Cancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy

ACS Nano ◽  
2017 ◽  
Vol 11 (7) ◽  
pp. 7006-7018 ◽  
Author(s):  
Shi-Ying Li ◽  
Hong Cheng ◽  
Bo-Ru Xie ◽  
Wen-Xiu Qiu ◽  
Jing-Yue Zeng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Cancer Cell

Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy

Biomaterials ◽  
2017 ◽  
Vol 142 ◽  
pp. 149-161 ◽  
Author(s):  
Shi-Ying Li ◽  
Hong Cheng ◽  
Wen-Xiu Qiu ◽  
Lu Zhang ◽  
Shuang-Shuang Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Targeted Photodynamic Therapy

scholarly journals A NIR-I light-responsive superoxide radical generator with cancer cell membrane targeting ability for enhanced imaging-guided photodynamic therapy

2020 ◽  
Vol 11 (37) ◽  
pp. 10279-10286 ◽  
Author(s):  
Yingcui Bu ◽  
Tianren Xu ◽  
Xiaojiao Zhu ◽  
Jie Zhang ◽  
Lianke Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Cell Viability ◽  
Cancer Cell ◽  
Superoxide Radical ◽  
Self Report ◽  
Membrane Targeting ◽  
Targeting Ability ◽  
Enhanced Imaging

A NIR-I light initiated theranostic system based on photosensitizer EBD-1 with cancer cell membrane targeting ability, which can self-report cell viability.

Cancer cell membrane-coated magnetic nanoparticles for MR/NIR fluorescence dual-modal imaging and photodynamic therapy

2018 ◽  
Vol 6 (7) ◽  
pp. 1834-1845 ◽  
Author(s):  
Jiong Li ◽  
Xuandong Wang ◽  
Dongye Zheng ◽  
Xinyi Lin ◽  
Zuwu Wei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Nanoparticles ◽  
Cell Membrane ◽  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Nir Fluorescence

A photosensitizer-loaded magnetic nanobead with surface coated with a cancer cell membrane to enhance MR/NIR fluorescence imaging and PDT efficacy.

Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

2020 ◽  
Vol 20 ◽  
Author(s):  
Vasil Tsanov ◽  
Hristo Tsanov
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Quantum Chemical ◽  
Density Functional ◽  
Enzyme Regulation ◽  
Amide Derivatives ◽  
Pass Through ◽  
Hydrolysis Of ◽  
Derivatives Of

Background:: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semi-empirical methods, is considered. Objective:: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and / or modified forms to counteract "external" bioactive activity. Cancers, for their part, have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops according to its instructions. Methods:: Derived pedestal that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent density-functional quantum- chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to forms causing chemical apoptosis of the cell - independent of its non-genetic set, which seeks to counteract the process. Results:: Used in oncology it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). Conclusion:: The amide derivatives of nitrile glycosides exhibit anti-cancer activity, the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide- carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and / or permanently damage its normal physiology.

scholarly journals Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

2021 ◽  
Vol 6 (12) ◽  
pp. 4402-4414
Author(s):  
Yueyue Fan ◽  
Yuexin Cui ◽  
Wenyan Hao ◽  
Mengyu Chen ◽  
Qianqian Liu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Active Targeting ◽  
Carrier Free

scholarly journals Investigation of an Optical Imaging Platform Integrated with an Ultrasound Application System for In Vitro Verification of Ultrasound-Mediated Drug Delivery

2021 ◽  
Vol 11 (6) ◽  
pp. 2846
Author(s):  
Jong-ryul Choi ◽  
Juyoung Park
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Cell Membrane ◽  
Optical Imaging ◽  
Cancer Cell ◽  
Fluorescent Imaging ◽  
Calcium Flux ◽  
Cervical Cancer Cell ◽  
Application System ◽  
Ultrasound Application

Techniques that increase the permeability of the cell membrane and transfer drugs or genes to cells have been actively developed as effective therapeutic modalities. Also, in line with the development of these drug delivery techniques, the establishment of tools to verify the techniques at the cellular level is strongly required. In this study, we demonstrated an optical imaging platform integrated with an ultrasound application system to verify the feasibility of safe and efficient drug delivery through the cell membrane using ultrasound-microbubble cavitation. To examine the potential of the platform, fluorescence images of both Fura-2 AM and propidium iodide (PI) to measure calcium flux changes and intracellular PI delivery, respectively, during and after the ultrasound-microbubble cavitation in the cervical cancer cell were acquired. Using the optical imaging platform, we determined that calcium flux increased immediately after the ultrasound-microbubble cavitation and were restored to normal levels, and fluorescence signals from intracellular PI increased gradually after the cavitation. The results acquired by the platform indicated that ultrasound-microbubble cavitation can deliver PI into the cervical cancer cell without irreversible damage of the cell membrane. The application of an additional fluorescent imaging module and high-speed imaging modalities can provide further improvement of the performance of this platform. Also, as additional studies in ultrasound instrumentations to measure real-time cavitation signals progress, we believe that the ultrasound-microbubble cavitation-based sonoporation can be employed for safe and efficient drug and gene delivery to various cancer cells.

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