Polymeric micelles using cholinium-based ionic liquids for the encapsulation and drug release of hydrophobic molecules

2021 ◽  
Author(s):  
Isabelle Kurnik ◽  
Natália D’Angelo ◽  
Priscila Gava Mazzola ◽  
Marlus Chorilli ◽  
Daniel Kamei ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Drug Release ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymer ◽  
Two Phase ◽  
Temperature Responsive ◽  
Micellar Systems

We generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The...

scholarly journals Separation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids

2020 ◽  
Vol 250 ◽  
pp. 117262 ◽  
Author(s):  
Isabelle S. Kurnik ◽  
Mariana A. Noronha ◽  
Mayra C.C. Câmara ◽  
Priscila G. Mazzola ◽  
António A. Vicente ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Amphiphilic Copolymer ◽  
Separation And Purification ◽  
Two Phase ◽  
Micellar Systems

Molecular design of biodegradable polymeric micelles for temperature-responsive drug release

2006 ◽  
Vol 115 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Masamichi Nakayama ◽  
Teruo Okano ◽  
Takanari Miyazaki ◽  
Fukashi Kohori ◽  
Kiyotaka Sakai ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymeric Micelles ◽  
Molecular Design ◽  
Temperature Responsive

Using coarse-grained molecular dynamics to understand the effect of ionic liquids on the aggregation of Pluronic copolymer solutions

2021 ◽  
Author(s):  
German Perez-Sanchez ◽  
Nicolas Schaeffer ◽  
André Lopes ◽  
Jorge F B Pereira ◽  
Joao A. P. Coutinho
Keyword(s):  
Molecular Dynamics ◽  
Ionic Liquids ◽  
Triblock Copolymers ◽  
Selective Separation ◽  
Coarse Grained ◽  
Two Phase ◽  
Micellar Systems ◽  
Coarse Grained Molecular Dynamics

This study is aimed to enhance the understanding of the interaction between ionic liquids (ILs) and non-ionic Pluronic triblock copolymers in aqueous two-phase micellar systems (ATPMS) used for selective separation/purification...

scholarly journals Drug release from thin films encapsulated by a temperature-responsive hydrogel

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1853-1859 ◽  
Author(s):  
Oliver Werzer ◽  
Stephan Tumphart ◽  
Roman Keimel ◽  
Paul Christian ◽  
Anna Maria Coclite
Keyword(s):  
Thin Films ◽  
Controlled Release ◽  
Drug Release ◽  
Temperature Responsive ◽  
Temperature Controlled ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

Temperature-controlled release and study on the effects of the drug–polymer interaction and pH.

A two-phase system for the clean and high yield synthesis of furylmethane derivatives over –SO3H functionalized ionic liquids

2017 ◽  
Vol 19 (20) ◽  
pp. 4804-4810 ◽  
Author(s):  
S. H. Shinde ◽  
C. V. Rode
Keyword(s):  
Ionic Liquids ◽  
Reaction System ◽  
High Yield ◽  
Phase System ◽  
Phase Reaction ◽  
Two Phase ◽  
Yield Production ◽  
High Yield Production

A new and effective unique two-phase reaction system for the high yield production of tri(furyl)methane from furfural and furan.

Drug release behaviors of a novel pH/temperature-responsive chitosan-poly(N-acryloylglycinate) hydrogel

2011 ◽  
Vol 120 (6) ◽  
pp. 3297-3303 ◽  
Author(s):  
Kuilin Deng ◽  
Lirong Dong ◽  
Qian Li ◽  
Yubo Gou ◽  
Pengfei Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Temperature Responsive

scholarly journals Novel polymeric micelles for insect pest control: encapsulation of essential oil monoterpenes inside a triblock copolymer shell for head lice control

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3171 ◽  
Author(s):  
Alejandro Lucia ◽  
Ariel Ceferino Toloza ◽  
Eduardo Guzmán ◽  
Francisco Ortega ◽  
Ramón G. Rubio
Keyword(s):  
Essential Oil ◽  
Pest Control ◽  
Polymeric Micelles ◽  
Ex Vivo ◽  
Insect Pest ◽  
Immersion Test ◽  
Poloxamer 407 ◽  
Head Lice ◽  
Hydrophobic Core ◽  
Micellar Systems

BackgroundEssential oil components (EOCs) are molecules with interesting application in pest control, these have been evaluated against different insect pest from more than 100 years, but their practical use is rather limited. Thus, the enhancement of their bioavailability and manageability due to their dispersion in water can open new perspective for the preparation of formulations for the control of insect pest. In this work, we studied the encapsulation of different monoterpenes in a poloxamer shell in order to prepare aqueous formulations that can be used for the development of platforms used in pest control.MethodsMicellar systems containing a 5 wt% of poloxamer 407 and 1.25 wt% of the different monoterpenes were prepared. Dynamic Light Scattering (DLS) experiments were carried out to characterize the dispersion of the EOCs in water. The pediculicidal activity of these micellar systems was tested on head lice using anex vivoimmersion test.ResultsThe poloxamers allowed the dispersion of EOCs in water due to their encapsulation inside the hydrophobic core of the copolymer micelles. From this study, we concluded that it is possible to make stable micellar systems containing water (>90 wt%), 1.25 wt% of different monoterpenes and a highly safe polymer (5wt% Poloxamer 407). These formulations were effective against head lice with mortality ranging from 30 to 60%, being the most effective emulsions those containing linalool, 1,8-cineole,α-terpineol, thymol, eugenol, geraniol and nonyl alcohol which lead to mortalities above 50%.DiscussionSince these systems showed good pediculicidal activity and high physicochemical stability, they could be a new route for the green fabrication of biocompatible and biosustainable insecticide formulations.

scholarly journals HPLC Determination of Chlorophenols in Water with Separation by Ionic Liquids [Bmim]BF4 Aqueous Two-phase Solvent Sublation

2013 ◽  
Vol 25 (4) ◽  
pp. 2129-2134 ◽  
Author(s):  
Liang Wang ◽  
Hong Zhu ◽  
Chunhong Ma ◽  
Yongsheng Yan
Keyword(s):  
Ionic Liquids ◽  
Hplc Determination ◽  
Two Phase
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