Polyphosphoester-Based Nanoparticles with Viscous Flow Core Enhanced Therapeutic Efficacy by Improved Intracellular Drug Release

2014 ◽  
Vol 6 (18) ◽  
pp. 16174-16181 ◽  
Author(s):  
Yin-Chu Ma ◽  
Jun-Xia Wang ◽  
Wei Tao ◽  
Hai-Sheng Qian ◽  
Xian-Zhu Yang
Keyword(s):  
Drug Release ◽  
Viscous Flow ◽  
Therapeutic Efficacy ◽  
Flow Core

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Synergistic antitumor efficacy of hybrid micelles with mitochondrial targeting and stimuli-responsive drug release behavior

2019 ◽  
Vol 7 (9) ◽  
pp. 1415-1426 ◽  
Author(s):  
Zhoujiang Chen ◽  
Zhanlin Zhang ◽  
Maohua Chen ◽  
Songzhi Xie ◽  
Tao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Therapeutic Efficacy ◽  
Antitumor Efficacy ◽  
Release Behavior ◽  
Stimuli Responsive ◽  
Mitochondrial Targeting ◽  
Drug Release Behavior ◽  
Therapeutic Benefits

The term synergism means that the overall therapeutic benefits should be greater than the sum of the effects of individual agents and that the optimal therapeutic efficacy can be achieved at reduced doses.

Albumin enhances PTX delivery ability of dextran NPs and therapeutic efficacy of PTX for colorectal cancer

2019 ◽  
Vol 7 (22) ◽  
pp. 3537-3545 ◽  
Author(s):  
Xinyu Zhang ◽  
Ruhe Zhang ◽  
Jun Huang ◽  
Moucheng Luo ◽  
Xuewen Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Ph Responsive

The nanoassemblies of Dex6k–BSA–PTX and the pH-responsive drug release for anti-tumor applications in vivo.

Photocleavable Core Cross-Linked Polymeric Micelles of Polypept(o)ides and Ruthenium(II) Complexes

2021 ◽  
Author(s):  
Tobias A. Bauer ◽  
Jonas Eckrich ◽  
Nadine Wiesmann ◽  
Felix Kuczelinis ◽  
Wen Sun ◽  
...  
Keyword(s):  
Drug Release ◽  
Spatial Resolution ◽  
Therapeutic Efficacy ◽  
Polymeric Micelles ◽  
Cross Linking ◽  
On Demand ◽  
Enhanced Stability

Core cross-linking of polymeric micelles has been demonstrated to contribute to enhanced stability that can improve therapeutic efficacy. Photochemistry has the potential to provide spatial resolution and on-demand drug release....

NIR-Activated Supersensitive Drug Release Using Nanoparticles with a Flow Core

2016 ◽  
Vol 26 (41) ◽  
pp. 7516-7525 ◽  
Author(s):  
Junxia Wang ◽  
Yang Liu ◽  
Yinchu Ma ◽  
Chunyang Sun ◽  
Wei Tao ◽  
...  
Keyword(s):  
Drug Release ◽  
Flow Core

A Dual-FRET-Based Versatile Prodrug for Real-Time Drug Release Monitoring and In Situ Therapeutic Efficacy Evaluation

2015 ◽  
Vol 25 (47) ◽  
pp. 7317-7326 ◽  
Author(s):  
Shi-Ying Li ◽  
Li-Han Liu ◽  
Lei Rong ◽  
Wen-Xiu Qiu ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Therapeutic Efficacy ◽  
Efficacy Evaluation

scholarly journals Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery

2021 ◽  
Vol 11 (20) ◽  
pp. 9541
Author(s):  
Zhichu Xiang ◽  
Mouquan Liu ◽  
Jun Song
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Normal Tissue ◽  
Controlled Drug Delivery ◽  
Polymeric Materials ◽  
Stimuli Responsive ◽  
Antitumor Therapy ◽  
Drug Delivery Applications ◽  
External Stimuli

Biocompatible nanosystems based on polymeric materials are promising drug delivery nanocarrier candidates for antitumor therapy. However, the efficacy is unsatisfying due to nonspecific accumulation and drug release of the nanoparticles in normal tissue. Recently, the nanosystems that can be triggered by tumor-specific stimuli have drawn great interest for drug delivery applications due to their controllable drug release properties. In this review, various polymers and external stimuli that can be employed to develop stimuli-responsive polymeric nanosystems are discussed, and finally, we delineate the challenges in designing this kind of Nanomedicine to improve the therapeutic efficacy.

Retracted Article: Creation of ultrasound and temperature-triggered bubble liposomes from economical precursors to enhance the therapeutic efficacy of curcumin in cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85473-85485 ◽  
Author(s):  
Santanu Patra ◽  
Ekta Roy ◽  
Rashmi Madhuri ◽  
Prashant K. Sharma
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Release Profile ◽  
Drug Release Profile ◽  
Temperature Responsive ◽  
Retracted Article

An ultrasound and temperature responsive bubble liposome has been designed with high physiological stability, targeted, rapid and tunable drug release profile.

Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery

2020 ◽  
Vol 27 (23) ◽  
pp. 3877-3887
Author(s):  
Xinyu He ◽  
Xianzhu Yang ◽  
Dongdong Li ◽  
Ziyang Cao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Uptake ◽  
Design Strategies ◽  
Polymeric Nanocarriers ◽  
Normal Tissues ◽  
On Demand ◽  
Nir Light

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.

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