Intelligent nucleic acid delivery systems based on stimuli-responsive polymers

Soft Matter ◽  
2010 ◽  
Vol 6 (5) ◽  
pp. 835-848 ◽  
Author(s):  
Fu-Sheng Du ◽  
Yang Wang ◽  
Rui Zhang ◽  
Zi-Chen Li
Keyword(s):  
Nucleic Acid ◽  
Delivery Systems ◽  
Nucleic Acid Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

scholarly journals Pluronic® F-127 and Pluronic Lecithin Organogel (PLO): Main Features and their Applications in Topical and Transdermal Administration of Drugs

2012 ◽  
Vol 15 (4) ◽  
pp. 592 ◽  
Author(s):  
Hugo Almeida ◽  
Maria Helena Amaral ◽  
Paulo Lobão ◽  
José Manuel Sousa Lobo
Keyword(s):  
Delivery Systems ◽  
Smart Polymers ◽  
Stimuli Responsive ◽  
Systemic Delivery ◽  
Transdermal Administration ◽  
Polymeric Systems ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Excellent Candidate ◽  
High Concentrations

Topical drug treatment aims at providing high concentrations of drugs at the site of application so as to avoid adverse systemic effects associated with oral administration. Smart polymers, or stimuli-responsive polymers, are able to respond to a stimulus by showing physical or chemical changes in their behaviour as, for example, the delivery of the drug carried by them. The thermo-responsive nature of Pluronic® F-127 (Basf, Ludwigshafen, Germany) makes it an excellent candidate for the delivery of drugs at various application sites. In recent years, PF-127, and later, Pluronic lecithin organogels (PLO), have attracted particular interest in the design of dermal and transdermal delivery systems with a view to promoting, improving or retarding drug permeation through the skin, bearing in mind that for topical delivery systems, accumulation in the skin with minimal permeation is desired, while for systemic delivery, the opposite behaviour is preferred. In this review, we discuss the properties and characteristics of PF-127 and Pluronic lecithin organogels (PLO), and present many examples and advantages of the application of these polymeric systems in topical and transdermal administration of drugs. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

2020 ◽  
Vol 11 (44) ◽  
pp. 6988-7008 ◽  
Author(s):  
Duc Dung Nguyen ◽  
Jui-Yang Lai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Disease Treatment ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Stimuli Response

Recent exploitations of stimuli-responsive polymers as ophthalmic drug delivery systems for the treatment of eye diseases are summarized and discussed.

scholarly journals Classification of stimuli–responsive polymers as anticancer drug delivery systems

Drug Delivery ◽  
2014 ◽  
Vol 22 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Bita Taghizadeh ◽  
Shahrouz Taranejoo ◽  
Seyed Ali Monemian ◽  
Zoha Salehi Moghaddam ◽  
Karim Daliri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

Smart Drug Release Systems Based on Stimuli-Responsive Polymers

2013 ◽  
Vol 13 (9) ◽  
pp. 1369-1380 ◽  
Author(s):  
Guangyan Qing ◽  
Minmin Li ◽  
Lijing Deng ◽  
Ziyu Lv ◽  
Peng Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Smart Drug

scholarly journals Thermo- and Photoresponsive Behaviors of Dual-Stimuli-Responsive Organogels Consisting of Homopolymers of Coumarin-Containing Methacrylate

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 329
Author(s):  
Seidai Okada ◽  
Eriko Sato
Keyword(s):  
Functional Group ◽  
Solution Temperature ◽  
Stimuli Responsive ◽  
Critical Solution Temperature ◽  
Equilibrium Degree ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Dual Functional ◽  
Wide Range ◽  
Increasing Temperature

Coumarin-containing vinyl homopolymers, such as poly(7-methacryloyloxycoumarin) (P1a) and poly(7-(2′-methacryloyloxyethoxy)coumarin) (P1b), show a lower critical solution temperature (LCST) in chloroform, which can be controlled by the [2 + 2] photochemical cycloaddition of the coumarin moiety, and they are recognized as monofunctional dual-stimuli-responsive polymers. A single functional group of monofunctional dual-stimuli-responsive polymers responds to dual stimuli and can be introduced more uniformly and densely than those of dual-functional dual-stimuli-responsive polymers. In this study, considering a wide range of applications, organogels consisting of P1a and P1b, i.e., P1a-gel and P1b-gel, respectively, were synthesized, and their thermo- and photoresponsive behaviors in chloroform were investigated in detail. P1a-gel and P1b-gel in a swollen state (transparent) exhibited phase separation (turbid) through a temperature jump and reached a shrunken state (transparent), i.e., an equilibrium state, over time. Moreover, the equilibrium degree of swelling decreased non-linearly with increasing temperature. Furthermore, different thermoresponsive sites were photopatterned on the organogel through the photodimerization of the coumarin unit. The organogels consisting of homopolymers of coumarin-containing methacrylate exhibited unique thermo- and photoresponsivities and behaved as monofunctional dual-stimuli-responsive organogels.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Polymers

2021 ◽  
Vol 5 (4) ◽  
pp. 101
Author(s):  
Menglian Wei ◽  
Yu Wan ◽  
Xueji Zhang
Keyword(s):  
Metal Organic Framework ◽  
Chemical Properties ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Reversible Phase Transition ◽  
Metal Organic ◽  
External Stimuli ◽  
Organic Framework

Metal-organic framework (MOF) based stimuli-responsive polymers (coordination polymers) exhibit reversible phase-transition behavior and demonstrate attractive properties that are capable of altering physical and/or chemical properties upon exposure to external stimuli, including pH, temperature, ions, etc., in a dynamic fashion. Thus, their conformational change can be imitated by the adsorption/desorption of target analytes (guest molecules), temperature or pressure changes, and electromagnetic field manipulation. MOF-based stimuli responsive polymers have received great attention due to their advanced optical properties and variety of applications. Herein, we summarized some recent progress on MOF-based stimuli-responsive polymers (SRPs) classified by physical and chemical responsiveness, including temperature, pressure, electricity, pH, metal ions, gases, alcohol and multi-targets.

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