Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase†

Biochemistry ◽  
2003 ◽  
Vol 42 (36) ◽  
pp. 10569-10578 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
J. Bradley Hamilton ◽  
Elizabeth E. Howell
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
Ionic Interactions ◽  
R67 Dihydrofolate Reductase

scholarly journals Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations

2004 ◽  
Vol 279 (45) ◽  
pp. 46995-47002 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Kenneth H. Minor ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Further Studies on the Role of Water in R67 Dihydrofolate Reductase

Biochemistry ◽  
2013 ◽  
Vol 52 (12) ◽  
pp. 2118-2127 ◽  
Author(s):  
Mary Jane Timson ◽  
Michael R. Duff ◽  
Greyson Dickey ◽  
Arnold M. Saxton ◽  
José I. Reyes-De-Corcuera ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

scholarly journals “Catch 222,” the Effects of Symmetry on Ligand Binding and Catalysis in R67 Dihydrofolate Reductase as Determined by Mutations at Tyr-69

2004 ◽  
Vol 279 (45) ◽  
pp. 47003-47009 ◽  
Author(s):  
Lori G. Stinnett ◽  
R. Derike Smiley ◽  
Stephanie N. Hicks ◽  
Elizabeth E. Howell
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Role of S65, Q67, I68, and Y69 Residues in Homotetrameric R67 Dihydrofolate Reductase†

Biochemistry ◽  
2001 ◽  
Vol 40 (38) ◽  
pp. 11344-11352 ◽  
Author(s):  
Michael Brad Strader ◽  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Nathan C. VerBerkmoes ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Multiple ligand-binding modes in bacterial R67 dihydrofolate reductase

2005 ◽  
Vol 19 (3) ◽  
pp. 165-187 ◽  
Author(s):  
Hernán Alonso ◽  
Malcolm B. Gillies ◽  
Peter L. Cummins ◽  
Andrey A. Bliznyuk ◽  
Jill E. Gready
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
Binding Modes ◽  
R67 Dihydrofolate Reductase ◽  
Multiple Ligand

Calorimetric Studies of Ligand Binding in R67 Dihydrofolate Reductase†

Biochemistry ◽  
2005 ◽  
Vol 44 (37) ◽  
pp. 12420-12433 ◽  
Author(s):  
Michael Jackson ◽  
Shaileja Chopra ◽  
R. Derike Smiley ◽  
Patrick O'Neal Maynord ◽  
Andre Rosowsky ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase ◽  
Calorimetric Studies

scholarly journals Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.

1988 ◽  
Vol 263 (19) ◽  
pp. 9187-9198 ◽  
Author(s):  
J R Appleman ◽  
E E Howell ◽  
J Kraut ◽  
M Kühl ◽  
R L Blakley
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase

scholarly journals The role of Val68(E11) in ligand binding to sperm whale myoglobin. Site-directed mutagenesis of a synthetic gene.

1990 ◽  
Vol 265 (20) ◽  
pp. 11788-11795
Author(s):  
K D Egeberg ◽  
B A Springer ◽  
S G Sligar ◽  
T E Carver ◽  
R J Rohlfs ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Sperm Whale ◽  
Site Directed Mutagenesis ◽  
Synthetic Gene ◽  
Directed Mutagenesis ◽  
Sperm Whale Myoglobin
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