The genus Clostridium, responsible for botulism poisoning, tetanus, gas gangrene and diarrhea in man, produces endospores which are highly resistant. Although some sporocides can kill Clostridial spores, the spores require extended contact with a sporocidal agent to achieve spore death. In most clinical situations, this extended period of treatment is not possible nor practical. This investigation examines Clostridium sporogenes endospores by light, transmission and scanning electron microscopy under various dormant and growth conditions, cataloging each stage in the germination and outgrowth process, and analyzing the role played by the exosporial membrane in the attachment and germination of the spore.

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