Stimuli-Responsive Nucleic Acid-Based Polyacrylamide Hydrogel-Coated Metal-Organic Framework Nanoparticles for Controlled Drug Release

2017 ◽  
Vol 28 (8) ◽  
pp. 1705137 ◽  
Author(s):  
Wei-Hai Chen ◽  
Wei-Ching Liao ◽  
Yang Sung Sohn ◽  
Michael Fadeev ◽  
Alessandro Cecconello ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Drug Release ◽  
Metal Organic Framework ◽  
Controlled Drug Release ◽  
Polyacrylamide Hydrogel ◽  
Stimuli Responsive ◽  
Coated Metal ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Stimuli-responsive nucleic acid-functionalized metal–organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks

2017 ◽  
Vol 8 (8) ◽  
pp. 5769-5780 ◽  
Author(s):  
Wei-Hai Chen ◽  
Xu Yu ◽  
Alessandro Cecconello ◽  
Yang Sung Sohn ◽  
Rachel Nechushtai ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Metal Ion ◽  
Metal Organic Framework ◽  
Stimuli Responsive ◽  
Metal Organic ◽  
Organic Framework

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by pH or Mg2+ ions/ATP triggers, resulting in the release of the loads.

Metal-organic framework nanosheets that exhibit pH-controlled drug release

2017 ◽  
Vol 197 ◽  
pp. 217-220 ◽  
Author(s):  
Xuechuan Gao ◽  
Ruixue Cui ◽  
Ming Zhang ◽  
Zhiliang Liu
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Controlled Drug Release ◽  
Metal Organic ◽  
Ph Controlled ◽  
Organic Framework

A porous metal–organic framework with a unique hendecahedron-shaped cage: structure and controlled drug release

2016 ◽  
Vol 45 (9) ◽  
pp. 3694-3697 ◽  
Author(s):  
Lian-Qiang Wei ◽  
Qing Chen ◽  
Li-Le Tang ◽  
Chong Zhuang ◽  
Wen-Run Zhu ◽  
...  
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Porous Metal ◽  
Controlled Drug Release ◽  
Tricarboxylic Acid ◽  
Good Stability ◽  
Cage Structure ◽  
Acid Ligand ◽  
Metal Organic ◽  
Organic Framework

A porous MOF with [Cu2(COO)4] SBU was constructed from tricarboxylic acid ligand and pyrazine, which features a unique hendecahedron cage-liked cavity with good stability and a high BET surface, showing good controlled drug release properties of ibuprofen over anethole and guaiacol.

A rare (3,4,5)-connected metal–organic framework featuring an unprecedented 1D + 2D → 3D self-interpenetrated array and an O-atom lined pore surface: structure and controlled drug release

2014 ◽  
Vol 50 (99) ◽  
pp. 15807-15810 ◽  
Author(s):  
Di-Chang Zhong ◽  
Lie-Qiang Liao ◽  
Ji-Hua Deng ◽  
Qing Chen ◽  
Ping Lian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Surface Structure ◽  
Metal Organic Framework ◽  
Controlled Drug Release ◽  
Pore Surface ◽  
Metal Organic ◽  
Organic Framework

A rare (3,4,5)-connected metal–organic framework has been constructed, which features an unprecedented 1D + 2D → 3D self-interpenetrated array and an O-atom lined pore surface, and shows good controlled release of ibuprofen.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Polymers

2021 ◽  
Vol 5 (4) ◽  
pp. 101
Author(s):  
Menglian Wei ◽  
Yu Wan ◽  
Xueji Zhang
Keyword(s):  
Metal Organic Framework ◽  
Chemical Properties ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Reversible Phase Transition ◽  
Metal Organic ◽  
External Stimuli ◽  
Organic Framework

Metal-organic framework (MOF) based stimuli-responsive polymers (coordination polymers) exhibit reversible phase-transition behavior and demonstrate attractive properties that are capable of altering physical and/or chemical properties upon exposure to external stimuli, including pH, temperature, ions, etc., in a dynamic fashion. Thus, their conformational change can be imitated by the adsorption/desorption of target analytes (guest molecules), temperature or pressure changes, and electromagnetic field manipulation. MOF-based stimuli responsive polymers have received great attention due to their advanced optical properties and variety of applications. Herein, we summarized some recent progress on MOF-based stimuli-responsive polymers (SRPs) classified by physical and chemical responsiveness, including temperature, pressure, electricity, pH, metal ions, gases, alcohol and multi-targets.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

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