scholarly journals Elucidation of the Structure and Synthesis of Neuroprotective Low Molecular Mass Components of the Parawixia bistriata Spider Venom

2020 ◽  
Vol 11 (11) ◽  
pp. 1573-1596
Author(s):  
Yvonne M. Forster ◽  
Jennifer Leigh Green ◽  
Apeksha Khatiwada ◽  
José Luiz Liberato ◽  
Poli Adi Narayana Reddy ◽  
...  
Keyword(s):  
Molecular Mass ◽  
Spider Venom ◽  
Parawixia Bistriata

scholarly journals Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats

2013 ◽  
Vol 543 ◽  
pp. 12-16 ◽  
Author(s):  
Erica A. Gelfuso ◽  
José L. Liberato ◽  
Alexandra O.S. Cunha ◽  
Márcia R. Mortari ◽  
Renê O. Beleboni ◽  
...  
Keyword(s):  
Spider Venom ◽  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Chemical Kindling ◽  
Gaba Uptake Inhibitor ◽  
Parawixia Bistriata

Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine

2006 ◽  
Vol 69 (6) ◽  
pp. 1998-2006 ◽  
Author(s):  
Renê Oliveira Beleboni ◽  
Renato Guizzo ◽  
Andréia Cristina Karklin Fontana ◽  
Andrea Baldocchi Pizzo ◽  
Ruither Oliveira Gomes Carolino ◽  
...  
Keyword(s):  
Spider Venom ◽  
Parawixia Bistriata

scholarly journals Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae)

2011 ◽  
Vol 22 (2) ◽  
pp. 158-164 ◽  
Author(s):  
Helene Aparecida Fachim ◽  
Alexandra Olimpio Siqueira Cunha ◽  
Adriana Colsera Pereira ◽  
René Oliveira Beleboni ◽  
Leonardo Gobbo-Neto ◽  
...  
Keyword(s):  
Spider Venom ◽  
Parawixia Bistriata

scholarly journals VenoMS—A Website for the Low Molecular Mass Compounds in Spider Venoms

Metabolites ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 327
Author(s):  
Yvonne M. Forster ◽  
Silvan Reusser ◽  
Florian Forster ◽  
Stefan Bienz ◽  
Laurent Bigler
Keyword(s):  
Mass Spectrometry ◽  
Molecular Mass ◽  
High Performance ◽  
Structural Information ◽  
Spider Venom ◽  
Electrospray Tandem Mass Spectrometry ◽  
Resource Saving ◽  
Fragment Ions ◽  
Polyamine Derivatives ◽  
Potential Use

Spider venoms are highly complex mixtures. Numerous spider venom metabolites are uniquely found in spider venoms and are of interest concerning their potential use in pharmacology, agriculture, and cosmetics. A nontargeted ultra-high performance high-resolution electrospray tandem mass spectrometry (UHPLC-HR-ESI-MS/MS) approach offers a resource-saving way for the analysis of crude spider venom. However, the identification of known as well as the structure elucidation of unknown low molecular mass spider venom compounds based on their MS/MS spectra is challenging because (1) acylpolyamine toxins are exclusively found in spider and wasp venom, (2) reference MS/MS spectra are missing in established mass spectrometry databases, and (3) trivial names for the various toxin metabolites are used in an inconsistent way in literature. Therefore, we introduce the freely accessible MS website for low molecular mass spider venom metabolites, venoMS, containing structural information, MS/MS spectra, and links to related literature. Currently the database contains the structures of 409 acylpolyamine toxins, 36 free linear polyamines, and 81 additional spider venom metabolites. Implemented into this website is a fragment ion calculator (FRIOC) that allows us to predict fragment ions of linear polyamine derivatives. With three metabolites from the venom of the spider Agelenopsis aperta, it was demonstrated how the new website can support the structural elucidation of acylpolyamines using their MS/MS spectra.

Acid and alkaline phosphatase activities of a fraction isolated from Parawixia bistriata spider venom

Toxicon ◽  
2006 ◽  
Vol 47 (8) ◽  
pp. 854-858 ◽  
Author(s):  
Marcelo Cairrão Araujo Rodrigues ◽  
Luis Henrique Souza Guimarães ◽  
José Luis Liberato ◽  
Maria de Lourdes Teixeira de Moraes Polizeli ◽  
Wagner Ferreira dos Santos
Keyword(s):  
Alkaline Phosphatase ◽  
Spider Venom ◽  
Phosphatase Activities ◽  
Acid And Alkaline Phosphatase ◽  
Parawixia Bistriata

scholarly journals Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake

2003 ◽  
Vol 139 (7) ◽  
pp. 1297-1309 ◽  
Author(s):  
Andréia Cristina Karklin Fontana ◽  
Renato Guizzo ◽  
Renê de Oliveira Beleboni ◽  
Antonio Renato Meirelles e Silva ◽  
Norberto Cysne Coimbra ◽  
...  
Keyword(s):  
Glutamate Uptake ◽  
Spider Venom ◽  
Parawixia Bistriata
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