scholarly journals Dendrons with Spermine Surface Groups as Potential Building Blocks for Nonviral Vectors in Gene Therapy

2006 ◽  
Vol 17 (1) ◽  
pp. 172-178 ◽  
Author(s):  
John G. Hardy ◽  
Mauri A. Kostiainen ◽  
David K. Smith ◽  
Nathan P. Gabrielson ◽  
Daniel W. Pack
Keyword(s):  
Gene Therapy ◽  
Building Blocks ◽  
Surface Groups ◽  
Nonviral Vectors

scholarly journals Gene Therapy Delivery Systems for Enhancing Viral and Nonviral Vectors for Cardiac Diseases: Current Concepts and Future Applications

2013 ◽  
Vol 24 (11) ◽  
pp. 914-927 ◽  
Author(s):  
Michael G. Katz ◽  
Anthony S. Fargnoli ◽  
Richard D. Williams ◽  
Charles R. Bridges
Keyword(s):  
Gene Therapy ◽  
Delivery Systems ◽  
Cardiac Diseases ◽  
Nonviral Vectors ◽  
Therapy Delivery

scholarly journals Converting cellulose nanocrystals into photocatalysts by functionalisation with titanium dioxide nanorods and gold nanocrystals

RSC Advances ◽  
2020 ◽  
Vol 10 (61) ◽  
pp. 37374-37381
Author(s):  
Santhosh S. Nair ◽  
Jianhong Chen ◽  
Adam Slabon ◽  
Aji P. Mathew
Keyword(s):  
Titanium Dioxide ◽  
Surface Charge ◽  
Water Purification ◽  
Cellulose Nanocrystals ◽  
High Surface ◽  
High Surface Area ◽  
Building Blocks ◽  
Surface Groups ◽  
Gold Nanocrystals ◽  
Titanium Dioxide Nanorods

Cellulose nanocrystals (CNCs) are promising building blocks for water purification due to their high surface area, tuneability of surface charge and grafting of surface groups depending on the pollutants.

Synthetic zinc finger peptides: old and novel applications

2004 ◽  
Vol 82 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Nicoletta Corbi ◽  
Valentina Libri ◽  
Annalisa Onori ◽  
Claudio Passananti
Keyword(s):  
Gene Therapy ◽  
Zinc Finger ◽  
Chromatin Modification ◽  
Building Blocks ◽  
Artificial Transcription Factor ◽  
Finger Peptides ◽  
Finger Recognition ◽  
Novel Applications ◽  
Recognition Code ◽  
At Will

In the last decade, the efforts in clarifying the interaction between zinc finger proteins and DNA targets strongly stimulated the creativity of scientists in the field of protein engineering. In particular, the versatility and the modularity of zinc finger (ZF) motives make these domains optimal building blocks for generating artificial zinc finger peptides (ZFPs). ZFPs can act as transcription modulators potentially able to control the expression of any desired gene, when fused to an appropriate effector domain. Artificial ZFPs open the possibility to re-program the expression of specific genes at will and can represent a powerful tool in basic science, biotechnology and gene therapy. In this review we will focus on old, novel and possible future applications of artificial ZFPs.Key words: synthetic zinc finger, recognition code, artificial transcription factor, chromatin modification, gene therapy.

scholarly journals Multicomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy

2012 ◽  
pp. 303 ◽  
Author(s):  
Aritz Perez Ruiz de Garibay ◽  
Delgado ◽  
Ana del Pozo ◽  
Mª Angeles Solinís ◽  
Alicia Rodriguez Gascón
Keyword(s):  
Gene Therapy ◽  
Fabry Disease ◽  
Nonviral Vectors

Current Status of Nonviral Vectors for Gene Therapy in China

2018 ◽  
Vol 29 (2) ◽  
pp. 110-120 ◽  
Author(s):  
Li Liu ◽  
Jingyun Yang ◽  
Ke Men ◽  
Zhiyao He ◽  
Min Luo ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Current Status ◽  
Nonviral Vectors

scholarly journals Nonviral Gene Therapy for Cancer: A Review

Diseases ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 57 ◽  
Author(s):  
Chiaki Hidai ◽  
Hisataka Kitano
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Viral Vectors ◽  
Viral Vector ◽  
Transfer Efficiency ◽  
Nonviral Vectors ◽  
Apparent Lack ◽  
Gene Transfer Efficiency ◽  
Relative Safety

Although the development of effective viral vectors put gene therapy on the road to commercialization, nonviral vectors show promise for practical use because of their relative safety and lower cost. A significant barrier to the use of nonviral vectors, however, is that they have not yet proven effective. This apparent lack of interest can be attributed to the problem of the low gene transfer efficiency associated with nonviral vectors. The efficiency of gene transfer via nonviral vectors has been reported to be 1/10th to 1/1000th that of viral vectors. Despite the fact that new gene transfer methods and nonviral vectors have been developed, no significant improvements in gene transfer efficiency have been achieved. Nevertheless, some notable progress has been made. In this review, we discuss studies that report good results using nonviral vectors in vivo in animal models, with a particular focus on studies aimed at in vivo gene therapy to treat cancer, as this disease has attracted the interest of researchers developing nonviral vectors. We describe the conditions in which nonviral vectors work more efficiently for gene therapy and discuss how the goals might differ for nonviral versus viral vector development and use.

The cubic polyhedral oligomeric silsesquioxanes based hybrid materials have a wide variety of applications, including drug administration, gene therapy, biological imaging, and bone regeneration

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Gene Therapy ◽  
Bone Regeneration ◽  
Hybrid Materials ◽  
Drug Administration ◽  
Self Assembly ◽  
Building Blocks ◽  
Research Field ◽  
Biological Imaging ◽  
High Symmetry ◽  
Polyhedral Oligomeric Silsesquioxanes

The cubic polyhedral oligomeric silsesquioxanes (POSS), which has a well-defined compact frame, high symmetry, and various modified organic substitutes, has received much interest as one of the most critical building blocks for hybrid nanomaterials and self-assembly driven amphiphilics. This work assessed current molecular design advances, solution self-assembly capabilities, and anticipated biological applications of POSS-based hybrid materials. By adopting controlled/living polymerization techniques and considerable advancements in efficient chemical coupling techniques, preparation techniques for topological POSS-based hybrid materials have become a rapidly increasing research field with future advances. The resultant POSS hybrids with various functional groups help to create complicated, unique self-assembled morphologies in solutions, induced by discrete intermolecular interactions. POSS-based hybrid materials have a wide variety of applications, including drug administration, gene therapy, biological imaging, and bone regeneration, due to their particular benefits (such as high biocompatibility, low cytototoxicity, and good degradability) and simplicity of self-assembly behaviour.

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