Khat affects apoptosis and related gene XIAP and Smac expression following transient focal ischemia in rats

2010 ◽  
Vol 34 (8) ◽  
pp. S16-S16
Author(s):  
Fang‑fang Bi ◽  
Hadi M. Mujlli ◽  
Yue‑qiang Hu ◽  
Fa‑fa Tian ◽  
Zhi‑guo Wu ◽  
...  
Keyword(s):  
Focal Ischemia ◽  
Related Gene ◽  
Transient Focal Ischemia

Aggravation of brain injury after transient focal ischemia in p53-deficient mice

2001 ◽  
Vol 88 (1-2) ◽  
pp. 54-61 ◽  
Author(s):  
Keiichiro Maeda ◽  
Ryuji Hata ◽  
Frank Gillardon ◽  
Konstantin-Alexander Hossmann
Keyword(s):  
Brain Injury ◽  
Focal Ischemia ◽  
Transient Focal Ischemia ◽  
Deficient Mice

scholarly journals Protective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage

2010 ◽  
Vol 31 (4) ◽  
pp. 1107-1118 ◽  
Author(s):  
Slavianka G Moyanova ◽  
Federica Mastroiacovo ◽  
Lidia V Kortenska ◽  
Rumiana G Mitreva ◽  
Erminia Fardone ◽  
...  
Keyword(s):  
Brain Damage ◽  
Metabotropic Glutamate Receptors ◽  
Infarct Volume ◽  
Focal Ischemia ◽  
Protective Role ◽  
Ischemic Brain Damage ◽  
Systemic Injection ◽  
Ischemic Brain ◽  
Metabotropic Glutamate ◽  
Transient Focal Ischemia

We examined the influence of type 4 metabotropic glutamate (mGlu4) receptors on ischemic brain damage using the permanent middle cerebral artery occlusion (MCAO) model in mice and the endothelin-1 (Et-1) model of transient focal ischemia in rats. Mice lacking mGlu4 receptors showed a 25% to 30% increase in infarct volume after MCAO as compared with wild-type littermates. In normal mice, systemic injection of the selective mGlu4 receptor enhancer, N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-caboxamide (PHCCC; 10 mg/kg, subcutaneous, administered once 30 minutes before MCAO), reduced the extent of ischemic brain damage by 35% to 45%. The drug was inactive in mGlu4 receptor knockout mice. In the Et-1 model, PHCCC administered only once 20 minutes after ischemia reduced the infarct volume to a larger extent in the caudate/putamen than in the cerebral cortex. Ischemic rats treated with PHCCC showed a faster recovery of neuronal function, as shown by electrocorticographic recording and by a battery of specific tests, which assess sensorimotor deficits. These data indicate that activation of mGlu4 receptors limit the development of brain damage after permanent or transient focal ischemia. These findings are promising because selective mGlu4 receptor enhancers are under clinical development for the treatment of Parkinson's disease and other central nervous system disorders.

Prevention of neuronal damage by calcium channel blockers with antioxidative effects after transient focal ischemia in rats

2007 ◽  
Vol 1176 ◽  
pp. 143-150 ◽  
Author(s):  
Violeta Lukic-Panin ◽  
Tatsushi Kamiya ◽  
HanZhe Zhang ◽  
Takeshi Hayashi ◽  
Atsushi Tsuchiya ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Neuronal Damage ◽  
Focal Ischemia ◽  
Channel Blockers ◽  
Antioxidative Effects ◽  
Transient Focal Ischemia

Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

2003 ◽  
Vol 976 (1) ◽  
pp. 120-124 ◽  
Author(s):  
Chun Shu Piao ◽  
Young-Mi Yu ◽  
Pyung-Lim Han ◽  
Ja-Kyeong Lee
Keyword(s):  
Focal Ischemia ◽  
Dynamic Expression ◽  
Transient Focal Ischemia
Sign in / Sign up

Export Citation Format

Share Document