Synergistic antitumor efficacy of hybrid micelles with mitochondrial targeting and stimuli-responsive drug release behavior

2019 ◽  
Vol 7 (9) ◽  
pp. 1415-1426 ◽  
Author(s):  
Zhoujiang Chen ◽  
Zhanlin Zhang ◽  
Maohua Chen ◽  
Songzhi Xie ◽  
Tao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Therapeutic Efficacy ◽  
Antitumor Efficacy ◽  
Release Behavior ◽  
Stimuli Responsive ◽  
Mitochondrial Targeting ◽  
Drug Release Behavior ◽  
Therapeutic Benefits

The term synergism means that the overall therapeutic benefits should be greater than the sum of the effects of individual agents and that the optimal therapeutic efficacy can be achieved at reduced doses.

scholarly journals Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2591
Author(s):  
Thuan Thi Duong ◽  
Antti Isomäki ◽  
Urve Paaver ◽  
Ivo Laidmäe ◽  
Arvo Tõnisoo ◽  
...  
Keyword(s):  
Thin Film ◽  
Drug Release ◽  
Size Distribution ◽  
Water Soluble ◽  
Release Behavior ◽  
Uniform Size ◽  
Ethanol Injection ◽  
Drug Release Behavior ◽  
Poorly Water Soluble

Berberine (BBR) is a poorly water-soluble quaternary isoquinoline alkaloid of plant origin with potential uses in the drug therapy of hypercholesterolemia. To tackle the limitations associated with the oral therapeutic use of BBR (such as a first-pass metabolism and poor absorption), BBR-loaded liposomes were fabricated by ethanol-injection and thin-film hydration methods. The size and size distribution, polydispersity index (PDI), solid-state properties, entrapment efficiency (EE) and in vitro drug release of liposomes were investigated. The BBR-loaded liposomes prepared by ethanol-injection and thin-film hydration methods presented an average liposome size ranging from 50 nm to 244 nm and from 111 nm to 449 nm, respectively. The PDI values for the liposomes were less than 0.3, suggesting a narrow size distribution. The EE of liposomes ranged from 56% to 92%. Poorly water-soluble BBR was found to accumulate in the bi-layered phospholipid membrane of the liposomes prepared by the thin-film hydration method. The BBR-loaded liposomes generated by both nanofabrication methods presented extended drug release behavior in vitro. In conclusion, both ethanol-injection and thin-film hydration nanofabrication methods are feasible for generating BBR-loaded oral liposomes with a uniform size, high EE and modified drug release behavior in vitro.

In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76237-76245 ◽  
Author(s):  
M. Sun ◽  
M. Chen ◽  
M. Wang ◽  
J. Hansen ◽  
A. Baatrup ◽  
...  
Keyword(s):  
Clinical Study ◽  
Drug Release ◽  
Bone Formation ◽  
Chemotherapeutic Agent ◽  
Dual Function ◽  
Release Behavior ◽  
Drug Release Behavior

This pre-clinical study presented a dual function of a doxorubicin-loaded scaffold for both chemotherapeutic agent delivery and bone formation.

Nano-Surface Modification on Titanium Implants for Drug Delivery

2007 ◽  
Vol 1054 ◽  
Author(s):  
Chang Yao ◽  
Thomas J Webster
Keyword(s):  
Drug Release ◽  
Surface Engineering ◽  
Physical Adsorption ◽  
Titanium Implants ◽  
Orthopedic Implant ◽  
Release Behavior ◽  
Oh Groups ◽  
Chemically Modified ◽  
Drug Release Behavior

ABSTRACTThe surface layer of titanium implants, i.e. titanium dioxide, is responsible for the inertness of titanium-based implants within the human body. However, their cytocompatibility properties and long-term efficacy are limited without further surface engineering since the average functional lifetime of an orthopedic implant is only 10 to 15 years. In this study, an electrochemical method known as anodization was used to create titania nanotubular structures on titanium implant surfaces. These nanotubes were about 60 nm wide (inner diameter) and 200 nm deep. In vitro studies found that anodized surfaces consisting of titania nanotube arrays were favored by bone-forming cells (osteoblasts) compared to unanodized surfaces. These titania nano-tubular structures were utilized here as novel drug release delivery systems. It is proposed that the system designed here can have multi-functional drug release to inhibit infection and wound inflammation while increasing new bone formation. For this purpose, antibiotic drugs (penicillin and streptomycin) were loaded into these nanotubular structures by physical adsorption. To mediate interactions between drug molecules and nanotube walls, anodized titanium nanotubes were modified by silanization to possess amine or methyl groups on their surface instead of −OH groups. Results showed increased hydrophobicity of chemically modified titania nanotubes (methyl > amine > hydroxyl terminated surface). These drug loaded substrates were soaked in phosphate buffered solution in a simulated body environment to determine drug release behavior. Buffer solutions were collected and replaced every day. The eluted drug amounts were measured spectroscopically. Results showed more antibiotic penicillin and streptomycin released from chemically modified nanotubes compared to unanodized titanium substrates; specifically, titania anodized nanotubes functionalized with −OH groups did quite well. In this manner, this study advances titanium currently used in orthopedics to possess drug release behavior which can improve orthopedic implant efficacy.

scholarly journals Drug release behavior of polymeric matrix filled in capsule

2016 ◽  
Vol 24 (6) ◽  
pp. 627-634 ◽  
Author(s):  
Thawatchai Phaechamud ◽  
Wanwilai Darunkaisorn
Keyword(s):  
Drug Release ◽  
Polymeric Matrix ◽  
Release Behavior ◽  
Drug Release Behavior

Cholesterol succinyl chitosan anchored liposomes: preparation, characterization, physical stability, and drug release behavior

2010 ◽  
Vol 6 (3) ◽  
pp. 471-477 ◽  
Author(s):  
Yinsong Wang ◽  
Shaoli Tu ◽  
Rongshan Li ◽  
XiaoYing Yang ◽  
Lingrong Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Physical Stability ◽  
Release Behavior ◽  
Drug Release Behavior

scholarly journals Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yixiang Shi ◽  
Ajun Wan ◽  
Yifei Shi ◽  
Yueyue Zhang ◽  
Yupeng Chen
Keyword(s):  
Drug Release ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Solid Material ◽  
Loading Capacity ◽  
Simulation Studies ◽  
Release Behavior ◽  
Molecular Weights ◽  
Drug Release Behavior ◽  
Positively Charged

The study of drug release dynamic is aiming at understanding the process that drugs release in human body and its dynamic characteristics. It is of great significance since these characteristics are closely related to the dose, dosage form, and effect of the drugs. The Noyes-Whitney function is used to represent how the solid material is dissolved into solution, and it is well used in study of drug dynamic. In this research, aspirin (acetylsalicylic acid (ASA)) has been encapsulated with different grades of chitosan (CS) varying in molecular weight (Mw) for the purpose of controlled release. The encapsulation was accomplished by ionic gelation technology based on assembly of positively charged chitosan and negatively charged sodium tripolyphosphate (TPP). The encapsulation efficiency, loading capacity, and drug release behavior of aspirin loaded chitosan nanoparticles (CS-NPs) were studied. It was found that the concentration of TPP and Aspirin, molecular weights of chitosan have important effect on the drug release patterns from chitosan nanoparticles. The results for simulation studies show that the Noyes-Whitney equation can be successfully used to interpret the drug release characteristics reflected by our experimental data.

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