Biodegradable nano-architectures containing gold nanoparticles arrays

MRS Advances ◽  
2016 ◽  
Vol 1 (30) ◽  
pp. 2173-2179
Author(s):  
Domenico Cassano ◽  
Diego Rota Martir ◽  
Giovanni Signore ◽  
Cinzia Avigo ◽  
Luca Menichetti ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Building Blocks ◽  
Silica Shell ◽  
Clinical Translation ◽  
Nanoparticle Assembly ◽  
Gold Nanospheres ◽  
Medical Diagnoses ◽  
Polymer Nanoparticle ◽  
Commercial Polymers

ABSTRACTOne of the major concerns regarding the clinical translation of metal nanoparticles is related to the question of their persistence in organisms that can increase the likelihood of toxicity and the interaction/interference with common medical diagnoses.In order to overcome these issues we have recently introduced a versatile 90 nm nano-architecture composed by: i) arrays of 3 nm gold nanoparticles, ii) functionalizable commercial polymers surrounding the gold nanoparticles, and iii) biodegradable and derivatizable silica shell embedding the polymer-nanoparticle assembly. These robust nanocapsules maintain the intriguing features of gold nanospheres but are biodegraded in physiological media to their potentially renal clearable building blocks.

Nanoparticle assembly following Langmuir–Hinshelwood kinetics on a Langmuir film and chain networks captured in LB films

2015 ◽  
Vol 17 (11) ◽  
pp. 7386-7394 ◽  
Author(s):  
Lasya Maganti ◽  
Madhuri Jash ◽  
Anju Nair ◽  
T. P. Radhakrishnan
Keyword(s):  
Metal Nanoparticles ◽  
Nanoparticle Assembly ◽  
Deposition Pressure ◽  
Langmuir Film ◽  
Lb Films ◽  
Langmuir Blodgett ◽  
Langmuir Blodgett Films ◽  
Positively Charged

Negatively charged metal nanoparticles assemble as chain networks through Langmuir–Hinshelwood kinetics on a Langmuir film of positively charged amphiphiles. The extension of the networks captured in Langmuir–Blodgett films is tuned by the deposition pressure.

Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application

2014 ◽  
Vol 6 (21) ◽  
pp. 19327-19335 ◽  
Author(s):  
Qinghui Zeng ◽  
Youlin Zhang ◽  
Wenyu Ji ◽  
Weiguang Ye ◽  
Yinglei Jiang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Silica Shell ◽  
Cellular Toxicity ◽  
Hepatocarcinoma Cell

Hyperthermic Cytotoxicity Induced by Noninvasive Radiofrequency Field Exposure After Delivery of EGFR Family Targeted Gold Nanoparticles

2010 ◽  
Author(s):  
Evan S. Glazer ◽  
Warna D. Kaluarachchi ◽  
Steven A. Curley
Keyword(s):  
Flow Cytometry ◽  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Carcinoma Cells ◽  
Field Exposure ◽  
Radiofrequency Field ◽  
Hep3b Cells ◽  
Egfr Family ◽  
Similar Decrease

Noninvasive radiofrequency (RF) fields heat metal nanoparticles in a concentration dependent fashion. Gold nanoparticles are especially interesting for biomedical applications because they not only heat well, but they have an established biosafety profile. Antibody-targeted gold nanoparticles have been used to induce hyperthermic cytotoxicity when exposed to RF fields. Two carcinoma cells lines, Panc-1 and Hep3B, were individually treated with 100 nM panitumumab and trastuzumab antibody conjugated 10 nm gold nanoparticles and subsequently exposed to an RF field for a total generator power of ∼100 kJ. Two days later, control cells treated with antibody labeled gold nanoparticles, but not exposed to the RF field, maintained an average viability of 92.1% ± 2.5% for Hep 3B cells and 89.1% ± 2.1% for Panc-1 cells based on flow cytometry. Panc-1 cells treated the same way with subsequent RF field exposure had viability less than 80% (p ∼ 0.001). Hep3B cells showed a similar decrease in viability after trastuzumab-gold treatment (74.5% ± 6.9%), but not panitumumab. This demonstrates a new and developing use of antibodies, specifically, against EGFR family targets.

scholarly journals Green ultrasonic synthesis, Characterization and Antibacterial activity of Silver and Gold Nanoparticles mediated by Ganoderma lucidum extract

2020 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Gold Nanoparticles ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Metal Nanoparticles ◽  
Cytotoxic Activities ◽  
Gold And Silver Nanoparticles ◽  
Silver And Gold Nanoparticles ◽  
E Coli ◽  
Inhibition Zones

Metal nanoparticles possess an extensive scientific and technological significance due to their unique physiochemical properties and their potential applications in different fields like medicine. Silver and gold nanoparticles have shown to have antibacterial and cytotoxic activities. Conventional methods used in the synthesis of the metal nanoparticles involve use of toxic chemicals making them unsuitable for use in medical field. In our continued effort to explore for simple and eco-friendly methods to synthesize the metal nanoparticles, we here describe synthesis and characterization of gold and silver nanoparticles using Gonaderma lucidum, wild non-edible medicinal mushroom. G. lucidum mushroom contain bioactive compounds which can be involved in the reduction, capping and stabilization of the nanoparticles. Antibacterial activity analysis was done on E. coli and S. aureus. The synthesis was done on ultrasonic bath. Characterization of the metal nanoparticles was done by UV-VIS., High Resolution Transmission Electron Microscope (HRTEM) and FTIR. HRTEM analysis showed that both silver and gold nanoparticles were spherical in shape with an average size of 15.82±3.69 nm for silver and 24.73±5.124nm for gold nanoparticles (AuNPs). FTIR analysis showed OH and -C=C- stretching vibrations, an indication of presence of functional groups of biomolecules capping both gold and silver nanoparticles. AgNPs showed inhibition zones of 15.5±0.09mm and 13.3±0.14mm while AuNPs had inhibition zones of 14.510±0.35 and 13.3±0.50mm on E. coli and S. aureus respectively. The findings indicate the potential use of AgNPs and AuNPs in development of drugs in management of pathogenic bacteria.

scholarly journals Hemoglobin-driven iron-directed assembly of gold nanoparticles

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15675-15686 ◽  
Author(s):  
Jacquelyn G. Egan ◽  
Nicole Drossis ◽  
Iraklii I. Ebralidze ◽  
Holly M. Fruehwald ◽  
Nadia O. Laschuk ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Directed Assembly ◽  
Building Blocks ◽  
Form Complex

The ability to form complex 3D architectures using nanoparticles as the building blocks and complex macromolecules that direct these assemblies remains a challenging objective for nanotechnology.

Investigation of the Shape Effects of Green Synthesized Gold Nanoparticles on Electrochemical Detection of Dopamine

2020 ◽  
Vol 64 ◽  
pp. 105-114
Author(s):  
Abdurrahman Taha Gülderen ◽  
Yasemin Oztekin
Keyword(s):  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Electrochemical Detection ◽  
Pomegranate Juice ◽  
Dopamine Oxidation ◽  
Shape Effects ◽  
Nanoparticle Shapes

Herein, this study shows three different synthesis of gold nanoparticles with various nano-shapes and an investigation of the correlation between nano-shapes and electrochemical effects on dopamine oxidation. To synthesize nano-shaped gold nanoparticles green reducing sources such as rose extract, glucose, and pomegranate juice were used. Thereby, three different gold nanoparticles were synthesized. In order to examine nanoparticle shapes microscopic and spectroscopic characterizations of nanoparticles were carried out. Subsequently the effects of shapes on electrochemical probes and dopamine were accomplished. As a result, it was confirmed that the shapes of the same metal nanoparticles had different effects on electrochemical experiments.

scholarly journals Collective excitation of plasmon-coupled Au-nanochain boosts photocatalytic hydrogen evolution of semiconductor

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Guiyang Yu ◽  
Jun Qian ◽  
Peng Zhang ◽  
Bo Zhang ◽  
Wenxiang Zhang ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Metal Nanoparticles ◽  
Hydrogen Evolution ◽  
Rational Design ◽  
Collective Excitation ◽  
Formation Rate ◽  
Building Blocks ◽  
Localized Surface Plasmon ◽  
Plasmonic Enhancement ◽  
Photocatalytic Hydrogen Evolution

Abstract Localized surface plasmon resonance (LSPR) offers a valuable opportunity to improve the efficiency of photocatalysts. However, plasmonic enhancement of photoconversion is still limited, as most of metal-semiconductor building blocks depend on LSPR contribution of isolated metal nanoparticles. In this contribution, the concept of collective excitation of embedded metal nanoparticles is demonstrated as an effective strategy to enhance the utilization of plasmonic energy. The contribution of Au-nanochain to the enhancement of photoconversion is 3.5 times increase in comparison with that of conventional isolated Au nanoparticles. Experimental characterization and theoretical simulation show that strongly coupled plasmonic nanostructure of Au-nanochain give rise to highly intensive electromagnetic field. The enhanced strength of electromagnetic field essentially boosts the formation rate of electron-hole pair in semiconductor, and ultimately improves photocatalytic hydrogen evolution activity of semiconductor photocatalysts. The concept of embedded coupled-metal nanostructure represents a promising strategy for the rational design of high-performance photocatalysts.

Surface Plasmon Coupling in Dimers of Gold Nanoparticles: Experiment and Theory for Ideal (Spherical) and Nonideal (Faceted) Building Blocks

ACS Photonics ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 642-648 ◽  
Author(s):  
Jun Hee Yoon ◽  
Florian Selbach ◽  
Ludmilla Schumacher ◽  
Jesil Jose ◽  
Sebastian Schlücker
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon ◽  
Building Blocks ◽  
Plasmon Coupling ◽  
Surface Plasmon Coupling

scholarly journals Multivalent Lactose–Ferrocene Conjugates Based on Poly (Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 203 ◽  
Author(s):  
Manuel C. Martos-Maldonado ◽  
Indalecio Quesada-Soriano ◽  
Luis García-Fuentes ◽  
Antonio Vargas-Berenguel
Keyword(s):  
Gold Nanoparticles ◽  
Surface Modification ◽  
Cardiac Remodeling ◽  
Building Blocks ◽  
Differential Pulse ◽  
Pamam Dendrimers ◽  
Titration Calorimetry ◽  
Vis Spectroscopy ◽  
Galectin 3 ◽  
Pulse Voltammetry

Galectin-3 is considered a cancer biomarker and bioindicator of fibrosis and cardiac remodeling and, therefore, it is desirable to develop convenient methods for its detection. Herein, an approach based on the development of multivalent electrochemical probes with high galectin-3 sensing abilities is reported. The probes consist of multivalent presentations of lactose–ferrocene conjugates scaffolded on poly (amido amine) (PAMAM) dendrimers and gold nanoparticles. Such multivalent lactose–ferrocene conjugates are synthesized by coupling of azidomethyl ferrocene–lactose building blocks on alkyne-functionalized PAMAM, for the case of the glycodendrimers, and to disulfide-functionalized linkers that are then used for the surface modification of citrate-stabilized gold nanoparticles. The binding and sensing abilities toward galectin-3 of both ferrocene-containing lactose dendrimers and gold nanoparticles have been evaluated by means of isothermal titration calorimetry, UV–vis spectroscopy, and differential pulse voltammetry. The highest sensitivity by electrochemical methods to galectin-3 was shown by lactosylferrocenylated gold nanoparticles, which are able to detect the lectin in nanomolar concentrations.

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