Mechanism for Radical Cation Transport in Duplex DNA Oligonucleotides

2004 ◽  
Vol 126 (9) ◽  
pp. 2877-2884 ◽  
Author(s):  
Chu-Sheng Liu ◽  
Rigoberto Hernandez ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Cation Transport ◽  
Duplex Dna ◽  
Dna Oligonucleotides

Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

2011 ◽  
Vol 89 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Dna Analysis ◽  
Duplex Dna ◽  
Charge Migration ◽  
Electron Hole ◽  
Dna Oligomers ◽  
Phosphodiester Backbone ◽  
Cation Migration ◽  
Covalently Linked ◽  
Positively Charged

A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.

Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip

Lab on a Chip ◽  
2012 ◽  
Vol 12 (24) ◽  
pp. 5160 ◽  
Author(s):  
Namhyun Choi ◽  
Kangsun Lee ◽  
Dong Woo Lim ◽  
Eun Kyu Lee ◽  
Soo-Ik Chang ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Duplex Dna ◽  
Dna Oligonucleotides
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