A significant role of permeability on blood flow for hybrid nanofluid through bifurcated stenosed artery: Drug delivery application

2020 ◽  
Vol 187 ◽  
pp. 105248 ◽  
Author(s):  
Iqra Shahzadi ◽  
S. Bilal
Keyword(s):  
Drug Delivery ◽  
Blood Flow ◽  
Significant Role ◽  
Hybrid Nanofluid ◽  
Drug Delivery Application ◽  
Stenosed Artery

scholarly journals Significant role of cationic polymers in drug delivery systems

2017 ◽  
pp. 1-20 ◽  
Author(s):  
Masoud Farshbaf ◽  
Soodabeh Davaran ◽  
Amir Zarebkohan ◽  
Nasim Annabi ◽  
Abolfazl Akbarzadeh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Significant Role ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cationic Polymers

scholarly journals Unsteady hybrid nanoparticle-mediated magneto-hemodynamics and heat transfer through an overlapped stenotic artery: Biomedical drug delivery simulation

2021 ◽  
pp. 095441192110260
Author(s):  
Jayati Tripathi ◽  
Buddakkagari Vasu ◽  
Osman Anwar Bég ◽  
Rama Subba Reddy Gorla
Keyword(s):  
Drug Delivery ◽  
Blood Flow ◽  
Stokes Equations ◽  
Volume Fraction ◽  
Hybrid Nanoparticles ◽  
Navier Stokes ◽  
Hybrid Nanofluid ◽  
Two Dimensional ◽  
Governing Equations ◽  
Navier Stokes Equations

Two-dimensional laminar hemodynamics through a diseased artery featuring an overlapped stenosis was simulated theoretically and computationally. This study presented a mathematical model for the unsteady blood flow with hybrid biocompatible nanoparticles (Silver and Gold) inspired by drug delivery applications. A modified Tiwari-Das volume fraction model was adopted for nanoscale effects. Motivated by the magneto-hemodynamics effects, a uniform magnetic field was applied in the radial direction to the blood flow. For realistic blood behavior, Reynolds’ viscosity model was applied in the formulation to represent the temperature dependency of blood. Fourier’s heat conduction law was assumed and heat generation effects were included. Therefore, the governing equations were an extension of the Navier–Stokes equations with magneto-hydrodynamic body force included. The two-dimensional governing equations were transformed and normalized with appropriate variables, and the mild stenotic approximation was implemented. The strongly nonlinear nature of the resulting dimensionless boundary value problem required a robust numerical method, and therefore the FTCS algorithm was deployed. Validation of solutions for the particular case of constant viscosity and non-magnetic blood flow was included. Using clinically realistic hemodynamic data, comprehensive solutions were presented for silver, and silver-gold hybrid mediated blood flow. A comparison between silver and hybrid nanofluid was also included, emphasizing the use of hybrid nanoparticles for minimizing the hemodynamics. Enhancement in magnetic parameter decelerated the axial blood flow in stenotic region. Colored streamline plots for blood, silver nano-doped blood, and hybrid nano-doped blood were also presented. The simulations were relevant to the diffusion of nano-drugs in magnetic targeted treatment of stenosed arterial diseases.

Non-Newtonian Models for Blood Flow Through an Arterial Stenosis

2011 ◽  
Author(s):  
F. Kh. Tazyukov ◽  
H. A. Khalaf ◽  
Jafar M. Hassan
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Arterial Stenosis ◽  
Stenosed Artery ◽  
Two Dimensional Flow ◽  
Flow Through ◽  
Wall Shear ◽  
Volume Method

The problems of non-Newtonian blood flow through a stenosed artery are solved numerically using Finite Volume Method where the non-Newtonian rheology of the flowing blood is characterised by the Generalised Power-law, Carreau-Yasuda and Cross models. In view of the haemodynamical mechanisms related to atherosclerosis formation and the role of the wall shear stress in initiating and further developing of the disease, the investigation is focused on the two-dimensional flow field and in particular on the distribution of the wall shear stress in the vicinity of the stenosis. A comparison is made between the effects of each rheological model on the aforementioned parameters for different Re number.

scholarly journals MHD hybrid nanofluid flow comprising the medication through a blood artery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wajdi Alghamdi ◽  
Abdelaziz Alsubie ◽  
Poom Kumam ◽  
Anwar Saeed ◽  
Taza Gul
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Blood Flow ◽  
Differential Equations ◽  
Nonlinear Differential Equations ◽  
Circulatory System ◽  
Rectangular Domain ◽  
Hybrid Nanofluid ◽  
Carrier Fluid ◽  
The Magnetic Field

AbstractThe current study focuses on the laminar flow of copper and copper oxide ($${\text{Cu/blood}}$$ Cu/blood and $${\text{Cu}} + {\text{CuO/blood}}$$ Cu + CuO/blood ) hybrid nanoliquid, considering blood as a carrier fluid in a rectangular domain between two permeable channels. This study may manipulate for the purpose such as the drug delivery process, flow dynamic mechanism of the micro-circulatory system. In the proposed model, MHD and heat source/sink on the flow pattern have been studied. Furthermore, the sides of each channel are permeable, allowing the nanoliquid to escape, filter, squeezing and dilating with a fixed velocity. Appropriate transformations are incorporated to convert the governing partial differential equations and the boundary conditions suitable for computation. The elegant homotopy analysis method (HAM) is used to obtain analytic approximations for the resulting system of nonlinear differential equations. The features of flow characteristics such as velocity, and temperature profiles in response to the variations of the emerging parameters are simulated and examined with a physical explanation. The magnetic field plays a vital role in the blood flow and therefore the existing literature has been extending with the addition of magnetic field. Among the many outputs of the study, it is found that the pressure distribution decline with the accumulated values of the magnetic parameter at the center of the flow regime. The augmentation in the temperature distribution estimates the pH values and electric conductivity. Therefore, the $${\text{Cu}}\,\,{\text{and}}\,\,{\text{CuO}}$$ Cu and CuO hybrid nanofluids are used in this study for medication purposes. The magnetic field has an important role in the blood flow and therefore the extending study has been extending using the magnetic field. The heat emission/absorption term is added to the energy equation to maintain the homogeneous temperature for the blood flow. We expect that this work will provide efficient outputs for medical purposes such as drug delivery.

scholarly journals Blood Flow Mediated Hybrid Nanoparticles in Human Arterial System: Recent Research, Development and Applications

2021 ◽  
Vol 10 (1) ◽  
pp. 1-30
Author(s):  
Jayati Tripathi ◽  
B. Vasu ◽  
Rama Subba Reddy Gorla ◽  
Ali J. Chamkha ◽  
P. V. S. N. Murthy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Flow ◽  
Human Body ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Arterial System ◽  
Hybrid Nanoparticles ◽  
Hybrid Nanofluid ◽  
Computational Simulations ◽  
Nano Drug Delivery

Blood flow dynamics contributes an elemental part in the formation and expansion of cardiovascular diseases in human body. Computational simulation of blood flow in the human arterial system has been widely used in recent decades for better understanding the symptomatic spectrum of various diseases, in order to improve already existing or develop new therapeutic techniques. The characteristics of the blood flow in an artery can be changed significantly by arterial diseases, such as aneurysms and stenoses. The progress of atherosclerosis or stenosis in a blood vessel is quite common which may be caused due to the addition of lipids in the arterial wall. Nanofluid is a colloidal mixture of nanometer sized (which ranges from 10–100 m) metallic and non-metallic particles in conventional fluid (such as water, oil). The delivery of nanoparticles is an interesting and growing field in the development of diagnostics and remedies for blood flow complications. An enhancement of nano-drug delivery performance in biological systems, nanoparticles properties such as size, shape and surface characteristics can be regulated. Nanoparticle offers remarkably advantages over the traditional drug delivery in terms of high specificity, high stability, high drug carrying capacity, ability for controlled release. Highly dependency has been found for their behavior under blood flow while checking for their ability to target and penetrate tissues from the blood. In the field of nano-medicine, organic (including polymeric micelles and vesicles, liposomes) and inorganic (gold and mesoporous silica, copper) nanoparticles have been broadly studied as particular carriers because as drug delivery systems they delivered a surprising achievement as a result of their biocompatibility with tissue and cells, their subcellular size, decreased toxicity and sustained release properties. For the extension of nanofluids research, the researchers have also tried to use hybrid nanofluid recently, which is synthesized by suspending dissimilar nanoparticles either in mixture or composite form. The main idea behind using the hybrid nanofluid is to further improve the heat transfer and pressure drop characteristics. Nanoparticles are helpful as drug carriers to minimize the effects of resistance impedance to blood flow or coagulation factors due to stenosis. Discussed various robust approaches have been employed for the nanoparticle transport through blood in arterial system. The main objective of the paper is to provide a comprehensive review of computational simulations of blood flow containing hybrid-nanoparticles as drug carriers in the arterial system of the human body. The recent developments and analysis of convective flow of particle-fluid suspension models for the axi-symmetric arterial bodies in hemodynamics are summarized. Detailed existing mathematical models for simulating blood flow with nanoparticles in stenotic regions are reviewed. The review focuses on selected numerical simulations of physiological convective flows under various stenosis approximations and computation of the temperature, velocity, resistance impedance to flow, wall shear stress and the pressure gradient with the corresponding boundary conditions. The current review also highlights that the drug carrier nanoparticles are efficient mechanisms for reducing hemodynamics of stenosis and could be helpful for other biomedical applications. The review considers flows through various stenoses and the significances of numerical fluid mechanics in clinical medicine. The review examines nano-drug delivery systems, nanoparticles and describes recent computational simulations of nano-pharmacodynamics.

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