Role of S65, Q67, I68, and Y69 Residues in Homotetrameric R67 Dihydrofolate Reductase†

Biochemistry ◽  
2001 ◽  
Vol 40 (38) ◽  
pp. 11344-11352 ◽  
Author(s):  
Michael Brad Strader ◽  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Nathan C. VerBerkmoes ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase†

Biochemistry ◽  
2003 ◽  
Vol 42 (36) ◽  
pp. 10569-10578 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
J. Bradley Hamilton ◽  
Elizabeth E. Howell
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
Ionic Interactions ◽  
R67 Dihydrofolate Reductase

scholarly journals Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations

2004 ◽  
Vol 279 (45) ◽  
pp. 46995-47002 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Kenneth H. Minor ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

Further Studies on the Role of Water in R67 Dihydrofolate Reductase

Biochemistry ◽  
2013 ◽  
Vol 52 (12) ◽  
pp. 2118-2127 ◽  
Author(s):  
Mary Jane Timson ◽  
Michael R. Duff ◽  
Greyson Dickey ◽  
Arnold M. Saxton ◽  
José I. Reyes-De-Corcuera ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase

scholarly journals Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.

1988 ◽  
Vol 263 (19) ◽  
pp. 9187-9198 ◽  
Author(s):  
J R Appleman ◽  
E E Howell ◽  
J Kraut ◽  
M Kühl ◽  
R L Blakley
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase

scholarly journals A 1H n.m.r. study of the role of the glutamate moiety in the binding of methotrexate to Lactobacillus casei dihydrofolate reductase

1984 ◽  
Vol 81 (2) ◽  
pp. 309-315 ◽  
Author(s):  
David J. Antonjuk ◽  
Berry Birdsall ◽  
H.T. Andrew Cheung ◽  
G. Marius Clore ◽  
James Feeney ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Lactobacillus Casei

Does R67 Dihydrofolate Reductase Possess a Proton Donor?

1993 ◽  
pp. 493-498 ◽  
Author(s):  
Janel C. Holland ◽  
Charles E. Linn ◽  
Enrico DiGiammarino ◽  
Robert Nichols ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
Proton Donor ◽  
R67 Dihydrofolate Reductase
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