High Cell Selectivity and Low-Level Antibacterial Resistance of Designed Amphiphilic Peptide G(IIKK)3I-NH2

Cuixia Chen; Jing Hu; Ping Zeng; Yucan Chen; Hai Xu; Jian R. Lu

doi:10.1021/am504973d

High Cell Selectivity and Low-Level Antibacterial Resistance of Designed Amphiphilic Peptide G(IIKK)3I-NH2

ACS Applied Materials & Interfaces ◽

10.1021/am504973d ◽

2014 ◽

Vol 6 (19) ◽

pp. 16529-16536 ◽

Cited By ~ 35

Author(s):

Cuixia Chen ◽

Jing Hu ◽

Ping Zeng ◽

Yucan Chen ◽

Hai Xu ◽

...

Keyword(s):

Antibacterial Resistance ◽

High Cell ◽

Low Level ◽

Cell Selectivity ◽

Amphiphilic Peptide ◽

Peptide G

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Low-level antibacterial resistance: a gateway to clinical resistance

Drug Resistance Updates ◽

10.1054/drup.2001.0196 ◽

2001 ◽

Vol 4 (2) ◽

pp. 93-105 ◽

Cited By ~ 115

Author(s):

Fernando Baquero

Keyword(s):

Antibacterial Resistance ◽

Low Level ◽

Clinical Resistance

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Antitumor properties of platinum(iv) prodrug-loaded silk fibroin nanoparticles

Dalton Transactions ◽

10.1039/c5dt00378d ◽

2015 ◽

Vol 44 (30) ◽

pp. 13513-13521 ◽

Cited By ~ 23

Author(s):

A. Abel Lozano-Pérez ◽

Ana L. Gil ◽

Sergio A. Pérez ◽

Natalia Cutillas ◽

Hajo Meyer ◽

...

Keyword(s):

Silk Fibroin ◽

High Cell ◽

Cell Selectivity ◽

Silk Fibroin Nanoparticles ◽

Antitumor Properties

We have successfully generated silk nanoparticles loaded with the hydrophobic platinum(iv) antitumor prodrug PtBz achieving high cell selectivity factors.

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Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity

Biotechnology and Applied Biochemistry ◽

10.1002/bab.1456 ◽

2015 ◽

Vol 64 (1) ◽

pp. 35-42 ◽

Cited By ~ 14

Author(s):

Pavel V. Panteleev ◽

Tatiana V. Ovchinnikova

Keyword(s):

Antimicrobial Peptide ◽

High Cell ◽

Recombinant Production ◽

Cell Selectivity ◽

Tachyplesin I

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Tryptophan-Niacin Metabolism in Rat with Puromycin Aminonucleoside-Induced Nephrosis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.76.1.28 ◽

2006 ◽

Vol 76 (1) ◽

pp. 28-33 ◽

Cited By ~ 7

Author(s):

Yukari Egashira ◽

Shin Nagaki ◽

Hiroo Sanada

Keyword(s):

Body Weight ◽

Urinary Excretion ◽

Enzyme Activities ◽

Treated Group ◽

Control Group ◽

Puromycin Aminonucleoside ◽

Low Level ◽

Key Enzyme

We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan-niacin conversion. PAN-treated rats were intraperitoneally injected once with a 1.0% (w/v) solution of PAN at a dose of 100 mg/kg body weight. The collection of 24-hour urine was conducted 8 days after PAN injection. Daily urinary excretion of nicotinamide and its metabolites, liver and blood NAD, and key enzyme activities of tryptophan-niacin metabolism were determined. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. The kidneyα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) activity in the PAN-treated group was significantly decreased by 50%, compared with the control group. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. A decrease in urinary excretion of niacin and the conversion of tryptophan to niacin in nephrotic rats may contribute to a low level of blood tryptophan. The role of kidney ACMSD activity may be minimal concerning tryptophan-niacin conversion under this experimental condition.

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