Structure-function analysis of the mammalian DNA polymerase .beta. active site: role of aspartic acid 256, arginine 254, and arginine 258 in nucleotidyl transfer

Karen L. Menge; Zdenek Hostomsky; Beverly R. Nodes; Geoffrey O. Hudson; Soheil Rahmati; Ellen W. Moomaw; Robert J. Almassy; Zuzana Hostomska

doi:10.1021/bi00049a008

Structure-function analysis of the mammalian DNA polymerase .beta. active site: role of aspartic acid 256, arginine 254, and arginine 258 in nucleotidyl transfer

Biochemistry ◽

10.1021/bi00049a008 ◽

1995 ◽

Vol 34 (49) ◽

pp. 15934-15942 ◽

Cited By ~ 46

Author(s):

Karen L. Menge ◽

Zdenek Hostomsky ◽

Beverly R. Nodes ◽

Geoffrey O. Hudson ◽

Soheil Rahmati ◽

...

Keyword(s):

Structure Function ◽

Aspartic Acid ◽

Dna Polymerase ◽

Active Site ◽

Function Analysis ◽

Dna Polymerase Beta ◽

Polymerase Beta

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Structure-function analysis of DNA polymerase-.beta. using monoclonal antibodies: identification of a putative nucleotide binding domain

Biochemistry ◽

10.1021/bi00149a033 ◽

1992 ◽

Vol 31 (34) ◽

pp. 7989-7997 ◽

Cited By ~ 2

Author(s):

Anthony J. Recupero ◽

Diane C. Rein ◽

Ralph R. Meyer

Keyword(s):

Monoclonal Antibodies ◽

Structure Function ◽

Dna Polymerase ◽

Function Analysis ◽

Nucleotide Binding ◽

Binding Domain ◽

Dna Polymerase Beta ◽

Nucleotide Binding Domain ◽

Polymerase Beta

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POLB: A new role of DNA polymerase beta in mitochondrial base excision repair

DNA Repair ◽

10.1016/j.dnarep.2017.11.002 ◽

2017 ◽

Vol 60 ◽

pp. A1-A5 ◽

Cited By ~ 12

Author(s):

Brett A. Kaufman ◽

Bennett Van Houten

Keyword(s):

Dna Polymerase ◽

Base Excision Repair ◽

Excision Repair ◽

Dna Polymerase Beta ◽

Polymerase Beta ◽

Base Excision

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The role of DNA polymerase beta in determining sensitivity to ionizing radiation in human tumor cells

Nucleic Acids Research ◽

10.1093/nar/gkf403 ◽

2002 ◽

Vol 30 (13) ◽

pp. 2995-3004 ◽

Cited By ~ 24

Author(s):

C. Vens

Keyword(s):

Ionizing Radiation ◽

Tumor Cells ◽

Dna Polymerase ◽

Human Tumor ◽

Dna Polymerase Beta ◽

Human Tumor Cells ◽

Polymerase Beta

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Active-site modification of mammalian DNA polymerase .beta. with pyridoxal 5'-phosphate: mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket

Biochemistry ◽

10.1021/bi00441a023 ◽

1989 ◽

Vol 28 (15) ◽

pp. 6305-6309 ◽

Cited By ~ 17

Author(s):

Amaresh Basu ◽

Padmini Kedar ◽

Samuel H. Wilson ◽

Mukund J. Modak

Keyword(s):

Dna Polymerase ◽

Active Site ◽

Binding Pocket ◽

Dna Polymerase Beta ◽

Polymerase Beta ◽

Mechanism Of Inhibition ◽

Deoxynucleoside Triphosphate

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Aspartic acid residues at positions 190 and 192 of rat DNA polymerase .beta. are involved in primer binding

Biochemistry ◽

10.1021/bi00235a023 ◽

1991 ◽

Vol 30 (21) ◽

pp. 5286-5292 ◽

Cited By ~ 32

Author(s):

Takayasu Date ◽

Setsuko Yamamoto ◽

Kiyomi Tanihara ◽

Yoshio Nishimoto ◽

Akio Matsukage

Keyword(s):

Aspartic Acid ◽

Dna Polymerase ◽

Dna Polymerase Beta ◽

Polymerase Beta

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Role of DNA polymerase beta in the genotoxicity of arsenic

Environmental and Molecular Mutagenesis ◽

10.1002/em.20643 ◽

2011 ◽

Vol 52 (6) ◽

pp. 460-468 ◽

Cited By ~ 16

Author(s):

Yanhao Lai ◽

Wei Zhao ◽

Chen Chen ◽

Mei Wu ◽

Zunzhen Zhang

Keyword(s):

Dna Polymerase ◽

Dna Polymerase Beta ◽

Polymerase Beta

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Potential role of DNA polymerase beta in gene therapy against cancer: A case for colorectal cancer

Medical Hypotheses ◽

10.1016/s0306-9877(96)90033-x ◽

1996 ◽

Vol 47 (1) ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

F.F. Shadan ◽

L.P. Villarreal

Keyword(s):

Colorectal Cancer ◽

Gene Therapy ◽

Dna Polymerase ◽

Potential Role ◽

Dna Polymerase Beta ◽

Polymerase Beta

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Faculty Opinions recommendation of Arginine methylation regulates DNA polymerase beta.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014441.371912 ◽

2006 ◽

Author(s):

Errol C Friedberg

Keyword(s):

Dna Polymerase ◽

Arginine Methylation ◽

Dna Polymerase Beta ◽

Polymerase Beta

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Faculty Opinions recommendation of DNA polymerase beta participates in mitochondrial DNA repair.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727675498.793533615 ◽

2017 ◽

Author(s):

Aishwarya Prakash

Keyword(s):

Dna Repair ◽

Mitochondrial Dna ◽

Dna Polymerase ◽

Dna Polymerase Beta ◽

Polymerase Beta ◽

Mitochondrial Dna Repair

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In vitro replication of mitochondrial DNA. Elongation of the endogenous primer sequence in D loop mitochondrial DNA by human DNA polymerase beta.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)41048-9 ◽

1977 ◽

Vol 252 (21) ◽

pp. 7888-7893

Author(s):

D.C. Eichler ◽

T.S. Wang ◽

D.A. Clayton ◽

D. Korn

Keyword(s):

Mitochondrial Dna ◽

Dna Polymerase ◽

Dna Polymerase Beta ◽

Polymerase Beta ◽

Human Dna ◽

In Vitro Replication ◽

D Loop ◽

Primer Sequence

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