scholarly journals The Stability of Myocilin Olfactomedin Domain Variants Provides New Insight into Glaucoma as a Protein Misfolding Disorder

Biochemistry ◽  
2011 ◽  
Vol 50 (26) ◽  
pp. 5824-5833 ◽  
Author(s):  
J. Nicole Burns ◽  
Katherine C. Turnage ◽  
Chandler A. Walker ◽  
Raquel L. Lieberman
Keyword(s):  
Protein Misfolding ◽  
Protein Misfolding Disorder ◽  
The Stability ◽  
Insight Into

scholarly journals Bioinspired organometallic chemistry

2002 ◽  
Vol 74 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Lanny S. Liebeskind ◽  
Jiri Srogl ◽  
Cecile Savarin ◽  
Concepcion Polanco
Keyword(s):  
Organometallic Chemistry ◽  
Refractory Metal ◽  
Redox Active ◽  
The Stability ◽  
New Procedures ◽  
Sulfur Containing ◽  
Insight Into

Given the stability of the bond between a mercaptide ligand and various redox-active metals, it is of interest that Nature has evolved significant metalloenzymatic processes that involve key interactions of sulfur-containing functionalities with metals such as Ni, Co, Cu, and Fe. From a chemical perspective, it is striking that these metals can function as robust biocatalysts in vivo, even though they are often "poisoned" as catalysts in vitro through formation of refractory metal thiolates. Insight into the nature of this chemical discrepancy is under study in order to open new procedures in synthetic organic and organometallic chemistry.

scholarly journals On the Trigonometric Descriptions of Colors

2016 ◽  
Vol 8 (3) ◽  
pp. 5
Author(s):  
Jirí Stavek
Keyword(s):  
Experimental Data ◽  
Transverse Energy ◽  
Gravitational Constant ◽  
Isaac Newton ◽  
Type Ia ◽  
New Interpretation ◽  
The Stability ◽  
Mass Evaporation ◽  
Supernovae Type Ia ◽  
Insight Into

<p class="1Body">An attempt is presented for the description of the spectral colors using the standard trigonometric tools in order to extract more information about photons. We have arranged the spectral colors on an arc of the circle with the radius R = 1 and the central angle θ = π/3 when we have defined cos (θ) = λ<sub>380</sub>/λ<sub>760</sub> = 0.5. Several trigonometric operations were applied in order to find the gravity centers for the scotopic, photopic, and mesopic visions. The concept of the center of gravity of colors introduced Isaac Newton. We have postulated properties of the long-lived photons with the new interpretation of the Hubble (Zwicky-Nernst) constant H<sub>0</sub> = 2.748… * 10<sup>-18</sup> kg kg<sup>-1 </sup>s<sup>-1</sup>, the specific mass evaporation rate (SMER) of gravitons from the source mass. The stability of international prototypes of kilogram has been regularly checked. We predict that those standard kilograms due to the evaporation of gravitons lost 8.67 μg kg<sup>-1</sup> century<sup>-1</sup>. The energy of long-lived photons was trigonometrically decomposed into three parts that could be experimentally tested: longitudinal energy, transverse energy and energy of evaporated gravitons. We tested the properties of the long-lived photons with the experimental data published for the best available standard candles: supernovae Type Ia. There was found a surprising match of those experimental data with the model of the long-lived photons. Finally, we have proposed a possible decomposition of the big G (Newtonian gravitational constant) and the small kappa κ (Einsteinian gravitational constant) in order to get a new insight into the mysterious gravitational force and/or the curvature concept.</p>

scholarly journals Influence of additives on suspension structure

2021 ◽  
Vol 10 (1) ◽  
pp. 37-40
Author(s):  
Vesna Savić ◽  
Milica Martinović ◽  
Ivana Nešić ◽  
Jelena Živković ◽  
Ivana Gajić
Keyword(s):  
Zinc Oxide ◽  
The Other ◽  
Stability Tests ◽  
Polysorbate 20 ◽  
The Stability ◽  
Carbomer Gel ◽  
Suspension Structure ◽  
Insight Into ◽  
Study Offer ◽  
Measured Hardness

The aim of this study was to compare the stability and texture of three zinc oxide suspensions with different additives. Suspension 1 was made as official magistral formulation Suspensio album 7.5% from Formulae magistrales 2008. Suspension 2 was prepared when 1% carbomer gel was added to suspension 1 and suspension 3 was prepared when polysorbate 20 was added to suspension 2. After stability tests, texture analysis was performed on all suspensions. Following parameters were measured: hardness cycle 1, hardness cycle 2, cohesiveness, adhesiveness, resilience and springiness. The study showed that suspension 3 had the lowest value of hardness, and therefore the best spreadability. Also, suspension 3 was the least sticky of all three, since it was characterized with the lowest adhesiveness. Further, suspension 3 was the most cohesive and is predicted to withstand the stress during packing and use longer than others. On the other hand, the highest values of resilience and springiness were detected for suspension 1, while the lowest was related to suspension 2. Therefore, the best textural characteristics were assigned to suspension 3. This result is in accordance with the results of performed stability tests. The results of our study offer insight into potential improvements of the current magistral formulation Suspensio album 7.5%.

scholarly journals Een geconstrueerd denken

1970 ◽  
Vol 61 ◽  
pp. 269-292
Author(s):  
Rajesh Heynickx
Keyword(s):  
Main Argument ◽  
Cultural Project ◽  
The Stability ◽  
Insight Into ◽  
The Way

In this article it is demonstrated that an analysis of how building metaphorswere used in the Flemish Catholic discourse of the interwar years can offermore insight into the way a community of believers tries to establish a culturalcohesiveness. The main argument is that in a period of deep transformations,building metaphors could become "instruments" for Catholics whowanted to defend and promote a traditional dimension of their religion.Building metaphors allowed Catholics to stress the stability of their own ideology(the fundaments) and to formulate their own cultural project (buildingplan). By analysing such strategic use of building metaphors in artistic andphilosophical discourses, it can become possible to shed more light on the roleneo-thomism, a main philosophical current in interwar Flanders, played inartistic debates and more specific in discussions on the modernisation of religiousart.

scholarly journals Molecular Oxygen Lignin Depolymerization: An Insight into the Stability of Phenolic Monomers

ChemSusChem ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 4743-4758
Author(s):  
Yannick Mathieu ◽  
Juan D. Vidal ◽  
Lourdes Arribas Martínez ◽  
Nerea Abad Fernández ◽  
Sara Iborra ◽  
...  
Keyword(s):  
Molecular Oxygen ◽  
The Stability ◽  
Lignin Depolymerization ◽  
Insight Into

scholarly journals Structural Stabilization of Human Transthyretin by Centella asiatica (L.) Urban Extract: Implications for TTR Amyloidosis

Biomolecules ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 128 ◽  
Author(s):  
Fredrick Nwude Eze ◽  
Ladda Leelawatwattana ◽  
Porntip Prapunpoj
Keyword(s):  
Protein Misfolding ◽  
Quaternary Structure ◽  
Centella Asiatica ◽  
Structural Stabilization ◽  
Flight Mass Spectrometry ◽  
Transmission Electron ◽  
Small Molecule Ligands ◽  
Therapeutic Development ◽  
The Stability

Transthyretin is responsible for a series of highly progressive, degenerative, debilitating, and incurable protein misfolding disorders known as transthyretin (TTR) amyloidosis. Since dissociation of the homotetrameric protein to its monomers is crucial in its amyloidogenesis, stabilizing the native tetramer from dissociating using small-molecule ligands has proven a viable therapeutic strategy. The objective of this study was to determine the potential role of the medicinal herb Centella asiatica on human transthyretin (huTTR) amyloidogenesis. Thus, we investigated the stability of huTTR with or without a hydrophilic fraction of C. asiatica (CAB) against acid/urea-mediated denaturation. We also determined the influence of CAB on huTTR fibrillation using transmission electron microscopy. The potential binding interactions between CAB and huTTR was ascertained by nitroblue tetrazolium redox-cycling and 8-anilino-1-naphthalene sulfonic acid displacement assays. Additionally, the chemical profile of CAB was determined by liquid chromatography quadruple time-of-flight mass spectrometry (HPLC-QTOF-MS). Our results strongly suggest that CAB bound to and preserved the quaternary structure of huTTR in vitro. CAB also prevented transthyretin fibrillation, although aggregate formation was unmitigated. These effects could be attributable to the presence of phenolics and terpenoids in CAB. Our findings suggest that C. asiatica contains pharmaceutically relevant bioactive compounds which could be exploited for therapeutic development against TTR amyloidosis.

How Does the Ribosome Fold the Proteome?

2020 ◽  
Vol 89 (1) ◽  
pp. 389-415 ◽  
Author(s):  
Anaïs M.E. Cassaignau ◽  
Lisa D. Cabrita ◽  
John Christodoulou
Keyword(s):  
Structural Properties ◽  
Protein Misfolding ◽  
Dynamic Properties ◽  
Protein Translation ◽  
Biologically Active ◽  
Active Structures ◽  
Protein Misfolding And Aggregation ◽  
Polypeptide Chains ◽  
Intrinsic Dynamic ◽  
Insight Into

Folding of polypeptides begins during their synthesis on ribosomes. This process has evolved as a means for the cell to maintain proteostasis, by mitigating the risk of protein misfolding and aggregation. The capacity to now depict this cellular feat at increasingly higher resolution is providing insight into the mechanistic determinants that promote successful folding. Emerging from these studies is the intimate interplay between protein translation and folding, and within this the ribosome particle is the key player. Its unique structural properties provide a specialized scaffold against which nascent polypeptides can begin to form structure in a highly coordinated, co-translational manner. Here, we examine how, as a macromolecular machine, the ribosome modulates the intrinsic dynamic properties of emerging nascent polypeptide chains and guides them toward their biologically active structures.

Role of sterics in phosphine-ligated gold clusters

2019 ◽  
Vol 21 (4) ◽  
pp. 1689-1699 ◽  
Author(s):  
Katherine A. Parrish ◽  
Mary King ◽  
Marshall R. Ligare ◽  
Grant E. Johnson ◽  
Heriberto Hernández
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Ligand Exchange ◽  
Gold Clusters ◽  
Solution Phase ◽  
Ionization Mass ◽  
Exchange Reactions ◽  
The Stability ◽  
Insight Into

This study examined the solution-phase exchange reactions of triphenylphosphine (PPh3) ligands on Au8L72+ (L = PPh3) gold clusters with three different tolyl ligands using electrospray ionization mass spectrometry to provide insight into how steric differences in the phosphines influence the extent of ligand exchange and the stability of the resulting mixed-phosphine clusters.

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