scholarly journals Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation

ACS Omega ◽  
2021 ◽  
Author(s):  
Piao Wang ◽  
Yi Liu ◽  
Tong Zhang ◽  
Cheng Yin ◽  
Seok Yong Kang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Myoblast Differentiation ◽  
C2c12 Myoblast ◽  
Root Extract ◽  
High Fat ◽  
Streptozotocin Induced Diabetes

scholarly journals Inula Japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed A High-Fat Diet

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 17 ◽  
Author(s):  
So-Hyun Park ◽  
Da-Hye Lee ◽  
Min Jung Kim ◽  
Jiyun Ahn ◽  
Young-Jin Jang ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Flowering Plant ◽  
Myoblast Differentiation ◽  
C2c12 Myoblast ◽  
Endurance Capacity ◽  
Protein Kinase Activity ◽  
Mrna Levels ◽  
High Fat

Inula japonica Thunb. (Asteraceae) is a flowering plant that grows mainly in Korea, Japan, and China and its flower extract has diverse biological effects such as anti-inflammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study aims to reveal the effects of I. japonica flower ethanol extract (IJE) on obesity and endurance capacity in high-fat diet (HFD) fed C57BL/6J mice and the mechanism. IJE inhibited lipid accumulation in 3T3-L1 adipocytes in vitro. Also, IJE-fed mice showed reduced body weight gain, hepatic lipid, and body fat mass, and increased muscle weight. IJE reduced lipid accumulation in the liver and adipose tissue by decreasing lipogenic and adipogenic gene expression. Additionally, consumption of low-dose IJE significantly enhanced endurance capacity via increasing AMP-activated protein kinase activity and mRNA levels of Myh7 and Myh2. Luteolin and 1β-hydroxyalantolactone (1β-HA), compounds of IJE, are involved in anti-adipogenesis in the 3T3-L cells and only luteolin increased the protein levels of MHC during C2C12 myoblast differentiation. Collectively, our results suggest that consumption of IJE not only helps to prevent obesity but also enhances endurance capacity reduced by HFD.

Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes

2018 ◽  
Vol 234 (5) ◽  
pp. 7510-7523 ◽  
Author(s):  
Dengqiu Xu ◽  
Zhenzhou Jiang ◽  
Zeren Sun ◽  
Lu Wang ◽  
Guolin Zhao ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
High Fat Diet ◽  
Myoblast Differentiation ◽  
High Fat

scholarly journals PROTECTIVE EFFECT OF ETHANOLIC ROOT EXTRACT OF COMMIPHORA CAUDATA AGAINST DIABETIC-INDUCED RATS IN HIGH-FAT DIET-STREPTOZOTOCIN MODEL

2019 ◽  
pp. 563-566
Author(s):  
ANITHA K ◽  
SABAPATHI MOHANA LAKSHMI ◽  
SATYANARAYANA SV
Keyword(s):  
High Fat Diet ◽  
Histopathological Examination ◽  
Screening Method ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
High Density Lipoproteins ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
High Fat ◽  
Standard Drug

Objective: The present study was to explore the phytochemical analysis and antidiabetic potential of the root of Commiphora caudata in high-fat diet (HFD) streptozotocin-induced diabetic rats. Methods: The ethanolic root extract of C. caudata at a dose of 400 mg/kg and 200 mg/kg was administered to diabetic rats. Glibenclamide (5 mg/kg) was used as standard drug. Results: The data were statistically assessed using one-way ANOVA followed by Dennett’s multiple comparison tests. To unfold the mechanism, we studied all the biochemical parameters glucose, total cholesterol, triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very LDL (VLDL) and histopathological examination of the pancreatic tissue section. The ethanolic extracts of root of C. caudata showed significant reduce of the level of cholesterol, TG, LDL, VLDL, and significant increase in the serum level of HDL at 400 mg/kg rather than 200 mg/kg. Conclusion: Further studies should look into the characterization and isolation of the constituents to know the exact mechanism of hypoglycemic activity. Statistical analyses of this screening method confirm that the proposed method is appropriate and it can be expected to improve basic idea to the researcher who is working in area-like antidiabetic activity.

scholarly journals Combined therapy with metformin and insulin attenuates systemic and hepatic alterations in a model of high-fat diet-/streptozotocin-induced diabetes

2016 ◽  
Vol 97 (3) ◽  
pp. 266-277 ◽  
Author(s):  
Raquel Rangel Silvares ◽  
Evelyn Nunes Goulart da Silva Pereira ◽  
Edgar Eduardo Ilaquita Flores ◽  
Vanessa Estato ◽  
Patrícia Alves Reis ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Combined Therapy ◽  
High Fat ◽  
Streptozotocin Induced Diabetes

scholarly journals Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1567 ◽  
Author(s):  
Seunghae Kim ◽  
Mak-Soon Lee ◽  
Sunyoon Jung ◽  
Hye-Yeon Son ◽  
Seonyoung Park ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Root Extract ◽  
Mrna Levels ◽  
Ampk Activation ◽  
High Fat ◽  
Ginger Extract

Ginger is a plant whose rhizome is used as a spice or folk medicine. We aimed to investigate the effect of ginger root extract on obesity and inflammation in rats fed a high-fat diet. Sprague-Dawley rats were divided into three groups and fed either a 45% high-fat diet (HF), HF + hot-water extract of ginger (WEG; 8 g/kg diet), or HF + high-hydrostatic pressure extract of ginger (HPG; 8 g/kg diet) for 10 weeks. The HPG group had lower body weight and white adipose tissue (WAT) mass compared to the HF group. Serum and hepatic lipid levels of HPG group were lower, while fecal lipid excretion of the HPG group was higher than that of the HF group. In the WAT of the WEG and HPG groups, mRNA levels of adipogenic genes were lower than those of the HF group. Moreover, HPG group had lower mRNA levels of pro-inflammatory cytokines than did the HF group. MicroRNA (miR)-21 expression was down-regulated by both WEG and HPG. Additionally, miR-132 expression was down-regulated by HPG. The adenosine monophosphate-activated protein kinase (AMPK) activity of HPG group was greater than that of the HF group. HPG may have beneficial effects on obesity and inflammation, partially mediated by regulation of miR-21/132 expression and AMPK activation in WAT.

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