Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].cntdot.poly[d(G-C)], and poly[d(A-T)].cntdot.poly[d(A-T)]

Biochemistry ◽  
1986 ◽  
Vol 25 (20) ◽  
pp. 5933-5940 ◽  
Author(s):  
C. R. Krishnamoorthy ◽  
Shau Fong Yen ◽  
J. C. Smith ◽  
J. William Lown ◽  
W. David Wilson
Keyword(s):  
Kinetic Analysis ◽  
Anticancer Drugs ◽  
Calf Thymus Dna ◽  
Stopped Flow ◽  
Calf Thymus

Interaction of 1,4-Dihydroxy–9,10-Anthraquinone with Calf Thymus DNA: A Comparison with Anthracycline Anticancer Drugs

2011 ◽  
Vol 40 (3) ◽  
pp. 492-501 ◽  
Author(s):  
Partha Sarathi Guin ◽  
Saurabh Das ◽  
Parikshit Chandra Mandal
Keyword(s):  
Anticancer Drugs ◽  
Calf Thymus Dna ◽  
Calf Thymus

Stopped-Flow Kinetic Studies of Poly(amidoamine) Dendrimer–Calf Thymus DNA To Form Dendriplexes

2013 ◽  
Vol 117 (44) ◽  
pp. 13767-13774 ◽  
Author(s):  
Debabrata Dey ◽  
Santosh Kumar ◽  
Souvik Maiti ◽  
Dibakar Dhara
Keyword(s):  
Kinetic Studies ◽  
Calf Thymus Dna ◽  
Stopped Flow ◽  
Calf Thymus

Interaction between calf thymus DNA and cationic bottle-brush copolymers: equilibrium and stopped-flow kinetic studies

2015 ◽  
Vol 17 (4) ◽  
pp. 2366-2377 ◽  
Author(s):  
Debabrata Dey ◽  
Chiranjit Maiti ◽  
Souvik Maiti ◽  
Dibakar Dhara
Keyword(s):  
Kinetic Studies ◽  
Calf Thymus Dna ◽  
Stopped Flow ◽  
Dna Compaction ◽  
Compaction Behavior ◽  
Calf Thymus ◽  
Bottle Brush ◽  
Kinetics Of

Polyplex formation betweenctDNA and PEGylated cationic bottle-brush copolymers: PEG influences the DNA compaction behavior and the kinetics of polyplex formation.

Molecular Transformations in DNA under the Influence of UV-radiation

2020 ◽  
Vol 04 ◽  
Author(s):  
Vigen G. Barkhudaryan ◽  
Gayane V. Ananyan ◽  
Nelli H. Karapetyan
Keyword(s):  
Uv Radiation ◽  
Uv Irradiation ◽  
Absorption Spectroscopy ◽  
Calf Thymus Dna ◽  
Dilute Solutions ◽  
Concentrated Solutions ◽  
Buffer Solution ◽  
Low Concentration ◽  
Calf Thymus ◽  
Dna Solutions

Background: The processes of destruction and crosslinking of macromolecules occur simultaneously under the influence of ultraviolet (UV) radiation in synthetic polymers, dry DNA and their concentrated solutions. Objective: The effect of UV radiation on calf thymus DNA in dilute solutions subjected to UV- irradiation was studied in this work. Method: The calf thymus DNA was studied in dilute solutions using viscometry, absorption spectroscopy and electrophoresis. Results: It was shown, that at a low concentration of DNA in the buffer solution ([DNA] = 85 μg / ml) under the influence of UV radiation, the processes of destruction of macromolecules and an increase in their flexibility predominate, which is accompanied by a gradual decrease in the viscosity of their solution. In addition, due to the low concentration of the solution, intramolecular crosslinking of macromolecules predominates, which also reduces their size and, consequently, the viscosity of the solution. Conclusion: It was concluded, that in dilute DNA solutions, due to the predominance of the processes of intramolecular crosslinking of macromolecules over intermolecular, only constant processes of decreasing the sizes of DNA macromolecules occur. As a result, its solubility remains virtually unchanged during UV irradiation. The described comments are also excellently confirmed by the results of absorption spectroscopy and electrophoresis

Ce(IV)-mediated formation of benzenediazonium ion from a non-aminoazo dye, 1-phenylazo-2-hydroxy-naphthalene (Sudan I) and its binding to DNA

1989 ◽  
Vol 54 (7) ◽  
pp. 2021-2026
Author(s):  
Marie Stiborová ◽  
Befekadu Asfaw ◽  
Pavel Anzenbacher
Keyword(s):  
Azo Dyes ◽  
Acidic Medium ◽  
Model System ◽  
Calf Thymus Dna ◽  
Suitable Model ◽  
Principal Product ◽  
Calf Thymus ◽  
Sudan I ◽  
A Minor

Ce(IV) ions in acidic medium convert a carcinogenic non-aminoazo dye, 1-phenylazo-2-hydroxy-naphthalene (Sudan I) into an ultimate carcinogen, which binds to calf thymus DNA. The principal product of Sudan I oxidation by the Ce(IV) system is the benzenediazonium ion. A minor product is the dihydroxyderivative of Sudan I, 1-(4-hydroxyphenylazo)-2,6-dihydroxynaphthalene. Other minor coloured products (yellow and brown) were not identified. The principal product (the benzenediazonium ion) is responsible for the carcinogenicity of Sudan I, as it covalently binds to DNA. Ce(IV) ions in acidic medium represent a suitable model system, which imitates the activation route of carcinogenic azo dyes.

Investigation of Anti-Cancer Drug Nimustine Interaction with Calf Thymus DNA

MAPAN ◽  
2016 ◽  
Vol 31 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Deepti Chadha ◽  
Shweta Agarwal ◽  
Ranjana Mehrotra
Keyword(s):  
Calf Thymus Dna ◽  
Cancer Drug ◽  
Calf Thymus ◽  
Anti Cancer

Studies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of Schiff bases

2017 ◽  
Vol 172 ◽  
pp. 129-138 ◽  
Author(s):  
Cleiton M. da Silva ◽  
Marina M. Silva ◽  
Fabiano S. Reis ◽  
Ana Lúcia T.G. Ruiz ◽  
João E. de Carvalho ◽  
...  
Keyword(s):  
Free Radical ◽  
Schiff Bases ◽  
Cancer Cell ◽  
Radical Scavenging ◽  
Dna Interaction ◽  
Free Radical Scavenging ◽  
Calf Thymus Dna ◽  
Calf Thymus
Sign in / Sign up

Export Citation Format

Share Document