Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application

2014 ◽  
Vol 6 (21) ◽  
pp. 19327-19335 ◽  
Author(s):  
Qinghui Zeng ◽  
Youlin Zhang ◽  
Wenyu Ji ◽  
Weiguang Ye ◽  
Yinglei Jiang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Silica Shell ◽  
Cellular Toxicity ◽  
Hepatocarcinoma Cell

Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time

2010 ◽  
Vol 4 (1) ◽  
pp. 120-137 ◽  
Author(s):  
Tatsiana Mironava ◽  
Michael Hadjiargyrou ◽  
Marcia Simon ◽  
Vladimir Jurukovski ◽  
Miriam H. Rafailovich
Keyword(s):  
Gold Nanoparticles ◽  
Exposure Time ◽  
Recovery Effect ◽  
Cellular Toxicity

Synthesis of Core@Shell Composites with Gold Nanoparticles Trapped inside Ceramic Silica Shells by the Sol-Gel Method

2008 ◽  
Vol 368-372 ◽  
pp. 797-799 ◽  
Author(s):  
Chien Jung Huang ◽  
Pin Hsiang Chiu ◽  
Yeong Her Wang
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Amorphous Silica ◽  
Plasmon Resonance ◽  
Sol Gel ◽  
Silica Shell ◽  
Core Shell ◽  
Gold Core ◽  
Spherical Gold Nanoparticles

This paper describes a sol-gel (SG) method for the coating of gold nanoparticles with uniform shells of amorphous silica. The thickness of silica could be conveniently controlled in the range of 10 to 120 nm by increasing the amount of water. Although spherical gold nanoparticles generally have a surface plasmon resonance (SPR) at a wavelength of about 520 nm, a spherical gold core with a silica shell offers a very highly tunable SPR wavelength depending on the thickness of the silica shell.

Coating Time Effect on Surface Structures of Silica-Encapsulated Gold Nanoparticles

2009 ◽  
Vol 79-82 ◽  
pp. 935-938
Author(s):  
Qin Qu ◽  
Shan Tang Liu
Keyword(s):  
Gold Nanoparticles ◽  
Optical Properties ◽  
Reaction Time ◽  
Slight Modification ◽  
Silica Shell ◽  
Surface Structures ◽  
Absorption Peak ◽  
Experimental Conditions ◽  
Visible Absorption ◽  
Density Surface

This paper reports the silica density, surface structures and optical properties of gold nanoparticles coated with different thickness of silica shells. The gold nanoparticles encapsulated with amorphous silica shells were prepared in a slight modification of Stǒber method. The silica-shell thickness could be varied from 20 to 50 nm by controlling the experimental conditions, such as reaction time. Transmission Electron Microscopy (TEM) and UV-Visible absorption spectroscopy were employed to characterize the size, shell density, surface structures and the optical properties of these silica-coated gold nanoparticles. The TEM images demonstrated that the density of the silica shell were depended on the reaction time, and the surface morphology was changed from porous structures in the initial coating to the final continuous and smooth silica surface. With the increasing of the reaction time, the silica-coated gold nanoparticles became more and more round and monodispersed. UV-Vis spectra showed that surface plasmon absorption peak had a red-shifted of 3~12 nm on increasing the thickness of silica shell from 20 to 50 nm. A possible mechanism of silica formation on gold nanoparticles was proposed on the basis of silica shell density and the shift of absorption peak of coated gold nanoparticles.

Biodegradable nano-architectures containing gold nanoparticles arrays

MRS Advances ◽  
2016 ◽  
Vol 1 (30) ◽  
pp. 2173-2179
Author(s):  
Domenico Cassano ◽  
Diego Rota Martir ◽  
Giovanni Signore ◽  
Cinzia Avigo ◽  
Luca Menichetti ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Building Blocks ◽  
Silica Shell ◽  
Clinical Translation ◽  
Nanoparticle Assembly ◽  
Gold Nanospheres ◽  
Medical Diagnoses ◽  
Polymer Nanoparticle ◽  
Commercial Polymers

ABSTRACTOne of the major concerns regarding the clinical translation of metal nanoparticles is related to the question of their persistence in organisms that can increase the likelihood of toxicity and the interaction/interference with common medical diagnoses.In order to overcome these issues we have recently introduced a versatile 90 nm nano-architecture composed by: i) arrays of 3 nm gold nanoparticles, ii) functionalizable commercial polymers surrounding the gold nanoparticles, and iii) biodegradable and derivatizable silica shell embedding the polymer-nanoparticle assembly. These robust nanocapsules maintain the intriguing features of gold nanospheres but are biodegraded in physiological media to their potentially renal clearable building blocks.

scholarly journals Gold–silica quantum rattles for multimodal imaging and therapy

2015 ◽  
Vol 112 (7) ◽  
pp. 1959-1964 ◽  
Author(s):  
Mathew Hembury ◽  
Ciro Chiappini ◽  
Sergio Bertazzo ◽  
Tammy L. Kalber ◽  
Glenna L. Drisko ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Drug Carrier ◽  
Material Design ◽  
Tumor Burden ◽  
Silica Shell ◽  
Innovative Material

Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell’s central cavity. This “quantum rattle” structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.

Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells

2013 ◽  
Vol 8 (2) ◽  
pp. 189-201 ◽  
Author(s):  
Tatsiana Mironava ◽  
Michael Hadjiargyrou ◽  
Marcia Simon ◽  
Miriam H. Rafailovich
Keyword(s):  
Gold Nanoparticles ◽  
Stromal Cells ◽  
Cellular Toxicity ◽  
Adipose Derived Stromal Cells

X-Ray Absorption of Gold Nanoparticles with Thin Silica Shell

2006 ◽  
Vol 6 (11) ◽  
pp. 3503-3506 ◽  
Author(s):  
Yeon-Su Park ◽  
Luis M. Liz-Marzán ◽  
Atsuo Kasuya ◽  
Yoshio Kobayashi ◽  
Daisuke Nagao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Silica Shell ◽  
X Ray ◽  
X Ray Absorption
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