Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor

2012 ◽  
Vol 22 (13) ◽  
pp. 4281-4287 ◽  
Author(s):  
Daniel W. Kung ◽  
Steven B. Coffey ◽  
Ryan M. Jones ◽  
Shawn Cabral ◽  
Wenhua Jiao ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Ghrelin Receptor

Ghrelin Receptor Inverse Agonists: Identification of an Active Peptide Core and Its Interaction Epitopes on the Receptor

2006 ◽  
Vol 70 (3) ◽  
pp. 936-946 ◽  
Author(s):  
Birgitte Holst ◽  
Manja Lang ◽  
Erik Brandt ◽  
Anders Bach ◽  
Andrew Howard ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Active Peptide ◽  
Peptide Core

Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists

2014 ◽  
Vol 57 (21) ◽  
pp. 8671-8691 ◽  
Author(s):  
Kimberly O. Cameron ◽  
Samit K. Bhattacharya ◽  
A. Katrina Loomis
Keyword(s):  
Small Molecule ◽  
Inverse Agonists ◽  
Ghrelin Receptor

scholarly journals Ghrelin receptor inverse agonists as a novel therapeutic approach against obesity‐related metabolic disease

2017 ◽  
Vol 19 (12) ◽  
pp. 1740-1750 ◽  
Author(s):  
Kathrin Abegg ◽  
Lara Bernasconi ◽  
Melanie Hutter ◽  
Lynda Whiting ◽  
Claudio Pietra ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Therapeutic Approach ◽  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Novel Therapeutic

Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model

2015 ◽  
Vol 23 (15) ◽  
pp. 4792-4803 ◽  
Author(s):  
Bitoku Takahashi ◽  
Hideaki Funami ◽  
Takehiko Iwaki ◽  
Hiroshi Maruoka ◽  
Makoto Shibata ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Orally Active

Design, Evaluation, and Comparison of Ghrelin Receptor Agonists and Inverse Agonists as Suitable Radiotracers for PET Imaging

2012 ◽  
Vol 23 (4) ◽  
pp. 771-784 ◽  
Author(s):  
Constance Chollet ◽  
Ralf Bergmann ◽  
Jens Pietzsch ◽  
Annette G. Beck-Sickinger
Keyword(s):  
Pet Imaging ◽  
Design Evaluation ◽  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Receptor Agonists

scholarly journals Structural Optimization of Ghrelin Receptor Inverse Agonists to Improve Lipophilicity and Avoid Mechanism-Based CYP3A4 Inactivation

2015 ◽  
Vol 63 (10) ◽  
pp. 825-832 ◽  
Author(s):  
Bitoku Takahashi ◽  
Hideaki Funami ◽  
Makoto Shibata ◽  
Hiroshi Maruoka ◽  
Makoto Koyama ◽  
...  
Keyword(s):  
Structural Optimization ◽  
Inverse Agonists ◽  
Ghrelin Receptor

2-Aminoalkyl nicotinamide derivatives as pure inverse agonists of the ghrelin receptor

2015 ◽  
Vol 25 (13) ◽  
pp. 2707-2712 ◽  
Author(s):  
Bitoku Takahashi ◽  
Hideaki Funami ◽  
Takehiko Iwaki ◽  
Hiroshi Maruoka ◽  
Asako Nagahira ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Nicotinamide Derivatives

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

2013 ◽  
Vol 23 (19) ◽  
pp. 5410-5414 ◽  
Author(s):  
Kim F. McClure ◽  
Margaret Jackson ◽  
Kimberly O. Cameron ◽  
Daniel W. Kung ◽  
David A. Perry ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Ghrelin Receptor

Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists

2018 ◽  
Vol 33 (1) ◽  
pp. 518-531 ◽  
Author(s):  
Valerie T. Ramirez ◽  
Wesley E. P. A. Van Oeffelen ◽  
Cristina Torres-Fuentes ◽  
Barbara Chruścicka ◽  
Clementine Druelle ◽  
...  
Keyword(s):  
Functional Selectivity ◽  
Receptor Antagonists ◽  
Inverse Agonists ◽  
Ghrelin Receptor ◽  
Downstream Signaling
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