Contribution of hydrogen bonding to the conformational stability of ribonuclease T1

Biochemistry ◽  
1992 ◽  
Vol 31 (3) ◽  
pp. 725-732 ◽  
Author(s):  
Bret A. Shirley ◽  
Patrick Stanssens ◽  
Ulrich Hahn ◽  
C. Nick Pace
Keyword(s):  
Hydrogen Bonding ◽  
Conformational Stability ◽  
Ribonuclease T1

scholarly journals Conformational stability and mechanism of folding of ribonuclease T1

1989 ◽  
Vol 264 (20) ◽  
pp. 11614-11620 ◽  
Author(s):  
J A Thomson ◽  
B A Shirley ◽  
G R Grimsley ◽  
C N Pace
Keyword(s):  
Conformational Stability ◽  
Ribonuclease T1

scholarly journals Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.

1988 ◽  
Vol 263 (24) ◽  
pp. 11820-11825 ◽  
Author(s):  
C N Pace ◽  
G R Grimsley ◽  
J A Thomson ◽  
B J Barnett
Keyword(s):  
Disulfide Bonds ◽  
Conformational Stability ◽  
Ribonuclease T1

scholarly journals Intramolecular hydrogen bonding and conformational preferences on 2-fluoro-phenylaminocyclohexanol

2018 ◽  
Author(s):  
Cassia Chiari ◽  
Claudio Francisco Tormena ◽  
Kahlil Schwanka Salome ◽  
Laiza Bruzadelle Loureiro ◽  
Renan Vidal Viesser
Keyword(s):  
Hydrogen Bonding ◽  
Driving Force ◽  
Conformational Stability ◽  
Intramolecular Hydrogen Bonding ◽  
Quantum Mechanical ◽  
Resonance Spectroscopy ◽  
Quantum Mechanical Calculations ◽  
Conformational Preferences ◽  
Intramolecular Hydrogen ◽  
Theoretical Results

The aim of this study is to evaluate the influence and strength of possible intramolecular hydrogen bonding (IntraHB) involving N-H--O, O-H--N, O-H--F and N-H--F molecular moieties as a driving force on the conformational preferences of 2-fluoro-phenylaminocyclohexanol. To achieve our purpose we synthesized the compound and performed it's characterization using Nuclear Magnetic Resonance Spectroscopy (NMR). Quantum mechanical calculations were carried out to evaluate the effect of IntraHB on the conformational stability. Experimental and theoretical results showed that N-H--F and O-H--N IntraHB have a greater influence on the conformacional preferably adopted by the molecule.

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