scholarly journals Controlling swelling and release of hyaluronic acid during aqueous storage by in situ cross-linking during spray drying with alginate

2019 ◽  
Author(s):  
Dana E. Wong ◽  
Julia C. Cunniffe ◽  
Herbert B. Scher ◽  
Tina Jeoh
Keyword(s):  
Hyaluronic Acid ◽  
Spray Drying ◽  
Storage Stability ◽  
Absorption Capacity ◽  
Cross Linking ◽  
Water Absorption Capacity ◽  
Over The Counter ◽  
Aqueous Environments ◽  
Soluble Calcium

AbstractThe success of hyaluronic acid in over-the-counter cosmetics has been limited by its poor storage stability in aqueous environments due to premature swelling and hydrolysis. Here, hyaluronic acid was prepared in dry microparticles, encapsulated by spray-drying in patented in situ calcium cross-linked alginate microcapsules (CLAMs) to minimize swelling and release in aqueous formulations. CLAMs prepared with 61% (d.b.) hyaluronic acid (HA-CLAMs) demonstrated restricted plumping, limited water absorption capacity, and reduced leaching; retaining up to 49 % hyaluronic acid after 2 hrs in water. A new method using chelated soluble calcium resulted in particles with significantly improved hyaluronic acid retention in water. ‘Chelate HA-CLAMs’ exhibited nearly full retention of hyaluronic acid over 2 hr incubation in water, and remained visibly insoluble after 1 year of storage in water at 4°C. Successful hyaluronic acid retention in CLAMs is likely due to the ability of hyaluronic acid to participate in calcium cross-linking.

The effect of oxidation degree and volume ratio of components on properties and applications of in situ cross-linking hydrogels based on chitosan and hyaluronic acid

2019 ◽  
Vol 103 ◽  
pp. 109670 ◽  
Author(s):  
Nghi Thi-Phuong Nguyen ◽  
Long Vuong-Hoang Nguyen ◽  
Nam Minh-Phuong Tran ◽  
Dat Tan Nguyen ◽  
Tien Ngoc-Thuy Nguyen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Volume Ratio ◽  
Cross Linking ◽  
Oxidation Degree ◽  
Ratio Of Components

Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention

Biomaterials ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 3903-3917 ◽  
Author(s):  
Ling Li ◽  
Ning Wang ◽  
Xun Jin ◽  
Rui Deng ◽  
Shihong Nie ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Adhesion Prevention ◽  
Postoperative Adhesion ◽  
Cross Linking

Novel Hydrogels and Composite Hydrogels Based on ԑ-Polylysine, Hyaluronic Acid and Hydroxyapatite

2020 ◽  
Vol 850 ◽  
pp. 242-248
Author(s):  
Artemijs Ščeglovs ◽  
Kristine Salma-Ancane
Keyword(s):  
Hyaluronic Acid ◽  
Cross Linking ◽  
X Ray ◽  
Composite Hydrogels ◽  
Nanocrystalline Hydroxyapatite ◽  
System Components ◽  
Structure Phase ◽  
Chemical Cross Linking ◽  
Scanning Electron

At this work hydrogel and composite hydrogel systems based on ԑ-polylysine (EPL), hyaluronic acid (HA) and nanocrystalline hydroxyapatite (nHAp) were synthesized via chemical cross-linking method followed by in situ precipitation of nHAp into hydrogel copolymer matrix. Molecular structure, phase composition and morphology of EPL-HA and EPL-HA/nHAp systems were investigated using Fourier transform infrared spectroscopy (FTIR), X-ray powder diffractometry (XRD) and scanning electron microscopy (SEM). The fabricated hydrogels and composite hydrogels were evaluated by hydrogels characteristics such as gel fraction and swelling behavior. This study provides a new insight to develop cutting-edge bioactive hydrogels and composite hydrogels for bone tissue engineering as injectable biomaterials due to beneficial properties of system components.

scholarly journals The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives

Biomaterials ◽  
2007 ◽  
Vol 28 (6) ◽  
pp. 975-983 ◽  
Author(s):  
Taichi Ito ◽  
Yoon Yeo ◽  
Christopher B. Highley ◽  
Evangelia Bellas ◽  
Carlos A. Benitez ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cross Linking ◽  
Cellulose Derivatives ◽  
Peritoneal Adhesions

scholarly journals In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Microgels during Spray Drying

2015 ◽  
Vol 7 (7) ◽  
pp. 4202-4215 ◽  
Author(s):  
Weifeng Zhao ◽  
Robertus Wahyu N. Nugroho ◽  
Karin Odelius ◽  
Ulrica Edlund ◽  
Changsheng Zhao ◽  
...  
Keyword(s):  
Spray Drying ◽  
Cross Linking ◽  
Stimuli Responsive

scholarly journals Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2583
Author(s):  
Nina Hartini ◽  
Thangavel Ponrasu ◽  
Jia-Jiuan Wu ◽  
Malinee Sriariyanun ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Antioxidant Activity ◽  
Spray Drying ◽  
Calcium Ions ◽  
Encapsulation Efficiency ◽  
Room Temperature ◽  
Cross Linking ◽  
Inlet Temperature ◽  
Gastrointestinal Fluid

Microencapsulation of curcumin in jelly fig pectin was performed by the vacuum spray drying (VSD) technique. The VSD was advanced with a low inlet temperature of 80–90 °C and low pressure of 0.01 mPa. By the in situ cross-linking with multivalent calcium ions, jelly fig pectin produced stable curcumin encapsulated microparticles. The physiochemical characteristics of microparticles were thoroughly investigated. The results revealed that 0.75 w/w% of jelly fig pectin and inlet temperature of 90 °C could be feasible for obtaining curcumin microparticles. The VSD technique showed the best encapsulation efficiency and yield and loading efficiency was up to 91.56 ± 0.80%, 70.02 ± 1.96%, and 5.45 ± 0.14%, respectively. The curcumin was readily released into simulated gastrointestinal fluid with 95.34 ± 0.78% cumulative release in 24 h. The antioxidant activity was stable after being stored for six months and stored as a solution for seven days at room temperature before analysis. Hence, the VSD technique could be applicable for the microencapsulation of bioactive compounds such as curcumin to protect and use in the food/pharmaceutical industry.

scholarly journals Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Youming Deng ◽  
Jianan Ren ◽  
Guopu Chen ◽  
Guanwei Li ◽  
Xiuwen Wu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tissue Regeneration ◽  
Cross Linking

scholarly journals In situ cross-linking of alginate during spray-drying to microencapsulate lipids in powder

2016 ◽  
Vol 58 ◽  
pp. 141-149 ◽  
Author(s):  
Scott A. Strobel ◽  
Herbert B. Scher ◽  
Nitin Nitin ◽  
Tina Jeoh
Keyword(s):  
Spray Drying ◽  
Cross Linking
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