Rotational diffusion analysis of the conformational alterations produced in plasminogen by certain antifibrinolytic amino acids

Biochemistry ◽  
1973 ◽  
Vol 12 (15) ◽  
pp. 2787-2791 ◽  
Author(s):  
Francis J. Castellino ◽  
William J. Brockway ◽  
J. Kerry Thomas ◽  
Hui-Tseh Liao ◽  
Allen B. Rawitch
Keyword(s):  
Amino Acids ◽  
Rotational Diffusion ◽  
Diffusion Analysis

Rotational Diffusion Analysis of Polyethylene Glycol Induced Protein Interactions

2011 ◽  
Vol 115 (41) ◽  
pp. 11786-11792 ◽  
Author(s):  
Daisuke Takahashi ◽  
Shoji Yamashita ◽  
Om Prakash ◽  
Etsuko Nishimoto
Keyword(s):  
Polyethylene Glycol ◽  
Protein Interactions ◽  
Rotational Diffusion ◽  
Diffusion Analysis

Analysis of rotational diffusion of coumarin laser dyes

2015 ◽  
Vol 93 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Y.F. Nadaf ◽  
C.G. Renuka
Keyword(s):  
Rotational Diffusion ◽  
Relaxation Times ◽  
Laser Dyes ◽  
Fluorescence Depolarization ◽  
Time Resolved ◽  
Diffusion Analysis ◽  
Alkane Solvents ◽  
Alcohol Solvents ◽  
Coumarin Laser Dyes ◽  
Coumarin 6

Rotational diffusion analysis of two laser dyes, coumarin 6 and coumarin 30, has been studied in alkane and alcohol solvents using steady-state and time-resolved fluorescence depolarization methods. The rotational diffusion times of these probes vary linearly as a function of viscosity over the range of temperature studied. It is observed that the rotational diffusion time measurements of molecules in alcohol and alkane have relaxation times typically on the order of picoseconds, though they are greater in alcohol than in alkane solvents. However, it was observed that coumarins rotate faster in n-hexane and n-heptane than in n-propanol and n-butanol solvents, and the observed results are discussed in the last section.

scholarly journals Protein-Protein Interaction on Lysozyme Crystallization Revealed by Rotational Diffusion Analysis

2008 ◽  
Vol 94 (11) ◽  
pp. 4484-4492 ◽  
Author(s):  
Daisuke Takahashi ◽  
Etsuko Nishimoto ◽  
Tadashi Murase ◽  
Shoji Yamashita
Keyword(s):  
Protein Interaction ◽  
Rotational Diffusion ◽  
Protein Protein Interaction ◽  
Diffusion Analysis

Homochirality as the Signature of Extra-Terrestrial Life

1997 ◽  
Vol 161 ◽  
pp. 505-510
Author(s):  
Alexandra J. MacDermott ◽  
Laurence D. Barron ◽  
Andrè Brack ◽  
Thomas Buhse ◽  
John R. Cronin ◽  
...  
Keyword(s):  
Amino Acids ◽  
Protein Synthesis ◽  
Optical Rotation ◽  
Physical Origin ◽  
Natural Choice ◽  
Rosetta Mission ◽  
Terrestrial Life ◽  
Subsurface Layers ◽  
Solar System Bodies ◽  
Origin Of Homochirality

AbstractThe most characteristic hallmark of life is its homochirality: all biomolecules are usually of one hand, e.g. on Earth life uses only L-amino acids for protein synthesis and not their D mirror images. We therefore suggest that a search for extra-terrestrial life can be approached as a Search for Extra- Terrestrial Homochirality (SETH). The natural choice for a SETH instrument is optical rotation, and we describe a novel miniaturized space polarimeter, called the SETH Cigar, which could be used to detect optical rotation as the homochiral signature of life on other planets. Moving parts are avoided by replacing the normal rotating polarizer by multiple fixed polarizers at different angles as in the eye of the bee. We believe that homochirality may be found in the subsurface layers on Mars as a relic of extinct life, and on other solar system bodies as a sign of advanced pre-biotic chemistry. We discuss the chiral GC-MS planned for the Roland lander of the Rosetta mission to a comet and conclude with theories of the physical origin of homochirality.

Hydrogen Cyanide Polymers from the Impact of Comet P/Shoemaker-Levy 9 on Jupiter

1997 ◽  
Vol 161 ◽  
pp. 179-187
Author(s):  
Clifford N. Matthews ◽  
Rose A. Pesce-Rodriguez ◽  
Shirley A. Liebman
Keyword(s):  
Amino Acids ◽  
Solar System ◽  
Hydrogen Cyanide ◽  
Nitrogen Heterocycles ◽  
Laboratory Studies ◽  
Heterogeneous Solids ◽  
The Many ◽  
Comet Halley ◽  
The Impact ◽  
By Products

AbstractHydrogen cyanide polymers – heterogeneous solids ranging in color from yellow to orange to brown to black – may be among the organic macromolecules most readily formed within the Solar System. The non-volatile black crust of comet Halley, for example, as well as the extensive orangebrown streaks in the atmosphere of Jupiter, might consist largely of such polymers synthesized from HCN formed by photolysis of methane and ammonia, the color observed depending on the concentration of HCN involved. Laboratory studies of these ubiquitous compounds point to the presence of polyamidine structures synthesized directly from hydrogen cyanide. These would be converted by water to polypeptides which can be further hydrolyzed to α-amino acids. Black polymers and multimers with conjugated ladder structures derived from HCN could also be formed and might well be the source of the many nitrogen heterocycles, adenine included, observed after pyrolysis. The dark brown color arising from the impacts of comet P/Shoemaker-Levy 9 on Jupiter might therefore be mainly caused by the presence of HCN polymers, whether originally present, deposited by the impactor or synthesized directly from HCN. Spectroscopic detection of these predicted macromolecules and their hydrolytic and pyrolytic by-products would strengthen significantly the hypothesis that cyanide polymerization is a preferred pathway for prebiotic and extraterrestrial chemistry.

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