Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles

ACS Nano ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 386-398 ◽  
Author(s):  
Yali Jia ◽  
Xiaobing Wang ◽  
Dehong Hu ◽  
Pan Wang ◽  
Quanhong Liu ◽  
...  
Keyword(s):  
Active Targeting ◽  
Orthotopic Glioma

scholarly journals Correction to Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Yali Jia ◽  
Xiaobing Wang ◽  
Dehong Hu ◽  
Pan Wang ◽  
Quanhong Liu ◽  
...  
Keyword(s):  
Active Targeting ◽  
Orthotopic Glioma

scholarly journals Active Targeting of Orthotopic Glioma Using Biomimetic Liposomes Co-loaded Elemene and Cabazitaxel Modified By Transferritin

2021 ◽  
Author(s):  
JIE LI ◽  
Huamin Zeng ◽  
Yu You ◽  
Rongrong Wang ◽  
Tiantian Tan ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Tumor Location ◽  
Active Targeting ◽  
Intake Rate ◽  
Tumor Penetration ◽  
Cell Membrane Proteins ◽  
The Brain ◽  
Orthotopic Glioma

Abstract Efficient chemotherapy for glioma demands a nanocarrier that can overcome the blood-brain barrier (BBB) and then target the tumor location. Elemene (ELE) and cabazitaxel (CTX) liposomes are prepared by conjugating liposomes with transferrin (Tf) and embedding the cell membrane proteins of RG2 glioma into liposomes (active-targeting biomimetic liposomes, Tf-ELE/CTX@BLIP), which are demonstrated resultful in infiltrating the BBB and targeting glioma, respectively. Tf-ELE/CTX@BLIP is highly stable, displaying a prominent peculiarity of homologous targeting and of immune evasion in vitro, and a 5.83-fold intake rate when versus classical liposome (ELE/CTX@LIP). The result of bioluminescence imaging revealed enhanced drugs accumulation in the brain and increased tumor penetration of Tf-ELE/CTX@BLIP in orthotopic glioma model nude mice. In vivo studies demonstrated that the anti-tumor effect of the Tf-ELE/CTX@BLIP include increased survival time and decreased tumor volume. Following intravenous administration of Tf-ELE/CTX@BLIP, the tumor averaged fluorescence intensity was 65.2, 12.5, 22.1, 6.6, 2.6, 1.5 times weaker than that of the control, CTX solution, ELE solution, ELE/CTX@LIP, ELE/CTX@BLIP, Tf-ELE/CTX@LIP groups, respectively. Moreover, histopathological analyses demonstrated that Tf-ELE/CTX@BLIP were less toxic than the CTX solution. These results suggest that the active-targeting biomimetic liposomes, Tf-ELE/CTX@BLIP, is a promising nanoplatform for glioma chemotherapy.

scholarly journals Active targeting of orthotopic glioma using biomimetic liposomes co-loaded elemene and cabazitaxel modified by transferritin

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jie Li ◽  
Huamin Zeng ◽  
Yu You ◽  
Rongrong Wang ◽  
Tiantian Tan ◽  
...  
Keyword(s):  
In Vivo Studies ◽  
Active Targeting ◽  
Histopathological Analysis ◽  
Intake Rate ◽  
Tumor Lesion ◽  
Cell Membrane Proteins ◽  
The Brain ◽  
Orthotopic Glioma

Abstract Background Effective treatment of glioma requires a nanocarrier that can cross the blood–brain barrier (BBB) to target the tumor lesion. In the current study, elemene (ELE) and cabazitaxel (CTX) liposomes were prepared by conjugating liposomes with transferrin (Tf) and embedding the cell membrane proteins of RG2 glioma cells into liposomes (active-targeting biomimetic liposomes, Tf-ELE/CTX@BLIP), which exhibited effective BBB infiltration to target glioma. Results The findings showed that Tf-ELE/CTX@BLIP was highly stable. The liposomes exhibited highly significant homologous targeting and immune evasion in vitro and a 5.83-fold intake rate compared with classical liposome (ELE/CTX@LIP). Bioluminescence imaging showed increased drug accumulation in the brain and increased tumor penetration of Tf-ELE/CTX@BLIP in orthotopic glioma model nude mice. Findings from in vivo studies indicated that the antitumor effect of the Tf-ELE/CTX@BLIP led to increased survival time and decreased tumor volume in mice. The average tumor fluorescence intensity after intravenous administration of Tf-ELE/CTX@BLIP was 65.2, 12.5, 22.1, 6.6, 2.6, 1.5 times less compared with that of the control, CTX solution, ELE solution, ELE/CTX@LIP, ELE/CTX@BLIP, Tf-ELE/CTX@LIP groups, respectively. Histopathological analysis showed that Tf-ELE/CTX@BLIP were less toxic compared with administration of the CTX solution. Conclusion These findings indicate that the active-targeting biomimetic liposome, Tf-ELE/CTX@BLIP, is a promising nanoplatform for delivery of drugs to gliomas. Graphic Abstract

Transferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy

2017 ◽  
Vol 23 (3) ◽  
pp. 454-466 ◽  
Author(s):  
Daniele R. Nogueira-Librelotto ◽  
Cristiane F. Codevilla ◽  
Ammad Farooqi ◽  
Clarice M. B. Rolim
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Therapeutic Benefit ◽  
Active Targeting ◽  
Future Research ◽  
Passive Targeting ◽  
The Right ◽  
Review Current ◽  
Target Effects

A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic performances in different tumor models as compared to their passive targeting counterparts. In this review, current development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate the progression on the strategies for cancer therapy in view of the future research.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

scholarly journals Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

2021 ◽  
Vol 6 (12) ◽  
pp. 4402-4414
Author(s):  
Yueyue Fan ◽  
Yuexin Cui ◽  
Wenyan Hao ◽  
Mengyu Chen ◽  
Qianqian Liu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Active Targeting ◽  
Carrier Free

scholarly journals Comparison Direct Synthesis of Hyaluronic Acid-Based Carbon Nanodots as Dual Active Targeting and Imaging of HeLa Cancer Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Yu-Yu Aung ◽  
Aswandi Wibrianto ◽  
Jefry S. Sianturi ◽  
Desita K. Ulfa ◽  
Satya. C. W. Sakti ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Direct Synthesis ◽  
Active Targeting ◽  
Carbon Nanodots

Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density

Biomaterials ◽  
2014 ◽  
Vol 35 (27) ◽  
pp. 8015-8027 ◽  
Author(s):  
Zhaomin Tang ◽  
Dan Li ◽  
Huili Sun ◽  
Xing Guo ◽  
Yuping Chen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Active Targeting ◽  
Ligand Density

Multifunctional mesoporous silica nanocarriers for stimuli-responsive target delivery of anticancer drugs

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 92073-92091 ◽  
Author(s):  
Yujuan Chen ◽  
Hui Zhang ◽  
Xiaoqing Cai ◽  
Jianbo Ji ◽  
Shuwang He ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Functional Groups ◽  
Anticancer Drugs ◽  
Outer Surface ◽  
Active Targeting ◽  
Stimuli Responsive ◽  
Target Delivery

By modifying the outer surface of MSNs with various functional groups or/and using a combination with other nanomaterials, stimuli-responsive and active targeting nanosystems can be designed for stimuli-responsive target delivery of anticancer drugs.

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