scholarly journals Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone-grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans

2017 ◽  
Vol 8 (3) ◽  
pp. 31 ◽  
Author(s):  
Christine Knabe ◽  
Doaa Adel Khattab ◽  
Esther Kluk ◽  
Rainer Struck ◽  
Michael Stiller
Keyword(s):  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Bone Grafting ◽  
Volume Stability ◽  
Osteogenic Marker ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
Marker Expression

scholarly journals Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone Grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans

2017 ◽  
Author(s):  
Christine Knabe ◽  
Doaa Adel-Khattab ◽  
Esther Kluk ◽  
Rainer Struck ◽  
Michael Stiller
Keyword(s):  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Area Fraction ◽  
Bone Area ◽  
Volume Stability ◽  
Osteogenic Marker ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
Particle Area ◽  
Graft Volume

This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. Biopsies were processed for immunohistochemical analysis of resin embedded sections. Sections were stained for collagen type I (Col I), alkaline phosphatase (ALP), osteocalcin (OC) and bone sialoprotein (BSP). Furthermore, the bone area and particle area fraction were determined histomorphometrically. Cone-beam CT data recorded after SFA and 6 month later were used for calculating the graft volume at these two time points. TCP-P displayed more advantageous surgical handling properties and a significantly greater bone area fraction and smaller particle area fraction. This was accompanied by significantly greater expression of Col I and BSP and in osteoblasts and osteoid and a less pronounced reduction in grafting volume with TCP-P. SFA using both types of materials resulted in formation of sufficient bone volume for facilitating stable dental implant placement with all dental implants having been in function without any complications for 6 years. Since TCP-P displayed superior surgical handling properties and greater bone formation than TCP-G, without the Hyac hydrogel matrix having any adverse effect on bone formation or graft volume stability, TCP-P can be regarded as excellent grafting material for SFA in a clinical setting.

scholarly journals EFFECT OF A BIOACTIVE CALCIUM ALKALI ORTHOPHOSPHATE BONE GRAFTING MATERIAL AS COMPARED TO TRICALCIUM PHOSPHATE ON OSTEOGENESIS AFTER SINUS FLOOR AUGMENTATION IN PATIENTS

2021 ◽  
Vol 57 (1) ◽  
pp. 1-18
Author(s):  
Hana- Ayad Ensir ◽  
◽  
Tom Knauf ◽  
Doaa Adel-Khattab ◽  
Alina Bednarek ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Bone Grafting ◽  
Type I ◽  
Complete Replacement ◽  
Volume Stability ◽  
Posterior Maxilla ◽  
Sinus Floor Augmentation ◽  
Sinus Floor

Sinus floor augmentation (SFA) has become a well-recognized procedure for site development in the atrophic posterior maxilla prior to dental implant placement. There has been an increasing search for relatively rapidly resorbable bone substitutes that enhance bone formation and facilitate bone regeneration with complete replacement by functional bone tissue. This has led to the development of a glassy crystalline silica-containing calcium alkali orthophosphate (Si-CAOP). The specific aim of this study was to assess histologically the effect of this grafting material on osteogenesis and osteogenic marker expression and to compare this effect to that of β-tricalcium phosphate (β-TCP) in human biopsies obtained 6 months after SFA. Cylindrical biopsies, harvested 6 months after SFA, were processed for immunohistochemical analysis of sawed hard tissue sections using primary antibodies specific to osteocalcin (OC), collagen type I (Col I), bone sialoprotein (BSP), and alkaline phosphatase (ALP). Furthermore, the bone and particle area fraction were measured histomorphometrically in all biopsies in order to characterize bone formation and degradation of the bone grafting materials. Both biomaterials facilitated osteoblast differentiation and bone regeneration of resorbed alveolar ridges, resulting in sufficient bone formation for supporting dental implants. Si-CAOP specimens displayed more advanced bone formation and significantly greater particle degradation than TCP sites. This was accompanied by significantly higher expression of OC, Col I, BSP, and ALP in the osteoid in contact with the degrading particles. These promising results indicate that the Si-CAOP material has great potential use for SFA in humans, thereby confirming its superiority to β-TCP. A prospective study involving a larger patient number, a split-mouth design and analysis of angiogenic properties and of cone-beam CT-data for assessing the volume stability of the augmented area is warranted to further confirm the high osteogenic capacity of Si-CAOP for orofacial bone regeneration.

Performance of β-tricalcium phosphate granules and putty, bone grafting materials after bilateral sinus floor augmentation in humans

Biomaterials ◽  
2014 ◽  
Vol 35 (10) ◽  
pp. 3154-3163 ◽  
Author(s):  
Michael Stiller ◽  
Esther Kluk ◽  
Marc Bohner ◽  
Marco A. Lopez-Heredia ◽  
Christian Müller-Mai ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Grafting ◽  
Bone Grafting Materials ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
Grafting Materials

Effect of β-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humans

Biomaterials ◽  
2008 ◽  
Vol 29 (14) ◽  
pp. 2249-2258 ◽  
Author(s):  
Christine Knabe ◽  
Christian Koch ◽  
Alexander Rack ◽  
Michael Stiller
Keyword(s):  
Tricalcium Phosphate ◽  
Sinus Floor Augmentation ◽  
Sinus Floor

Histomorphometry of human sinus floor augmentation using a porous beta-tricalcium phosphate: a prospective study

2004 ◽  
Vol 15 (6) ◽  
pp. 724-732 ◽  
Author(s):  
Ilara R. Zerbo ◽  
Steven A. Zijderveld ◽  
Anje de Boer ◽  
Antonius L. J. J. Bronckers ◽  
Gert de Lange ◽  
...  
Keyword(s):  
Prospective Study ◽  
Tricalcium Phosphate ◽  
Beta Tricalcium Phosphate ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
A Prospective Study
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