Design, Evaluation, and Comparison of Ghrelin Receptor Agonists and Inverse Agonists as Suitable Radiotracers for PET Imaging

2012 ◽  
Vol 23 (4) ◽  
pp. 771-784 ◽  
Author(s):  
Constance Chollet ◽  
Ralf Bergmann ◽  
Jens Pietzsch ◽  
Annette G. Beck-Sickinger
Keyword(s):  
Pet Imaging ◽  
Design Evaluation ◽  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Receptor Agonists

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor

2012 ◽  
Vol 22 (13) ◽  
pp. 4281-4287 ◽  
Author(s):  
Daniel W. Kung ◽  
Steven B. Coffey ◽  
Ryan M. Jones ◽  
Shawn Cabral ◽  
Wenhua Jiao ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Ghrelin Receptor

scholarly journals Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging

2020 ◽  
Vol 82-83 ◽  
pp. 49-56
Author(s):  
Christian Borch Jacobsen ◽  
René Raavé ◽  
Marie Østergaard Pedersen ◽  
Pierre Adumeau ◽  
Mathieu Moreau ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Receptor Agonists

scholarly journals Diabetic Gastroparesis

2019 ◽  
Vol 40 (5) ◽  
pp. 1318-1352 ◽  
Author(s):  
Adil E Bharucha ◽  
Yogish C Kudva ◽  
David O Prichard
Keyword(s):  
Glycemic Control ◽  
Gastrointestinal Symptoms ◽  
Outlet Obstruction ◽  
Diabetic Gastroparesis ◽  
Oral Nutrition ◽  
Ghrelin Receptor ◽  
Receptor Agonists ◽  
Wireless Motility Capsule ◽  
Upper Gastrointestinal Symptoms

AbstractThis review covers the epidemiology, pathophysiology, clinical features, diagnosis, and management of diabetic gastroparesis, and more broadly diabetic gastroenteropathy, which encompasses all the gastrointestinal manifestations of diabetes mellitus. Up to 50% of patients with type 1 and type 2 DM and suboptimal glycemic control have delayed gastric emptying (GE), which can be documented with scintigraphy, 13C breath tests, or a wireless motility capsule; the remainder have normal or rapid GE. Many patients with delayed GE are asymptomatic; others have dyspepsia (i.e., mild to moderate indigestion, with or without a mild delay in GE) or gastroparesis, which is a syndrome characterized by moderate to severe upper gastrointestinal symptoms and delayed GE that suggest, but are not accompanied by, gastric outlet obstruction. Gastroparesis can markedly impair quality of life, and up to 50% of patients have significant anxiety and/or depression. Often the distinction between dyspepsia and gastroparesis is based on clinical judgement rather than established criteria. Hyperglycemia, autonomic neuropathy, and enteric neuromuscular inflammation and injury are implicated in the pathogenesis of delayed GE. Alternatively, there are limited data to suggest that delayed GE may affect glycemic control. The management of diabetic gastroparesis is guided by the severity of symptoms, the magnitude of delayed GE, and the nutritional status. Initial options include dietary modifications, supplemental oral nutrition, and antiemetic and prokinetic medications. Patients with more severe symptoms may require a venting gastrostomy or jejunostomy and/or gastric electrical stimulation. Promising newer therapeutic approaches include ghrelin receptor agonists and selective 5-hydroxytryptamine receptor agonists.

Cognitive enhancing effects of ghrelin receptor agonists

2009 ◽  
Vol 206 (3) ◽  
pp. 415-427 ◽  
Author(s):  
Zeenat Atcha ◽  
Woei-Shin Chen ◽  
Agnes B. Ong ◽  
Fong-Kuan Wong ◽  
Aveline Neo ◽  
...  
Keyword(s):  
Ghrelin Receptor ◽  
Receptor Agonists

Strategy for the Identification of GPR23/LPA4 Receptor Agonists and Inverse Agonists

2010 ◽  
Vol 8 (4) ◽  
pp. 459-470 ◽  
Author(s):  
Soo Hang Wong ◽  
Rommel Mallari ◽  
Melissa Graham ◽  
Larissa Atangan ◽  
Shu-Chen Lu ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Receptor Agonists
Sign in / Sign up

Export Citation Format

Share Document