034 — (LIB0083) Parawixin10: A new natural compound from Parawixia bistriata spider venom that presents neuroprotective, memory-saving, and disease-modifying effects in the pilocarpine model of TLE in Wistar rats

2014 ◽  
Vol 38 ◽  
pp. 196
Author(s):  
J.L. Liberato ◽  
L.D. Godoy ◽  
M.R. Mortari ◽  
L. Gobbo-Neto ◽  
N.P. Lopes ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Natural Compound ◽  
Spider Venom ◽  
Pilocarpine Model ◽  
Disease Modifying ◽  
Parawixia Bistriata

Neuroethological analysis of the effects of spider venom from Scaptocosa raptoria (Lycosidae: Araneae) microinjected in the lateral ventricle of Wistar rats

2000 ◽  
Vol 52 (6) ◽  
pp. 581-588 ◽  
Author(s):  
Alessandra Mussi Ribeiro ◽  
Wagner Ferreira dos Santos ◽  
Norberto Garcia-Cairasco
Keyword(s):  
Lateral Ventricle ◽  
Wistar Rats ◽  
Spider Venom

scholarly journals Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats

2013 ◽  
Vol 543 ◽  
pp. 12-16 ◽  
Author(s):  
Erica A. Gelfuso ◽  
José L. Liberato ◽  
Alexandra O.S. Cunha ◽  
Márcia R. Mortari ◽  
Renê O. Beleboni ◽  
...  
Keyword(s):  
Spider Venom ◽  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Chemical Kindling ◽  
Gaba Uptake Inhibitor ◽  
Parawixia Bistriata

Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats

Life Sciences ◽  
2007 ◽  
Vol 80 (6) ◽  
pp. 566-572 ◽  
Author(s):  
Erica Aparecida Gelfuso ◽  
Alexandra Olimpio Siqueira Cunha ◽  
Marcia Renata Mortari ◽  
Jose Luiz Liberato ◽  
Karina Haddad Paraventi ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Social Spider ◽  
The Social ◽  
Parawixia Bistriata

scholarly journals Effect of aerobic physical exercise in pinealectomized animals submitted to the pilocarpine model of epilepsy

2006 ◽  
Vol 12 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Marcelo Reina Siliano ◽  
Eliângela Lima ◽  
Sandra Gomes Valente ◽  
Maria da Graça Naffah-Mazzacoratti ◽  
Esper Abrão Cavalheiro ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Neuronal Death ◽  
Wistar Rats ◽  
Mossy Fiber ◽  
Exercise Program ◽  
Chronic Exercise ◽  
Program Material ◽  
Positive Effects ◽  
Pilocarpine Model ◽  
Physical Program

OBJECTIVE: To better clarify the positive effects of physical exercise in the epilepsy, we analyzed the effect of the pinealectomy in animals with temporal lobe epilepsy (TLE) induced by pilocarpine submitted to an aerobic physical program. MATERIAL AND METHODS: Forty adults Wistar rats were used: 1) PX + CHRONIC - Pinealectomized animals (PX) with TLE (CHRONIC) without exercise (n = 9); 2) PX + CHRONIC + EXERCISE - submitted to an aerobic physical exercise program (n = 5); 3) CHRONIC - without exercise (n = 8); 4) CHRONIC + EXERCISE (n = 8); 5) CTRL - control without exercise (n = 5); 6) CTRL + EXERCISE (n = 5). The physical exercise program consisted of 1 hour of treadmill, 5 days/week, during 30 days, at 60% VO2max. The Nissl and neo-Timm methods were used. RESULTS: The pinealectomy increased the frequency of seizures in animals with epilepsy. It was observed a reduction of the neuronal death and mossy fiber sprouting in the animals with epilepsy submitted to an aerobic physical exercise program. However, the physical exercise program did not modify the frequency of the seizures in the pinealectomized animals.

Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine

2006 ◽  
Vol 69 (6) ◽  
pp. 1998-2006 ◽  
Author(s):  
Renê Oliveira Beleboni ◽  
Renato Guizzo ◽  
Andréia Cristina Karklin Fontana ◽  
Andrea Baldocchi Pizzo ◽  
Ruither Oliveira Gomes Carolino ◽  
...  
Keyword(s):  
Spider Venom ◽  
Parawixia Bistriata

scholarly journals Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae)

2011 ◽  
Vol 22 (2) ◽  
pp. 158-164 ◽  
Author(s):  
Helene Aparecida Fachim ◽  
Alexandra Olimpio Siqueira Cunha ◽  
Adriana Colsera Pereira ◽  
René Oliveira Beleboni ◽  
Leonardo Gobbo-Neto ◽  
...  
Keyword(s):  
Spider Venom ◽  
Parawixia Bistriata

Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy

2011 ◽  
Vol 61 (1-2) ◽  
pp. 313-328 ◽  
Author(s):  
Jennifer François ◽  
Katuschia Germe ◽  
Arielle Ferrandon ◽  
Estelle Koning ◽  
Astrid Nehlig
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pilocarpine Model ◽  
Disease Modifying

Acid and alkaline phosphatase activities of a fraction isolated from Parawixia bistriata spider venom

Toxicon ◽  
2006 ◽  
Vol 47 (8) ◽  
pp. 854-858 ◽  
Author(s):  
Marcelo Cairrão Araujo Rodrigues ◽  
Luis Henrique Souza Guimarães ◽  
José Luis Liberato ◽  
Maria de Lourdes Teixeira de Moraes Polizeli ◽  
Wagner Ferreira dos Santos
Keyword(s):  
Alkaline Phosphatase ◽  
Spider Venom ◽  
Phosphatase Activities ◽  
Acid And Alkaline Phosphatase ◽  
Parawixia Bistriata
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