Synthetic zinc finger peptides: old and novel applications

2004 ◽  
Vol 82 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Nicoletta Corbi ◽  
Valentina Libri ◽  
Annalisa Onori ◽  
Claudio Passananti
Keyword(s):  
Gene Therapy ◽  
Zinc Finger ◽  
Chromatin Modification ◽  
Building Blocks ◽  
Artificial Transcription Factor ◽  
Finger Peptides ◽  
Finger Recognition ◽  
Novel Applications ◽  
Recognition Code ◽  
At Will

In the last decade, the efforts in clarifying the interaction between zinc finger proteins and DNA targets strongly stimulated the creativity of scientists in the field of protein engineering. In particular, the versatility and the modularity of zinc finger (ZF) motives make these domains optimal building blocks for generating artificial zinc finger peptides (ZFPs). ZFPs can act as transcription modulators potentially able to control the expression of any desired gene, when fused to an appropriate effector domain. Artificial ZFPs open the possibility to re-program the expression of specific genes at will and can represent a powerful tool in basic science, biotechnology and gene therapy. In this review we will focus on old, novel and possible future applications of artificial ZFPs.Key words: synthetic zinc finger, recognition code, artificial transcription factor, chromatin modification, gene therapy.

Adjacent zinc-finger motifs in multiple zinc-finger peptides from SWI5 form structurally independent, flexibly linked domains

1992 ◽  
Vol 228 (2) ◽  
pp. 619-636 ◽  
Author(s):  
Yukinobu Nakaseko ◽  
David Neuhaus ◽  
Aaron Klug ◽  
Daniela Rhodes
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Motifs ◽  
Finger Peptides

scholarly journals Design, synthesis, and characterization of novel nanowire structures for photovoltaics and intracellular probes

2011 ◽  
Vol 83 (12) ◽  
pp. 2153-2169 ◽  
Author(s):  
Bozhi Tian ◽  
Charles M. Lieber
Keyword(s):  
Critical Role ◽  
Physical Property ◽  
Building Blocks ◽  
Materials Synthesis ◽  
Design Synthesis ◽  
Unique System ◽  
Challenges And Opportunities ◽  
Iterative Control ◽  
Novel Applications

Semiconductor nanowires (NWs) represent a unique system for exploring phenomena at the nanoscale and are expected to play a critical role in future electronic, optoelectronic, and miniaturized biomedical devices. Modulation of the composition and geometry of nanostructures during growth could encode information or function, and realize novel applications beyond the conventional lithographical limits. This review focuses on the fundamental science aspects of the bottom-up paradigm, which are synthesis and physical property characterization of semiconductor NWs and NW heterostructures, as well as proof-of-concept device concept demonstrations, including solar energy conversion and intracellular probes. A new NW materials synthesis is discussed and, in particular, a new “nano-tectonic” approach is introduced that provides iterative control over the NW nucleation and growth for constructing 2D kinked NW superstructures. The use of radial and axial p-type/intrinsic/n-type (p-i-n) silicon NW (Si-NW) building blocks for solar cells and nanoscale power source applications is then discussed. The critical benefits of such structures and recent results are described and critically analyzed, together with some of the diverse challenges and opportunities in the near future. Finally, results are presented on several new directions, which have recently been exploited in interfacing biological systems with NW devices.

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