scholarly journals In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Microgels during Spray Drying

2015 ◽  
Vol 7 (7) ◽  
pp. 4202-4215 ◽  
Author(s):  
Weifeng Zhao ◽  
Robertus Wahyu N. Nugroho ◽  
Karin Odelius ◽  
Ulrica Edlund ◽  
Changsheng Zhao ◽  
...  
Keyword(s):  
Spray Drying ◽  
Cross Linking ◽  
Stimuli Responsive

scholarly journals Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2583
Author(s):  
Nina Hartini ◽  
Thangavel Ponrasu ◽  
Jia-Jiuan Wu ◽  
Malinee Sriariyanun ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Antioxidant Activity ◽  
Spray Drying ◽  
Calcium Ions ◽  
Encapsulation Efficiency ◽  
Room Temperature ◽  
Cross Linking ◽  
Inlet Temperature ◽  
Gastrointestinal Fluid

Microencapsulation of curcumin in jelly fig pectin was performed by the vacuum spray drying (VSD) technique. The VSD was advanced with a low inlet temperature of 80–90 °C and low pressure of 0.01 mPa. By the in situ cross-linking with multivalent calcium ions, jelly fig pectin produced stable curcumin encapsulated microparticles. The physiochemical characteristics of microparticles were thoroughly investigated. The results revealed that 0.75 w/w% of jelly fig pectin and inlet temperature of 90 °C could be feasible for obtaining curcumin microparticles. The VSD technique showed the best encapsulation efficiency and yield and loading efficiency was up to 91.56 ± 0.80%, 70.02 ± 1.96%, and 5.45 ± 0.14%, respectively. The curcumin was readily released into simulated gastrointestinal fluid with 95.34 ± 0.78% cumulative release in 24 h. The antioxidant activity was stable after being stored for six months and stored as a solution for seven days at room temperature before analysis. Hence, the VSD technique could be applicable for the microencapsulation of bioactive compounds such as curcumin to protect and use in the food/pharmaceutical industry.

scholarly journals In situ cross-linking of alginate during spray-drying to microencapsulate lipids in powder

2016 ◽  
Vol 58 ◽  
pp. 141-149 ◽  
Author(s):  
Scott A. Strobel ◽  
Herbert B. Scher ◽  
Nitin Nitin ◽  
Tina Jeoh
Keyword(s):  
Spray Drying ◽  
Cross Linking

scholarly journals Controlling swelling and release of hyaluronic acid during aqueous storage by in situ cross-linking during spray drying with alginate

2019 ◽  
Author(s):  
Dana E. Wong ◽  
Julia C. Cunniffe ◽  
Herbert B. Scher ◽  
Tina Jeoh
Keyword(s):  
Hyaluronic Acid ◽  
Spray Drying ◽  
Storage Stability ◽  
Absorption Capacity ◽  
Cross Linking ◽  
Water Absorption Capacity ◽  
Over The Counter ◽  
Aqueous Environments ◽  
Soluble Calcium

AbstractThe success of hyaluronic acid in over-the-counter cosmetics has been limited by its poor storage stability in aqueous environments due to premature swelling and hydrolysis. Here, hyaluronic acid was prepared in dry microparticles, encapsulated by spray-drying in patented in situ calcium cross-linked alginate microcapsules (CLAMs) to minimize swelling and release in aqueous formulations. CLAMs prepared with 61% (d.b.) hyaluronic acid (HA-CLAMs) demonstrated restricted plumping, limited water absorption capacity, and reduced leaching; retaining up to 49 % hyaluronic acid after 2 hrs in water. A new method using chelated soluble calcium resulted in particles with significantly improved hyaluronic acid retention in water. ‘Chelate HA-CLAMs’ exhibited nearly full retention of hyaluronic acid over 2 hr incubation in water, and remained visibly insoluble after 1 year of storage in water at 4°C. Successful hyaluronic acid retention in CLAMs is likely due to the ability of hyaluronic acid to participate in calcium cross-linking.

scholarly journals Interfacial engineering of lithium‐polymer batteries with in situ UV cross‐linking

InfoMat ◽  
2021 ◽  
Author(s):  
Ramin Rojaee ◽  
Samuel Plunkett ◽  
Md Golam Rasul ◽  
Meng Cheng ◽  
Vahid Jabbari ◽  
...  
Keyword(s):  
Cross Linking ◽  
Lithium Polymer Batteries ◽  
Interfacial Engineering

Stabilization of Peptide-Based Vesicles via in situ Oxygen-Mediated Cross-Linking

2012 ◽  
Vol 12 (9) ◽  
pp. 1220-1231 ◽  
Author(s):  
Adrian Sulistio ◽  
Anton Blencowe ◽  
Jiapei Wang ◽  
Gary Bryant ◽  
Xiaoqing Zhang ◽  
...  
Keyword(s):  
Cross Linking

Palladium immobilized on in situ cross-linked chitosan superfine fibers for catalytic application in an aqueous medium

2018 ◽  
Vol 42 (13) ◽  
pp. 11023-11030 ◽  
Author(s):  
Lulu Liang ◽  
Li Nie ◽  
Minjuan Jiang ◽  
Fusheng Bie ◽  
Linjun Shao ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Itaconic Acid ◽  
Cross Linking ◽  
Catalytic Application ◽  
Chitosan Composite

Chitosan composite superfine fibers with a diameter of 321 ± 99 nm were prepared by electrospinning with PEO as the co-spinning polymer and itaconic acid as the in situ cross-linking agent.

Bilayered Antimicrobial Nanofiber Membranes for Wound Dressings via in Situ Cross-Linking Polymerization and Electrospinning

2018 ◽  
Vol 57 (50) ◽  
pp. 17048-17057 ◽  
Author(s):  
Yanping Huang ◽  
Nianhua Dan ◽  
Weihua Dan ◽  
Weifeng Zhao ◽  
Zhongxiang Bai ◽  
...  
Keyword(s):  
Wound Dressings ◽  
Cross Linking ◽  
Nanofiber Membranes

scholarly journals Influence of prolonged formalin fixation of tissue samples on the sensitivity of chromogenic in situ hybridization

2011 ◽  
Vol 23 (6) ◽  
pp. 1212-1216 ◽  
Author(s):  
Meike M. Mostegl ◽  
Barbara Richter ◽  
Nora Dinhopl ◽  
Herbert Weissenböck
Keyword(s):  
In Situ Hybridization ◽  
Nucleic Acid ◽  
Signal Intensity ◽  
Formalin Fixation ◽  
Proteinase K ◽  
Cross Linking ◽  
Fixation Time ◽  
Tissue Samples ◽  
Chromogenic In Situ Hybridization

Chromogenic in situ hybridization (ISH) is a commonly used tool in diagnostic pathology to detect pathogens in formalin-fixed, paraffin-embedded (FFPE) tissue sections. Prolonged formalin fixation time was identified to be a limiting factor for the successful detection of nucleic acid from different pathogens, most probably due to the cross-linking activity of formalin between RNA, DNA, and proteins. Therefore, in the current study, the influence of formalin fixation time on ISH signal intensity of 2 viral ( Porcine circovirus-2 [PCV-2] and Porcine respiratory and reproductive virus [PRRSV]) and 2 protozoal agents ( Cryptosporidium serpentis and Tritrichomonas sp.) was evaluated. Tissue samples were fixed in 7% neutral buffered formaldehyde solution, and at defined intervals, pieces were embedded in paraffin wax and subjected to pathogen-specific ISH. For all 4 pathogens, the signal intensity remained comparable with the starting ISH signal for different periods of fixation (PCV-2: 6 weeks, PRRSV: 23 weeks, C. serpentis: 55 weeks, Tritrichomonas sp.: 53 weeks). Thereafter, the signal started to decline until loss of nucleic acid detection. The influence of increased proteinase K concentrations for inverting the formalin-induced cross-linking activity was examined compared with the standard protocol. With all 4 infectious agents, a 4-fold proteinase K concentration restored the ISH signals to a level comparable with 1 day of fixation. In conclusion, the influence of prolonged formalin fixation on the intensity of detected ISH signal highly depends on the analyzed infectious agent and the pretreatment protocol.

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