Switchable Reconfiguration of Nucleic Acid Nanostructures by Stimuli-Responsive DNA Machines

2014 ◽  
Vol 47 (6) ◽  
pp. 1673-1680 ◽  
Author(s):  
Xiaoqing Liu ◽  
Chun-Hua Lu ◽  
Itamar Willner
Keyword(s):  
Nucleic Acid ◽  
Stimuli Responsive ◽  
Dna Machines

scholarly journals Rational Design of Programmable Monodisperse Semi-Synthetic Protein Nanomaterials Containing Engineered Disulfide Functionality

2021 ◽  
Author(s):  
Pavankumar Janardhan Bhandari ◽  
Britto S Sandanaraj
Keyword(s):  
Nucleic Acid ◽  
Disulfide Bond ◽  
Rational Design ◽  
Inorganic Nanoparticles ◽  
Stimuli Responsive ◽  
Protein Assemblies ◽  
Intelligent Materials ◽  
Synthetic Protein ◽  
Responsive Behavior ◽  
Reversible Nature

AbstractThe reversible nature of disulfide functionality has been exploited to design intelligent materials such as nanocapsules, micelles, vesicles, inorganic nanoparticles, peptide and nucleic acid nanodevices. However, to our knowledge, there are no reports on design of semi-synthetic protein assemblies containing an engineered disulfide bond. Towards that end, herein, we disclose a new chemical methodology for the construction redox-sensitive protein assemblies using monodisperse facially amphiphilic protein-dendron bioconjugates. The disulfide functionality is strategically placed between the dendron and protein domains. The custom designed bioconjugates self-assembled into nanoscopic objects of a defined size dictated by the nature of dendron domain. The stimuli-responsive behavior of the protein assemblies is demonstrated using a suitable redox trigger.

Intelligent nucleic acid delivery systems based on stimuli-responsive polymers

Soft Matter ◽  
2010 ◽  
Vol 6 (5) ◽  
pp. 835-848 ◽  
Author(s):  
Fu-Sheng Du ◽  
Yang Wang ◽  
Rui Zhang ◽  
Zi-Chen Li
Keyword(s):  
Nucleic Acid ◽  
Delivery Systems ◽  
Nucleic Acid Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

scholarly journals Stimuli-responsive nucleic acid-functionalized metal–organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks

2017 ◽  
Vol 8 (8) ◽  
pp. 5769-5780 ◽  
Author(s):  
Wei-Hai Chen ◽  
Xu Yu ◽  
Alessandro Cecconello ◽  
Yang Sung Sohn ◽  
Rachel Nechushtai ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Metal Ion ◽  
Metal Organic Framework ◽  
Stimuli Responsive ◽  
Metal Organic ◽  
Organic Framework

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by pH or Mg2+ ions/ATP triggers, resulting in the release of the loads.

Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics

2015 ◽  
Vol 11 (6) ◽  
pp. 1575-1584 ◽  
Author(s):  
Fatemeh Movahedi ◽  
Rebecca G. Hu ◽  
David L. Becker ◽  
Chenjie Xu
Keyword(s):  
Nucleic Acid ◽  
Stimuli Responsive ◽  
Nucleic Acid Therapeutics

Functional nucleic acid nanostructures and DNA machines

2010 ◽  
Vol 21 (4) ◽  
pp. 376-391 ◽  
Author(s):  
Carsten Teller ◽  
Itamar Willner
Keyword(s):  
Nucleic Acid ◽  
Dna Machines

Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics

2019 ◽  
Vol 11 (15) ◽  
pp. 13912-13920 ◽  
Author(s):  
Hassan H. Fakih ◽  
Johans J. Fakhoury ◽  
Danny Bousmail ◽  
Hanadi F. Sleiman
Keyword(s):  
Nucleic Acid ◽  
Stimuli Responsive ◽  
Spherical Nucleic Acid
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