scholarly journals Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment

ACS Nano ◽  
2019 ◽  
Vol 13 (5) ◽  
pp. 5451-5464 ◽  
Author(s):  
Patricia Mora-Raimundo ◽  
Daniel Lozano ◽  
Miguel Manzano ◽  
María Vallet-Regí
Keyword(s):  
Osteoporosis Treatment ◽  
Related Gene ◽  
Osteogenic Marker ◽  
Marker Expression

scholarly journals Zinc Ameliorates the Osteogenic Effects of High Glucose in Vascular Smooth Muscle Cells

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3083
Author(s):  
Laura A. Henze ◽  
Misael Estepa ◽  
Burkert Pieske ◽  
Florian Lang ◽  
Kai-Uwe Eckardt ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Calcification ◽  
Vascular Smooth Muscle Cells ◽  
High Glucose ◽  
Muscle Cells ◽  
Zinc Treatment ◽  
Osteogenic Marker ◽  
Marker Expression

In diabetic patients, medial vascular calcification is common and associated with increased cardiovascular mortality. Excessive glucose concentrations can activate the nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-kB) and trigger pro-calcific effects in vascular smooth muscle cells (VSMCs), which may actively augment vascular calcification. Zinc is able to mitigate phosphate-induced VSMC calcification. Reduced serum zinc levels have been reported in diabetes mellitus. Therefore, in this study the effects of zinc supplementation were investigated in primary human aortic VSMCs exposed to excessive glucose concentrations. Zinc treatment was found to abrogate the stimulating effects of high glucose on VSMC calcification. Furthermore, zinc was found to blunt the increased expression of osteogenic and chondrogenic markers in high glucose-treated VSMCs. High glucose exposure was shown to activate NF-kB in VSMCs, an effect that was blunted by additional zinc treatment. Zinc was further found to increase the expression of TNFα-induced protein 3 (TNFAIP3) in high glucose-treated VSMCs. The silencing of TNFAIP3 was shown to abolish the protective effects of zinc on high glucose-induced NF-kB-dependent transcriptional activation, osteogenic marker expression, and the calcification of VSMCs. Silencing of the zinc-sensing receptor G protein-coupled receptor 39 (GPR39) was shown to abolish zinc-induced TNFAIP3 expression and the effects of zinc on high glucose-induced osteogenic marker expression. These observations indicate that zinc may be a protective factor during vascular calcification in hyperglycemic conditions.

scholarly journals New insight into the role of a combination of zinc oxide and turmeric rhizome liquid extract in osteogenic marker expression

2021 ◽  
Vol 21 (3) ◽  
pp. 262
Author(s):  
Astari Puteri ◽  
Jennifer Widjaja ◽  
Indeswati Diyatri ◽  
Wibi Riawan ◽  
Asti Meizarini
Keyword(s):  
Zinc Oxide ◽  
Osteogenic Marker ◽  
Liquid Extract ◽  
Marker Expression ◽  
Insight Into

Khat affects apoptosis and related gene XIAP and Smac expression following transient focal ischemia in rats

2010 ◽  
Vol 34 (8) ◽  
pp. S16-S16
Author(s):  
Fang‑fang Bi ◽  
Hadi M. Mujlli ◽  
Yue‑qiang Hu ◽  
Fa‑fa Tian ◽  
Zhi‑guo Wu ◽  
...  
Keyword(s):  
Focal Ischemia ◽  
Related Gene ◽  
Transient Focal Ischemia
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