Groove Binding Ligands for the Interaction with Parallel-Strandedps-Duplex DNA and Triplex DNA

2010 ◽  
Vol 21 (8) ◽  
pp. 1389-1403 ◽  
Author(s):  
Akash K. Jain ◽  
Santanu Bhattacharya
Keyword(s):  
Triplex Dna ◽  
Duplex Dna ◽  
Groove Binding

Preferential binding of anticancer drugs to triplex DNA compared to duplex DNA: a spectroscopic and calorimetric study

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 39903-39917 ◽  
Author(s):  
Neelam Lohani ◽  
Moganty R. Rajeswari
Keyword(s):  
Anticancer Drugs ◽  
Promoter Region ◽  
Binding Study ◽  
Triplex Dna ◽  
Calorimetric Study ◽  
Duplex Dna ◽  
Calorimetric Technique ◽  
Preferential Binding

Binding study of adriamycin and actinomycin to triplex DNA formed on the promoter region of hmgb1 gene using spectroscopic and calorimetric technique.

scholarly journals Selectivity of a bromoacridine-containing fluorophore for triplex DNA

2021 ◽  
Author(s):  
Sanjeev Kumar Sharma ◽  
William Fraser
Keyword(s):  
Dna Sequences ◽  
Bromine Atom ◽  
Triplex Dna ◽  
Target Sequence ◽  
Duplex Dna ◽  
Synthetic Route

AbstractFluorophore 1,8-naphthilamide was linked to 2-bromoacridine through an ethylenediamine spacer using a succinct synthetic route to give a bromoacridine-linked, bifunctional fluorophore conjugate for the detection of triplex DNA. Acridine is well known to intercalate into duplex DNA whereas introduction of a bulky bromine atom at position C2 redirects specificity for triplex over duplex DNA. In this work, photoelectron transfer assay was used to demonstrate that the synthesised 2-bromoacridine-linked fluorophore conjugate had good selectivity for the representative triplex DNA target sequence d(T*A.T)20 compared with double-stranded d(T.A)20, single-stranded dT20 or d(G/A)19 DNA sequences. Graphic abstract

Photoactive RuII-Polypyridyl Complexes that Display Sequence Selectivity and High-Affinity Binding to Duplex DNA through Groove Binding

2011 ◽  
Vol 17 (7) ◽  
pp. 2089-2098 ◽  
Author(s):  
Amrita Ghosh ◽  
Priyadip Das ◽  
Martin R. Gill ◽  
Prasenjit Kar ◽  
Michael G. Walker ◽  
...  
Keyword(s):  
Affinity Binding ◽  
Duplex Dna ◽  
Groove Binding ◽  
Polypyridyl Complexes ◽  
High Affinity Binding ◽  
Display Sequence ◽  
High Affinity ◽  
Sequence Selectivity

Targeting duplex DNA with DNA-PNA chimeras? Physico-chemical characterization of a triplex DNA-PNA/DNA/DNA

Biopolymers ◽  
2004 ◽  
Vol 73 (4) ◽  
pp. 434-442 ◽  
Author(s):  
L. Petraccone ◽  
E. Erra ◽  
A. Messere ◽  
D. Montesarchio ◽  
G. Piccialli ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Triplex Dna ◽  
Duplex Dna ◽  
Physico Chemical

Development of novel C-nucleoside analogues for the formation of antiparallel-type triplex DNA with duplex DNA that includes TA and dUA base pairs

2020 ◽  
Vol 18 (15) ◽  
pp. 2845-2851 ◽  
Author(s):  
Yosuke Taniguchi ◽  
Yuya Magata ◽  
Takayuki Osuki ◽  
Ryotaro Notomi ◽  
Lei Wang ◽  
...  
Keyword(s):  
Nucleoside Analogues ◽  
Triplex Dna ◽  
Duplex Dna ◽  
Base Pairs

We report the formation of stable triplex DNA for TA duplex sites by using triplex-forming oligonucleotides (TFOs) with novel C-nucleoside analogues.

scholarly journals Oligodeoxynucleotide Containing Disulphide Bond Stabilizes Triplex DNA Structure

2011 ◽  
Vol 8 (2) ◽  
pp. 507-512 ◽  
Author(s):  
Ajay Kumar
Keyword(s):  
Melting Temperature ◽  
Dna Structure ◽  
Disulphide Bond ◽  
Triplex Dna ◽  
Duplex Dna ◽  
Ph Values ◽  
Triplex Formation ◽  
The Stability ◽  
Better Than

The triplex formation of disulphide containing oligonucleotide with duplex DNA using melting temperature studies is reported. The stability of the triplex formed with disulphide containing oligonucleotide was compared with unmodified oligonucleotide and C-5 propyne deoxyuridine containing oligonucleotide. Melting temperature (Tm) values of the triplexes formed with disulphide containing oligonucleotide were found to be 37°C and 46°C at pH 7 and 6 respectively. The triplexes formed with C-5 propyne deoxyuridine substituted oligonucleotide showed Tmvalues at 27°C and 42°C at pH 7 and 6. The Tmvalues of the triplexes formed with unmodified oligonucleotide were found to be 18°C and 32°C at pH 7 and 6 respectively. This clearly demonstrates that disulphide containing oligonucleotide stabilzes triplex DNA structure better than unmodified oligonucleotide as well as C-5 propyne deoxyuridine containing oligonucleotide when targeted with duplex DNA at both the mentioned pH values.

RecA protein mediates homologous recognition via non-Watson-Crick bonds in base triplets

1995 ◽  
Vol 347 (1319) ◽  
pp. 5-12 ◽  
Keyword(s):  
Biological Significance ◽  
Reca Protein ◽  
Triplex Dna ◽  
Duplex Dna ◽  
The Novel ◽  
Hydrophobic Core ◽  
Dna Interactions ◽  
Homologous Proteins ◽  
Widespread Distribution ◽  
E Coli

E. coli RecA protein, the prototype of a class, forms a helical nucleoprotein filament on single-stranded DNA that recognizes homology in duplex DNA, and initiates the exchange of strands in homologous recombination. The discovery of this reaction some years ago posed a quandary on how a third strand recognizes homology in duplex DNA, whose Watson-Crick bonds face inward in a hydrophobic core of stacked bases. Recent studies have shown that RecA protein promotes homologous recognition via nonW atson-Crick bonds in base triplets. The intermediates in the RecA reaction differ distinctly from triplex DNA that forms non-enzymically. The biological significance of the novel set of DNA interactions by which RecA protein effects homologous recognition is indicated by the importance of this protein in recombination, and the widespread distribution of homologous proteins in prokaryotes and eukaryotes.

scholarly journals Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21390-21396
Author(s):  
Ryotaro Notomi ◽  
Lei Wang ◽  
Shigeki Sasaki ◽  
Yosuke Taniguchi
Keyword(s):  
Base Pair ◽  
Purine Nucleoside ◽  
Nucleoside Analogues ◽  
Triplex Dna ◽  
Duplex Dna ◽  
Design And Synthesis ◽  
Direct Recognition ◽  
First Time ◽  
Parallel Type

We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation.

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