Modeling Duplex DNA Oligonucleotides with Modified Pyrimidine Bases

1997 ◽  
pp. 312-328
Author(s):  
John Miller ◽  
Michael Cooney ◽  
Karol Miaskiewicz ◽  
Roman Osman
Keyword(s):  
Duplex Dna ◽  
Dna Oligonucleotides ◽  
Pyrimidine Bases

Mechanism for Radical Cation Transport in Duplex DNA Oligonucleotides

2004 ◽  
Vol 126 (9) ◽  
pp. 2877-2884 ◽  
Author(s):  
Chu-Sheng Liu ◽  
Rigoberto Hernandez ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Cation Transport ◽  
Duplex Dna ◽  
Dna Oligonucleotides

Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip

Lab on a Chip ◽  
2012 ◽  
Vol 12 (24) ◽  
pp. 5160 ◽  
Author(s):  
Namhyun Choi ◽  
Kangsun Lee ◽  
Dong Woo Lim ◽  
Eun Kyu Lee ◽  
Soo-Ik Chang ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Duplex Dna ◽  
Dna Oligonucleotides

Effect of Netropsin on One-electron Oxidation of Duplex DNA¶†

2004 ◽  
Vol 80 (3) ◽  
pp. 456 ◽  
Author(s):  
Lezah W. Roberts ◽  
Gary B. Schuster
Keyword(s):  
Duplex Dna

Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination

2020 ◽  
Author(s):  
Bapurao Bhoge ◽  
Ishu Saraogi
Keyword(s):  
Organic Chemistry ◽  
Chemical Biology ◽  
Reductive Amination ◽  
The Other ◽  
Dna Oligomers ◽  
Site Specific ◽  
Wide Applicability ◽  
Dna Oligonucleotides ◽  
Selective Functionalization

Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N<sup>2</sup>-amine of guanine/2’-deoxyguanine monophosphate. This method specifically modifies guanine in several tested DNA oligonucleotides, while leaving the other bases unaffected. Using this approach, we have successfully incorporated desired handles chemoselectively into DNA oligomers.

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