scholarly journals Combined therapy with metformin and insulin attenuates systemic and hepatic alterations in a model of high-fat diet-/streptozotocin-induced diabetes

2016 ◽  
Vol 97 (3) ◽  
pp. 266-277 ◽  
Author(s):  
Raquel Rangel Silvares ◽  
Evelyn Nunes Goulart da Silva Pereira ◽  
Edgar Eduardo Ilaquita Flores ◽  
Vanessa Estato ◽  
Patrícia Alves Reis ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Combined Therapy ◽  
High Fat ◽  
Streptozotocin Induced Diabetes

scholarly journals Antioxidant and Ameliorative Potential of Aqueous Seed extracts of Delonix regia on High Fat Diet and Streptozotocin Induced Diabetes in Female Wistar Rats

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
BLESSING MINAOPUNYE ONYEGEME‐OKERENTA ◽  
PHILIP OSEIKHUENMHEN OGBOYE ◽  
COMFORT CHINAZO MONAGO‐IGHORODJE ◽  
IFEOMA NWAMAKA MONAGO
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat ◽  
Delonix Regia ◽  
Female Wistar Rats ◽  
Streptozotocin Induced Diabetes ◽  
Seed Extracts

scholarly journals Streptozotocin-Induced Diabetes Partially Attenuates the Effects of a High-Fat Diet on Liver and Brain Fatty Acid Composition in Mice

Lipids ◽  
2013 ◽  
Vol 48 (9) ◽  
pp. 939-948 ◽  
Author(s):  
Beth Levant ◽  
Marlies K. Ozias ◽  
Brianne L. Guilford ◽  
Douglas E. Wright
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
High Fat Diet ◽  
High Fat ◽  
Streptozotocin Induced Diabetes

scholarly journals The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy

2009 ◽  
Vol 2009 ◽  
pp. 1-9 ◽  
Author(s):  
Eric Davidson ◽  
Lawrence Coppey ◽  
Bao Lu ◽  
Victor Arballo ◽  
Nigel A. Calcutt ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
High Fat Diet ◽  
Neutral Endopeptidase ◽  
Diabetic Animal ◽  
Glucose Disposal ◽  
Neural Function ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Neuroactive Peptides ◽  
Streptozotocin Induced Diabetes

We demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuroactive peptides, improves vascular and neural function in diabetic animal models. In this study we explored the role of NEP in neuropathy related to either insulin-deficient diabetes or diet-induced obesity using NEP deficient (−/−) mice. Initial studies showed that streptozotocin, in the absence of subsequent hyperglycemia, did not induce nerve conduction slowing or paw thermal hypoalgesia. Glucose disposal was impaired in both C57Bl/6 and NEP −/− mice fed a high fat diet. Thermal hypoalgesia and nerve conduction slowing were present in both streptozotocin-diabetic and high fat fed C57Bl/6 mice but not in NEP −/− mice exposed to either streptozotocin-induced diabetes or a high fat diet. These studies suggest that streptozotocin does not induce neurotoxicity in mice and that NEP plays a role in regulating nerve function in insulin-deficient diabetes and diet-induced obesity.

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