scholarly journals Small Molecule Inhibitors of Human DNA Polymerase λ

2011 ◽  
Vol 6 (4) ◽  
pp. 314-319 ◽  
Author(s):  
Tobias Strittmatter ◽  
Bettina Bareth ◽  
Timo A. Immel ◽  
Thomas Huhn ◽  
Thomas U. Mayer ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Base excision repair and design of small molecule inhibitors of human DNA polymerase β

2010 ◽  
Vol 67 (21) ◽  
pp. 3633-3647 ◽  
Author(s):  
Samuel H. Wilson ◽  
William A. Beard ◽  
David D. Shock ◽  
Vinod K. Batra ◽  
Nisha A. Cavanaugh ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Small Molecule ◽  
Base Excision Repair ◽  
Small Molecule Inhibitors ◽  
Excision Repair ◽  
Dna Polymerase Β ◽  
Human Dna ◽  
Base Excision

scholarly journals Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

2012 ◽  
Vol 41 (1) ◽  
pp. 229-241 ◽  
Author(s):  
Elisa Zucca ◽  
Federica Bertoletti ◽  
Ursula Wimmer ◽  
Elena Ferrari ◽  
Giuliano Mazzini ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Replication Stress ◽  
S Phase ◽  
Human Dna ◽  
Dna Polymerase Λ ◽  
Synthetically Lethal ◽  
S Phase Checkpoint

scholarly journals Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7290 ◽  
Author(s):  
Gloria Terrados ◽  
Jean-Pascal Capp ◽  
Yvan Canitrot ◽  
Miguel García-Díaz ◽  
Katarzyna Bebenek ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Chromosomal Instability ◽  
Human Dna ◽  
Dna Polymerase Λ

Human DNA Polymerase λ Possesses Terminal Deoxyribonucleotidyl Transferase Activity And Can Elongate RNA Primers: Implications for Novel Functions

2003 ◽  
Vol 328 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Kristijan Ramadan ◽  
Giovanni Maga ◽  
Igor V Shevelev ◽  
Giuseppe Villani ◽  
Luis Blanco ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Transferase Activity ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ

2010 ◽  
Vol 403 (4) ◽  
pp. 505-515 ◽  
Author(s):  
Jessica A. Brown ◽  
Lindsey R. Pack ◽  
Shanen M. Sherrer ◽  
Ajay K. Kshetry ◽  
Sean A. Newmister ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Tight Binding ◽  
Human Dna ◽  
Critical Residues ◽  
Dna Polymerase Λ

Hymenoic acid, a novel specific inhibitor of human DNA polymerase λ from a fungus of Hymenochaetaceae sp.

2008 ◽  
Vol 16 (9) ◽  
pp. 5115-5122 ◽  
Author(s):  
Masayuki Nishida ◽  
Noriko Ida ◽  
Mao Horio ◽  
Toshifumi Takeuchi ◽  
Shinji Kamisuki ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Specific Inhibitor ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Probing Conformational Changes of Human DNA Polymerase λ using Mass Spectrometry-Based Protein Footprinting

2009 ◽  
Vol 390 (3) ◽  
pp. 368-379 ◽  
Author(s):  
Jason D. Fowler ◽  
Jessica A. Brown ◽  
Mamuka Kvaratskhelia ◽  
Zucai Suo
Keyword(s):  
Mass Spectrometry ◽  
Dna Polymerase ◽  
Conformational Changes ◽  
Protein Footprinting ◽  
Human Dna ◽  
Dna Polymerase Λ

Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase λ from a fungus, Nodulisporium sp.

2007 ◽  
Vol 15 (9) ◽  
pp. 3109-3114 ◽  
Author(s):  
Shinji Kamisuki ◽  
Chisato Ishimaru ◽  
Kadohiro Onoda ◽  
Isoko Kuriyama ◽  
Noriko Ida ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Human Dna ◽  
Dna Polymerase Λ ◽  
Specific Inhibitors

scholarly journals Up-regulation of the Fidelity of Human DNA Polymerase λ by Its Non-enzymatic Proline-rich Domain

2006 ◽  
Vol 281 (28) ◽  
pp. 19038-19044 ◽  
Author(s):  
Kevin A. Fiala ◽  
Wade W. Duym ◽  
Jun Zhang ◽  
Zucai Suo
Keyword(s):  
Dna Polymerase ◽  
Rich Domain ◽  
Human Dna ◽  
Dna Polymerase Λ

Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair

DNA Repair ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Lidia V. Skosareva ◽  
Natalia A. Lebedeva ◽  
Nadejda I. Rechkunova ◽  
Alexander Kolbanovskiy ◽  
Nicholas E. Geacintov ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Adduct ◽  
Lesion Bypass ◽  
Human Dna ◽  
Dna Polymerase Λ ◽  
Base Excision
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