scholarly journals Interfacial engineering of lithium‐polymer batteries with in situ UV cross‐linking

InfoMat ◽  
2021 ◽  
Author(s):  
Ramin Rojaee ◽  
Samuel Plunkett ◽  
Md Golam Rasul ◽  
Meng Cheng ◽  
Vahid Jabbari ◽  
...  
Keyword(s):  
Cross Linking ◽  
Lithium Polymer Batteries ◽  
Interfacial Engineering

Stabilization of Peptide-Based Vesicles via in situ Oxygen-Mediated Cross-Linking

2012 ◽  
Vol 12 (9) ◽  
pp. 1220-1231 ◽  
Author(s):  
Adrian Sulistio ◽  
Anton Blencowe ◽  
Jiapei Wang ◽  
Gary Bryant ◽  
Xiaoqing Zhang ◽  
...  
Keyword(s):  
Cross Linking

Palladium immobilized on in situ cross-linked chitosan superfine fibers for catalytic application in an aqueous medium

2018 ◽  
Vol 42 (13) ◽  
pp. 11023-11030 ◽  
Author(s):  
Lulu Liang ◽  
Li Nie ◽  
Minjuan Jiang ◽  
Fusheng Bie ◽  
Linjun Shao ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Itaconic Acid ◽  
Cross Linking ◽  
Catalytic Application ◽  
Chitosan Composite

Chitosan composite superfine fibers with a diameter of 321 ± 99 nm were prepared by electrospinning with PEO as the co-spinning polymer and itaconic acid as the in situ cross-linking agent.

Bilayered Antimicrobial Nanofiber Membranes for Wound Dressings via in Situ Cross-Linking Polymerization and Electrospinning

2018 ◽  
Vol 57 (50) ◽  
pp. 17048-17057 ◽  
Author(s):  
Yanping Huang ◽  
Nianhua Dan ◽  
Weihua Dan ◽  
Weifeng Zhao ◽  
Zhongxiang Bai ◽  
...  
Keyword(s):  
Wound Dressings ◽  
Cross Linking ◽  
Nanofiber Membranes

scholarly journals Influence of prolonged formalin fixation of tissue samples on the sensitivity of chromogenic in situ hybridization

2011 ◽  
Vol 23 (6) ◽  
pp. 1212-1216 ◽  
Author(s):  
Meike M. Mostegl ◽  
Barbara Richter ◽  
Nora Dinhopl ◽  
Herbert Weissenböck
Keyword(s):  
In Situ Hybridization ◽  
Nucleic Acid ◽  
Signal Intensity ◽  
Formalin Fixation ◽  
Proteinase K ◽  
Cross Linking ◽  
Fixation Time ◽  
Tissue Samples ◽  
Chromogenic In Situ Hybridization

Chromogenic in situ hybridization (ISH) is a commonly used tool in diagnostic pathology to detect pathogens in formalin-fixed, paraffin-embedded (FFPE) tissue sections. Prolonged formalin fixation time was identified to be a limiting factor for the successful detection of nucleic acid from different pathogens, most probably due to the cross-linking activity of formalin between RNA, DNA, and proteins. Therefore, in the current study, the influence of formalin fixation time on ISH signal intensity of 2 viral ( Porcine circovirus-2 [PCV-2] and Porcine respiratory and reproductive virus [PRRSV]) and 2 protozoal agents ( Cryptosporidium serpentis and Tritrichomonas sp.) was evaluated. Tissue samples were fixed in 7% neutral buffered formaldehyde solution, and at defined intervals, pieces were embedded in paraffin wax and subjected to pathogen-specific ISH. For all 4 pathogens, the signal intensity remained comparable with the starting ISH signal for different periods of fixation (PCV-2: 6 weeks, PRRSV: 23 weeks, C. serpentis: 55 weeks, Tritrichomonas sp.: 53 weeks). Thereafter, the signal started to decline until loss of nucleic acid detection. The influence of increased proteinase K concentrations for inverting the formalin-induced cross-linking activity was examined compared with the standard protocol. With all 4 infectious agents, a 4-fold proteinase K concentration restored the ISH signals to a level comparable with 1 day of fixation. In conclusion, the influence of prolonged formalin fixation on the intensity of detected ISH signal highly depends on the analyzed infectious agent and the pretreatment protocol.

scholarly journals FORMULATION AND EVALUATION OF DOXORUBICIN CONTAINING NANOGELS FOR DELIVERY TO CANCER CELLS

2018 ◽  
Vol 8 (5) ◽  
pp. 178-183
Author(s):  
Manish Kumar ◽  
Hemant K. Sharma
Keyword(s):  
Average Particle Size ◽  
Gellan Gum ◽  
Cross Linking ◽  
Average Particle ◽  
Scanning Calorimetry ◽  
Green Method ◽  
X Ray ◽  
Oppositely Charged ◽  
Chemical Cross Linking

The objective of this study is to prepare nanogels were prepared via charged gellan gum. It was prepared by in situ cross linking reaction between two oppositely charged materials by green method without use of chemical cross linking agents. The prepared nanogels were characterized by Dynamic light scattering, scanning electron microscopy, differential scanning calorimetry and X- Ray diffractometry. The prepared formulation had average particle size of 226 nm with polydispersity index of 0.3. The doxorubicin loaded nanogel demonstrated sustained release for 20 h. The prepared nanogels were hemocompatible and cyctocompatible as revealed by hemocompatibility and MTT assay respectively. All results confirmed that these nanogels can be used for cancer treatment. Keywords: Nanogel, Chitosan, Gellan gum, Doxorubicin, Cancer.

scholarly journals DESIGN, OPTIMIZATION & IN-VITRO EVALUATION OF SODIUM ALGINATE BASED IN-SITU GEL OF RANITIDINE HYDROCHLORIDE IN ULCER TREATMENT

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Sanket Kumar ◽  
Mahesh Singh ◽  
Babulal Patel
Keyword(s):  
Peptic Ulcer ◽  
Drug Release ◽  
Sodium Alginate ◽  
Gelling Agent ◽  
Cross Linking ◽  
Physical Interaction ◽  
In Situ Gel ◽  
Ranitidine Hydrochloride ◽  
Ulcer Treatment

Peptic ulcer, it is the most common type of stomach disease, according to the American Gastroenterology Association. “We know that ulcers occur because there has been a disruption in the balance of factors that injure the digestive tract and those factors that protect it from injury,” The present investigation deal with the formulation, optimization and evaluation of sodium alginate based in situ gel of ranitidine hydrochloride (R-HCl) in ulcer treatment. The in-situ formulation are homogenous liquid when administration orally and become gel at the contact site. The evaluation of the formulation is dependent upon accurate results obtained by analytical method used during the study. Accurate results require the use of standard and a calibration procedure. Hence, standard plots of Ranitidine hydrochloride were prepared in (0.1N HCL, pH 1.2) solutions. Two, sodium alginate and calcium carbonate used as a polymer and cross-linking agent respectively in the formulation of in-situ gel. From the IR studies it may be concluded that the drug and carriers used undergo physical interaction there is no chemical change, and thus the gelling agent, cross-linking agent and other excipient is suitable for formulation of in-situ gel of ranitidine hydrochloride. Indicate that the formulation, DKF9 which was prepared by the Sodium alginate (2 gm) with Ranitidine Hydrochloride showed minimum drug release (sustained drug release) after 8 hrs. It can be concluded that the In-situ gel was beneficial for delivering the drug which needs sustained release to achieve the slow action. Keywords: In-situ gel, Peptic Ulcer, Ranitidine Hydrochloride (R-HCl), Sodium alginate.

Spray-by-spray in situ cross-linking alginate hydrogels delivering a tea tree oil microemulsion

2015 ◽  
Vol 66 ◽  
pp. 20-28 ◽  
Author(s):  
O. Catanzano ◽  
M.C. Straccia ◽  
A. Miro ◽  
F. Ungaro ◽  
I. Romano ◽  
...  
Keyword(s):  
Cross Linking ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Alginate Hydrogels
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