Preparation and Characterization of Enzyme-Digestible Hydrogels from Natural Polymers by Gamma Irradiation

As public attention on sustainability is increasing, the use of polysaccharides as rheological modifiers in skin-care products is becoming the first choice. Polysaccharide associations can be used to increase the spreading properties of products and to optimize their sensorial profile. Since the choice of natural raw materials for cosmetics is wide, instrumental methodologies are useful for formulators to easily characterize the materials and to create mixtures with specific applicative properties. In this work, we performed rheological and texture analyses on samples formulated with binary and ternary associations of polysaccharides to investigate their structural and mechanical features as a function of the concentration ratios. The rheological measurements were conducted under continuous and oscillatory flow conditions using a rotational rheometer. An immersion/de-immersion test conducted with a texture analyzer allowed us to measure some textural parameters. Sclerotium gum and iota-carrageenan imparted high viscosity, elasticity, and firmness in the system; carob gum and pectin influenced the viscoelastic properties and determined high adhesiveness and cohesiveness. The results indicated that these natural polymers combined in appropriate ratios can provide a wide range of different textures and that the use of these two complementary techniques represents a valid pre-screening tool for the formulation of green products.

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Synthesis and characterization of hydrogels based on gamma irradiation of acrylic acid and methacrylic acid

Polymer Composites ◽

10.1002/pc.20588 ◽

2009 ◽

Vol 30 (5) ◽

pp. 569-575 ◽

Cited By ~ 10

Author(s):

Horia M. Nizam El-Din ◽

El-Sayed A. Hegazy ◽

Doaa M. Ibraheim

Keyword(s):

Acrylic Acid ◽

Gamma Irradiation ◽

Methacrylic Acid ◽

Synthesis And Characterization

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Design and Biophysical Characterization of Poly (l-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite

Polymers ◽

10.3390/polym10101061 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1061 ◽

Cited By ~ 10

Author(s):

Liying Li ◽

Kedong Song ◽

Yongzhi Chen ◽

Yiwei Wang ◽

Fangxin Shi ◽

...

Keyword(s):

Tissue Engineering ◽

Cell Culture ◽

Lactic Acid ◽

Average Diameter ◽

Natural Polymers ◽

Promoting Effect ◽

Biophysical Characterization ◽

Promising Tool ◽

Cell Carrier

Nowadays, microcarriers are widely utilized in drug delivery, defect filling, and cell culture. Also, many researchers focus on the combination of synthetic and natural polymers and bioactive ceramics to prepare composite biomaterials for tissue engineering and regeneration. In this study, three kinds of microcarriers were prepared based on physical doping and surface modification, named Poly (l-lactic) acid (PLLA), PLLA/nanohydroxyapatite (PLLA/nHA), and PLLA/nHA/Chitosan (PLLA/nHA/Ch). The physicochemical properties of the microcarriers and their functional performances in MC3T3-E1 cell culture were compared. Statistical results showed that the average diameter of PLLA microcarriers was 291.9 ± 30.7 μm, and that of PLLA/nHA and PLLA/nHA/Ch microcarriers decreased to 275.7 ± 30.6 μm and 269.4 ± 26.3 μm, respectively. The surface roughness and protein adsorption of microcarriers were enhanced with the doping of nHA and coating of chitosan. The cell-carrier cultivation stated that the PLLA/nHA microcarriers had the greatest proliferation-promoting effect, while the PLLA/nHA/Ch microcarriers performed the strongest attachment with MC3T3-E1 cells. Besides, the cells on the PLLA/nHA/Ch microcarriers exhibited optimal osteogenic expression. Generally, chitosan was found to improve microcarriers with superior characteristics in cell adhesion and differentiation, and nanohydroxyapatite was beneficial for microcarriers regarding sphericity and cell proliferation. Overall, the modified microcarriers may be considered as a promising tool for bone tissue engineering.

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Development and Characterization of Biocompatible Membranes from Natural Chitosan and Gelatin for Pervaporative Separation of Water–Isopropanol Mixture

Polymers ◽

10.3390/polym13172868 ◽

2021 ◽

Vol 13 (17) ◽

pp. 2868

Author(s):

Akshay S. Kulkarni ◽

Ashok M. Sajjan ◽

T. M. Yunus Khan ◽

Irfan Anjum Badruddin ◽

Sarfaraz Kamangar ◽

...

Keyword(s):

Surface Characteristics ◽

Permeation Flux ◽

X Ray Diffraction ◽

Natural Polymers ◽

X Ray ◽

Efficient Separation ◽

Differential Scanning Colorimetry ◽

Index Value ◽

Pervaporation Separation

Natural polymers have attracted a lot of interest in researchers of late as they are environmentally friendly, biocompatible, and possess excellent characters. Membranes forming natural polymers have provided a whole new dimension to the separation technology. In this work, chitosan-gelatin blend membranes were fabricated using chitosan as the base and varying the amount of gelatin. Transport, mechanical, and surface characteristics of the fabricated membranes were examined in detail by means of the characterizing techniques such as Fourier transform infrared spectroscopy, differential scanning colorimetry, wide angle X-ray diffraction, scanning electron microscope, and thermogravimetric analysis. In order to analyze the water affinity of the developed blend chitosan-gelatin membranes, the percentage degree of swelling was examined. Out of the fabricated membranes, the membrane loaded with 15 mass% of gelatin exhibited the better pervaporation performance with a pervaporation separation index value of 266 at 30 °C for the solution containing 10% in terms of the mass of water, which is the highest among the contemporary membranes. All the fabricated membranes were stable during the pervaporation experiments, and permeation flux of water for the fabricated membranes was dominant in the overall total permeation flux, signifying that the developed membranes could be chosen for efficient separation of water–isopropanol mixture on a larger scale.

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Antibacterial Properties of Biofilm Schiff Base Derived from Dialdehyde Cellulose and Chitosan

Indonesian Journal of Chemistry ◽

10.22146/ijc.34721 ◽

2019 ◽

Vol 19 (2) ◽

pp. 405

Author(s):

Agung Pratama ◽

Firman Sebayang ◽

Rumondang Bulan Nasution

Keyword(s):

Tensile Strength ◽

Antibacterial Activity ◽

Schiff Base ◽

Antibacterial Properties ◽

Oxidized Cellulose ◽

Natural Polymers ◽

Dialdehyde Cellulose ◽

Ft Ir ◽

Ir Analysis

Cellulose and chitosan are natural polymers that have been used as biocomposite. The aim of this research is to obtain biofilms from chitosan and oxidized cellulose crosslinks. This research is divided into three steps, i.e., isolation of cellulose from oil palm trunk and oxidation of cellulose using NaIO4 (0.2; 0.4; 0.6; 0.8; 1.0 mg/mL) to obtain dialdehyde cellulose (DAC), crosslink of oxidized cellulose with chitosan (DD = 72.85%) to obtain biofilm of chitosan/DAC (CDAC), and characterization of biofilms. The crosslinked reaction was confirmed by FT-IR analysis that showed the spectrum of Schiff base C=N group at 1651 cm–1. Tensile strength increased gradually when the NaIO4 concentration used was 0.2–0.6 mg/mL, but after those concentrations, the tensile strength slightly decreased. The morphology analysis showed that CDAC had smoother morphology than DAC, which was shown rough and showed some particle indicated the presence of unreacted cellulose. CDAC biofilms that prepared with 1.0 mg/mL NaIO4 showed the greatest antibacterial activity.

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Modification of PLA-Based Films by Grafting or Coating

Journal of Functional Biomaterials ◽

10.3390/jfb11020030 ◽

2020 ◽

Vol 11 (2) ◽

pp. 30 ◽

Cited By ~ 1

Author(s):

Aleksandra Miletić ◽

Ivan Ristić ◽

Maria-Beatrice Coltelli ◽

Branka Pilić

Keyword(s):

Surface Modification ◽

Active Component ◽

Mechanical Characterization ◽

Natural Polymer ◽

Natural Polymers ◽

Hydrophilic Surfaces ◽

Nanostructured Systems ◽

Grafting From ◽

Specific Challenge

Recently, the demand for the use of natural polymers in the cosmetic, biomedical, and sanitary sectors has been increasing. In order to meet specific functional properties of the products, usually, the incorporation of the active component is required. One of the main problems is enabling compatibility between hydrophobic and hydrophilic surfaces. Therefore, surface modification is necessary. Poly(lactide) (PLA) is a natural polymer that has attracted a lot ofattention in recent years. It is bio-based, can be produced from carbohydrate sources like corn, and it is biodegradable. The main goal of this work was the functionalization of PLA, inserting antiseptic and anti-inflammatory nanostructured systems based on chitin nanofibrils–nanolignin complexes ready to be used in the biomedical, cosmetics, and sanitary sectors. The specific challenge of this investigation was to increase the interaction between the hydrophobic PLA matrix with hydrophilic chitin–lignin nanoparticle complexes. First, chemical modification via the “grafting from” method using lactide oligomers was performed. Then, active coatings with modified and unmodified chitin–lignin nanoparticle complexes were prepared and applied on extruded PLA-based sheets. The chemical, thermal, and mechanical characterization of prepared samples was carried out and the obtained results were discussed.

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