Petasiphenol:  A DNA Polymerase λ Inhibitor†

Biochemistry ◽  
2002 ◽  
Vol 41 (49) ◽  
pp. 14463-14471 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Shinji Kamisuki ◽  
Nobuyuki Kasai ◽  
Tomomi Ishidoh ◽  
Noriko Shimazaki ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Λ

scholarly journals Small Molecule Inhibitors of Human DNA Polymerase λ

2011 ◽  
Vol 6 (4) ◽  
pp. 314-319 ◽  
Author(s):  
Tobias Strittmatter ◽  
Bettina Bareth ◽  
Timo A. Immel ◽  
Thomas Huhn ◽  
Thomas U. Mayer ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Substrate‐induced DNA strand misalignment during catalytic cycling by DNA polymerase λ

EMBO Reports ◽  
2008 ◽  
Vol 9 (5) ◽  
pp. 459-464 ◽  
Author(s):  
Katarzyna Bebenek ◽  
Miguel Garcia‐Diaz ◽  
Meredith C Foley ◽  
Lars C Pedersen ◽  
Tamar Schlick ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Λ ◽  
Dna Strand

scholarly journals Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

2012 ◽  
Vol 41 (1) ◽  
pp. 229-241 ◽  
Author(s):  
Elisa Zucca ◽  
Federica Bertoletti ◽  
Ursula Wimmer ◽  
Elena Ferrari ◽  
Giuliano Mazzini ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Replication Stress ◽  
S Phase ◽  
Human Dna ◽  
Dna Polymerase Λ ◽  
Synthetically Lethal ◽  
S Phase Checkpoint

scholarly journals Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7290 ◽  
Author(s):  
Gloria Terrados ◽  
Jean-Pascal Capp ◽  
Yvan Canitrot ◽  
Miguel García-Díaz ◽  
Katarzyna Bebenek ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Chromosomal Instability ◽  
Human Dna ◽  
Dna Polymerase Λ

Human DNA Polymerase λ Possesses Terminal Deoxyribonucleotidyl Transferase Activity And Can Elongate RNA Primers: Implications for Novel Functions

2003 ◽  
Vol 328 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Kristijan Ramadan ◽  
Giovanni Maga ◽  
Igor V Shevelev ◽  
Giuseppe Villani ◽  
Luis Blanco ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Transferase Activity ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ

2010 ◽  
Vol 403 (4) ◽  
pp. 505-515 ◽  
Author(s):  
Jessica A. Brown ◽  
Lindsey R. Pack ◽  
Shanen M. Sherrer ◽  
Ajay K. Kshetry ◽  
Sean A. Newmister ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Tight Binding ◽  
Human Dna ◽  
Critical Residues ◽  
Dna Polymerase Λ

Hymenoic acid, a novel specific inhibitor of human DNA polymerase λ from a fungus of Hymenochaetaceae sp.

2008 ◽  
Vol 16 (9) ◽  
pp. 5115-5122 ◽  
Author(s):  
Masayuki Nishida ◽  
Noriko Ida ◽  
Mao Horio ◽  
Toshifumi Takeuchi ◽  
Shinji Kamisuki ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Specific Inhibitor ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase λ and Proliferating Cell Nuclear Antigen 2

2011 ◽  
Vol 23 (2) ◽  
pp. 806-822 ◽  
Author(s):  
Alessandra Amoroso ◽  
Lorenzo Concia ◽  
Caterina Maggio ◽  
Cécile Raynaud ◽  
Catherine Bergounioux ◽  
...  
Keyword(s):  
Dna Damage ◽  
Arabidopsis Thaliana ◽  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Oxidative Dna Damage ◽  
Nuclear Antigen ◽  
Dna Polymerase Λ ◽  
Proliferating Cell

Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans

2014 ◽  
Vol 5 (4) ◽  
pp. 696-704 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Isoko Kuriyama ◽  
Hiromi Yoshida
Keyword(s):  
Dna Polymerase ◽  
Inflammatory Activity ◽  
Soybean Extract ◽  
Dna Polymerase Λ ◽  
Anti Inflammatory ◽  
Germinated Soybean

The two glucosyl compounds from the steamed germinated soybean extract had anti-inflammatory activity based on DNA polymerase λ inhibition.

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