scholarly journals Activatable Near-Infrared Fluorescent Probe for In Vivo Imaging of Fibroblast Activation Protein-alpha

2012 ◽  
Vol 23 (8) ◽  
pp. 1704-1711 ◽  
Author(s):  
Jinbo Li ◽  
Kai Chen ◽  
Hongguang Liu ◽  
Kai Cheng ◽  
Meng Yang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Fibroblast Activation ◽  
Fibroblast Activation Protein Alpha

A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging

2018 ◽  
Vol 6 (10) ◽  
pp. 1449-1451 ◽  
Author(s):  
Jie Xing ◽  
Qiuyu Gong ◽  
Ruifen Zou ◽  
Zihou Li ◽  
Yuanzhi Xia ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Cell Detection ◽  
Fibroblast Activation ◽  
Design And Synthesis ◽  
Cancer Cell Detection

Design and synthesis of a novel fibroblast activation protein “off–on” near-infrared fluorescent probe for cell detection, in vitro and in vivo imaging.

In Vivo Imaging of Fibroblast Activity Using a 68Ga-Labeled Fibroblast Activation Protein Alpha (FAP-α) Inhibitor

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xueying Zhang ◽  
Daoyun Chen ◽  
John W. Babich ◽  
Samuel J.E. Green ◽  
Xiang-Hua Deng ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Fibroblast Activation Protein ◽  
Fibroblast Activation ◽  
Fibroblast Activation Protein Alpha

scholarly journals Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryoichi Katsube ◽  
Kazuhiro Noma ◽  
Toshiaki Ohara ◽  
Noriyuki Nishiwaki ◽  
Teruki Kobayashi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Therapeutic Resistance ◽  
Fibroblast Activation ◽  
Human Esophageal Cancer

AbstractCancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that uses a highly selective monoclonal antibody (mAb)-photosensitizer conjugate. We developed fibroblast activation protein (FAP)-targeted NIR-PIT, in which IR700 was conjugated to a FAP-specific antibody to target CAFs (CAFs-targeted NIR-PIT: CAFs-PIT). Thus, we hypothesized that the control of CAFs could overcome the resistance to conventional chemotherapy in esophageal cancer (EC). In this study, we evaluated whether EC cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by CAFs. Next, we assessed whether the resistance could be rescued by eliminating CAF stimulation by CAFs-PIT in vitro and in vivo. Cancer cells acquired chemoradiotherapy resistance via CAF stimulation in vitro and 5-fluorouracil (FU) resistance in CAF-coinoculated tumor models in vivo. CAF stimulation promoted the migration/invasion of cancer cells and a stem-like phenotype in vitro, which were rescued by elimination of CAF stimulation. CAFs-PIT had a highly selective effect on CAFs in vitro. Finally, CAF elimination by CAFs-PIT in vivo demonstrated that the combination of 5-FU and NIR-PIT succeeded in producing 70.9% tumor reduction, while 5-FU alone achieved only 13.3% reduction, suggesting the recovery of 5-FU sensitivity in CAF-rich tumors. In conclusion, CAFs-PIT could overcome therapeutic resistance via CAF elimination. The combined use of novel targeted CAFs-PIT with conventional anticancer treatments can be expected to provide a more effective and sensible treatment strategy.

A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation

2018 ◽  
Vol 265 ◽  
pp. 582-590 ◽  
Author(s):  
Yuezheng Ti ◽  
Ling Yu ◽  
Yao Tang ◽  
Tongxia Jin ◽  
Ming Yang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Cyclooxygenase 2

Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N

2017 ◽  
Vol 53 (68) ◽  
pp. 9438-9441 ◽  
Author(s):  
Xinyuan He ◽  
Yiming Hu ◽  
Wen Shi ◽  
Xiaohua Li ◽  
Huimin Ma
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Aminopeptidase N ◽  
Design Synthesis ◽  
First Time

We have, for the first time, developed a near-infrared fluorescent probe for aminopeptidase N by combining a hemicyanine and an alanyl residue.

A Selective Near-Infrared Fluorescent Probe for In Vivo Imaging of Thiophenols from a Focused Library

2016 ◽  
Vol 11 (24) ◽  
pp. 3575-3582 ◽  
Author(s):  
Yue Pan ◽  
Tian-Bing Ren ◽  
Dan Cheng ◽  
Ze-Bing Zeng ◽  
Lin Yuan ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared

In vivo imaging of alkaline phosphatase in tumor-bearing mouse model by a promising near-infrared fluorescent probe

Talanta ◽  
2017 ◽  
Vol 175 ◽  
pp. 421-426 ◽  
Author(s):  
Hong-Wen Liu ◽  
Xiao-Xiao Hu ◽  
Longmin Zhu ◽  
Ke Li ◽  
Qiming Rong ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Mouse Model ◽  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing

In vivo imaging of hypoxia generation stimulated by testosterone using a micelle-based near-infrared fluorescent probe

2019 ◽  
Vol 288 ◽  
pp. 543-551 ◽  
Author(s):  
Yanxia Nan ◽  
Qiulan Zhou ◽  
Wenjie Zhao ◽  
Yanbing Lu ◽  
Weijian Xu
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared
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