Drug Release from pH-Sensitive Polymeric Micelles with Different Drug Distributions: Insight from Coarse-Grained Simulations

2014 ◽  
Vol 6 (20) ◽  
pp. 17668-17678 ◽  
Author(s):  
Shu Yu Nie ◽  
Wen Jing Lin ◽  
Na Yao ◽  
Xin Dong Guo ◽  
Li Juan Zhang
Keyword(s):  
Drug Release ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Coarse Grained ◽  
Coarse Grained Simulations

A photoacoustic approach for monitoring the drug release of pH-sensitive poly(β-amino ester)s

2014 ◽  
Vol 2 (37) ◽  
pp. 6271-6282 ◽  
Author(s):  
Zhongyu Duan ◽  
Yu-Juan Gao ◽  
Zeng-Ying Qiao ◽  
Gang Fan ◽  
Ya Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymeric Micelles ◽  
Graft Copolymers ◽  
Ph Sensitive ◽  
Photoacoustic Tomography ◽  
Hydrophobic Core ◽  
Amino Ester ◽  
Release Profiles

In this work, we prepared PEG modified poly(β-amino ester) graft copolymers with pH-sensitive properties. Doxorubicin (DOX) and squaraine (SQ) dye as a photoacoustic tomography (PAT) reporter molecule were loaded into the hydrophobic core of polymeric micelles, and their release profiles investigated using the PAT technique.

scholarly journals Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11026-11037 ◽  
Author(s):  
Yang Chen ◽  
Cejun Yang ◽  
Juan Mao ◽  
Haigang Li ◽  
Jinsong Ding ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Antitumor Therapy ◽  
Anti Cancer ◽  
Targeting Delivery

Tumor targeting delivery of SPM functionalized micelles via PTS binding and their endocytosis and pH-triggered endo/lysosome drug release for anti-cancer therapy.

Grand-Reaction Method for Simulations of Ionization Equilibria and Ion Partitioning in a Broad Range of pH and Ionic Strength

2019 ◽  
Author(s):  
Jonas Landsgesell ◽  
Oleg Rud ◽  
Pascal Hebbeker ◽  
Raju Lunkad ◽  
Peter Košovan ◽  
...  
Keyword(s):  
Mean Field ◽  
Coarse Grained ◽  
Reactive System ◽  
Acid Base ◽  
Buffer Solution ◽  
Reaction Method ◽  
Ionization Equilibria ◽  
Coarse Grained Simulations ◽  
Ph Range ◽  
Weak Polyelectrolytes

We introduce the grand-reaction method for coarse-grained simulations of acid-base equilibria in a system coupled to a reservoir at a given pH and concentration of added salt. It can be viewed as an extension of the constant-pH method and the reaction ensemble, combining explicit simulations of reactions within the system, and grand-canonical exchange of particles with the reservoir. Unlike the previously introduced methods, the grand-reaction method is applicable to acid-base equilibria in the whole pH range because it avoids known artifacts. However, the method is more general, and can be used for simulations of any reactive system coupled to a reservoir of a known composition. To demonstrate the advantages of the grand-reaction method, we simulated a model system: A solution of weak polyelectrolytes in equilibrium with a buffer solution. By carefully accounting for the exchange of all constituents, the method ensures that all chemical potentials are equal in the system and in the multi-component reservoir. Thus, the grand-reaction method is able to predict non-monotonic swelling of weak polyelectrolytes as a function of pH, that has been known from mean-field predictions and from experiments but has never been observed in coarse-grained simulations. Finally, we outline possible extensions and further generalizations of the method, and provide a set of guidelines to enable safe usage of the method by a broad community of users.<br><br>

Polymeric micelles using cholinium-based ionic liquids for the encapsulation and drug release of hydrophobic molecules

2021 ◽  
Author(s):  
Isabelle Kurnik ◽  
Natália D’Angelo ◽  
Priscila Gava Mazzola ◽  
Marlus Chorilli ◽  
Daniel Kamei ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Drug Release ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymer ◽  
Two Phase ◽  
Temperature Responsive ◽  
Micellar Systems

We generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The...

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