Non-natural Amino Acids Containing Peptide-Capped Gold Nanoparticles for Drug Delivery Application

2013 ◽  
Vol 5 (14) ◽  
pp. 6484-6493 ◽  
Author(s):  
Shaheena Parween ◽  
Ashraf Ali ◽  
Virander S. Chauhan
Keyword(s):  
Drug Delivery ◽  
Amino Acids ◽  
Gold Nanoparticles ◽  
Drug Delivery Application ◽  
Natural Amino Acids

scholarly journals Micelles Based on Lysine, Histidine, or Arginine: Designing Structures for Enhanced Drug Delivery

2021 ◽  
Vol 9 ◽  
Author(s):  
Li Xie ◽  
Rong Liu ◽  
Xin Chen ◽  
Mei He ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acids ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Building Blocks ◽  
Drug Carriers ◽  
Basic Amino Acids ◽  
Key Points ◽  
The Common ◽  
Natural Amino Acids

Natural amino acids and their derivatives are excellent building blocks of polymers for various biomedical applications owing to the non-toxicity, biocompatibility, and ease of multifunctionalization. In the present review, we summarized the common approaches to designing and constructing functional polymeric micelles based on basic amino acids including lysine, histidine, and arginine and highlighted their applications as drug carriers for cancer therapy. Different polypeptide architectures including linear polypeptides and dendrimers were developed for efficient drug loading and delivery. Besides, polylysine- and polyhistidine-based micelles could enable pH-responsive drug release, and polyarginine can realize enhanced membrane penetration and gas therapy by generating metabolites of nitric oxide (NO). It is worth mentioning that according to the structural or functional characteristics of basic amino acids and their derivatives, key points for designing functional micelles with excellent drug delivery efficiency are importantly elaborated in order to pave the way for exploring micelles based on basic amino acids.

Synthesis and characteristics of ethylenediamine-N,N'-di-S-α-isovalerate and isomers of its cobalt(III) complexes

1982 ◽  
Vol 47 (1) ◽  
pp. 210-216 ◽  
Author(s):  
Milan Strašák ◽  
František Bachratý ◽  
Jaroslav Majer
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
Electronic Absorption ◽  
Electronic Absorption Spectra ◽  
Chemical Parameters ◽  
Methyl Group ◽  
Nmr Data ◽  
Physico Chemical ◽  
Natural Amino Acids ◽  
C Nmr

The synthesis and physico-chemical parameters are described of a new complexone based on natural amino acids, viz. ethylenediamine-N,N'-di-S-α-isovalerate (SS-EDDIV). 1H- and 13C-NMR data revealed that the methyl group in the substance are not equivalent. The isomers of the cobalt(III) complex with the asymmetric tetradentate SS-EDDIV ligand were prepared and separated; their characteristics are given. The absolute configuration of two of the five theoretically feasible isomers was determined based on their electronic absorption spectra and circular dichroism data.

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