scholarly journals Substrate‐induced DNA strand misalignment during catalytic cycling by DNA polymerase λ

EMBO Reports ◽  
2008 ◽  
Vol 9 (5) ◽  
pp. 459-464 ◽  
Author(s):  
Katarzyna Bebenek ◽  
Miguel Garcia‐Diaz ◽  
Meredith C Foley ◽  
Lars C Pedersen ◽  
Tamar Schlick ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Λ ◽  
Dna Strand

scholarly journals Small Molecule Inhibitors of Human DNA Polymerase λ

2011 ◽  
Vol 6 (4) ◽  
pp. 314-319 ◽  
Author(s):  
Tobias Strittmatter ◽  
Bettina Bareth ◽  
Timo A. Immel ◽  
Thomas Huhn ◽  
Thomas U. Mayer ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

2012 ◽  
Vol 41 (1) ◽  
pp. 229-241 ◽  
Author(s):  
Elisa Zucca ◽  
Federica Bertoletti ◽  
Ursula Wimmer ◽  
Elena Ferrari ◽  
Giuliano Mazzini ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Replication Stress ◽  
S Phase ◽  
Human Dna ◽  
Dna Polymerase Λ ◽  
Synthetically Lethal ◽  
S Phase Checkpoint

KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells

1997 ◽  
Vol 272 (6) ◽  
pp. L1174-L1180 ◽  
Author(s):  
M. Takeoka ◽  
W. F. Ward ◽  
H. Pollack ◽  
D. W. Kamp ◽  
R. J. Panos
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Epithelial Cells ◽  
Dna Polymerase ◽  
Dna Polymerases ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
Alveolar Epithelial ◽  
Radiation Induced ◽  
Dna Strand

Administration of exogenous keratinocyte growth factor (KGF) prevents or attenuates several forms of oxidant-mediated lung injury. Because DNA damage in epithelial cells is a component of radiation pneumotoxicity, we determined whether KGF ameliorated DNA strand breaks in irradiated A549 cells. Cells were exposed to 137Cs gamma rays, and DNA damage was measured by alkaline unwinding and ethidium bromide fluorescence after a 30-min recovery period. Radiation induced a dose-dependent increase in DNA strand breaks. The percentage of double-stranded DNA after exposure to 30 Gy increased from 44.6 +/- 3.5% in untreated control cells to 61.6 +/- 5.0% in cells cultured with 100 ng/ml KGF for 24 h (P < 0.05). No reduction in DNA damage occurred when the cells were cultured with KGF but maintained at 0 degree C during and after irradiation. The sparing effect of KGF on radiation-induced DNA damage was blocked by aphidicolin, an inhibitor of DNA polymerases-alpha, -delta, and -epsilon and by butylphenyl dGTP, which blocks DNA polymerase-alpha strongly and polymerases-delta and -epsilon less effectively. However, dideoxythymidine triphosphate, a specific inhibitor of DNA polymerase-beta, did not abrogate the KGF effect. Thus KGF increases DNA repair capacity in irradiated pulmonary epithelial cells, an effect mediated at least in part by DNA polymerases-alpha, -delta, and -epsilon. Enhancement of DNA repair capability after cell damage may be one mechanism by which KGF is able to ameliorate oxidant-mediated alveolar epithelial injury.

DNA Polymerase Required for Rapid Repair of X-ray--Induced DNA Strand Breaks in vivo

Science ◽  
1971 ◽  
Vol 172 (3985) ◽  
pp. 851-854 ◽  
Author(s):  
C. D. Town ◽  
K. C. Smith ◽  
H. S. Kaplan
Keyword(s):  
Dna Polymerase ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
X Ray ◽  
Rapid Repair ◽  
Dna Strand

scholarly journals Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7290 ◽  
Author(s):  
Gloria Terrados ◽  
Jean-Pascal Capp ◽  
Yvan Canitrot ◽  
Miguel García-Díaz ◽  
Katarzyna Bebenek ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Chromosomal Instability ◽  
Human Dna ◽  
Dna Polymerase Λ

Human DNA Polymerase λ Possesses Terminal Deoxyribonucleotidyl Transferase Activity And Can Elongate RNA Primers: Implications for Novel Functions

2003 ◽  
Vol 328 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Kristijan Ramadan ◽  
Giovanni Maga ◽  
Igor V Shevelev ◽  
Giuseppe Villani ◽  
Luis Blanco ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Transferase Activity ◽  
Human Dna ◽  
Dna Polymerase Λ

scholarly journals Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ

2010 ◽  
Vol 403 (4) ◽  
pp. 505-515 ◽  
Author(s):  
Jessica A. Brown ◽  
Lindsey R. Pack ◽  
Shanen M. Sherrer ◽  
Ajay K. Kshetry ◽  
Sean A. Newmister ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Tight Binding ◽  
Human Dna ◽  
Critical Residues ◽  
Dna Polymerase Λ

Hymenoic acid, a novel specific inhibitor of human DNA polymerase λ from a fungus of Hymenochaetaceae sp.

2008 ◽  
Vol 16 (9) ◽  
pp. 5115-5122 ◽  
Author(s):  
Masayuki Nishida ◽  
Noriko Ida ◽  
Mao Horio ◽  
Toshifumi Takeuchi ◽  
Shinji Kamisuki ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Specific Inhibitor ◽  
Human Dna ◽  
Dna Polymerase Λ
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